Bio‐Inspired Mineral Growth on Porous Spherulitic Textured Poly(L‐lactic acid)/Bioactive Glass Composite Scaffolds

Ghosh, Satyabrata; Reis, Rui L.; Mano, João F.

doi:10.1002/adem.200700360

Cited by 8 publications

(7 citation statements)

References 32 publications

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“…21 Generally, the classical biomimetic coating using SBF on various substrates (e.g., metal implants) takes about 1-4 weeks for the bone-like apatite coating. 22 However, in the present study, we report the results obtained after 48 h. XRD (using CoKa as a target) studies of nanocomposites synthesized in the present study confirmed the formation of HA coexisting with OCP particles on the surface of the PVA hydrogel. All the three samples revealed almost identical diffraction patterns (Fig.…”

Section: Resultssupporting

confidence: 45%

“…An irreversible hydrolysis of OCP, leading to a transition product that comprises of OCP and HA has been regarded as an appropriate prototype for an apatitic mineral, 20 which is also confirmed by the similarity of the crystalline structure of the two minerals 21 . Generally, the classical biomimetic coating using SBF on various substrates (e.g., metal implants) takes about 1–4 weeks for the bone‐like apatite coating 22 . However, in the present study, we report the results obtained after 48 h.…”

Section: Resultsmentioning

confidence: 88%

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Surface Mineralization of Hydrogels Through Octacalcium Phosphate

Guha

Sinha

2010

International Journal of Applied Ceramic Technology

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Simulated body fluid‐induced nucleation and growth of octacalcium phosphate (OCP) on polyvinyl alcohol–hydroxyapatite (HA) hydrogels has been described and discussed in the present manuscript. Bulk mineralization of hydrogels is well reported in the literature for structural tissue engineering applications. However, a good interfacing between hydrogel scaffolds and biological organ, such as bone, could only be achieved through a suitable surface chemistry modification of the scaffold. OCP, a precursor to biological HA, may be an appropriate component of the hydrogel's surface likely to be used as a scaffold for bone tissue engineering.

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Section: Resultssupporting

confidence: 45%

Section: Resultsmentioning

confidence: 88%

Surface Mineralization of Hydrogels Through Octacalcium Phosphate

Guha

Sinha

2010

International Journal of Applied Ceramic Technology

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“…[1] Calcium phosphate-based ceramic materials have been the most promising bone substitute as their chemical and crystal structures are remarkably similar to natural bone. [2] However, their limited bone regeneration capacity and poor biomechanical behavior hinder their clinical applications. More importantly, the porous structure of the scaffolds governs their mechanical properties as well as new bone ingrowth.…”

Section: Introductionmentioning

confidence: 99%

3D‐Plotted Beta‐Tricalcium Phosphate Scaffolds with Smaller Pore Sizes Improve In Vivo Bone Regeneration and Biomechanical Properties in a Critical‐Sized Calvarial Defect Rat Model

Diao

Ouyang

Deng

et al. 2018

Adv Healthcare Materials

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Due to the difficulty in fabricating bioceramic scaffolds with smaller pore sizes by the current 3D printing technique, the effect of smaller pore sizes (below 400 µm) of 3D printed bioceramic scaffolds on the bone regeneration and biomechanical behavior is never studied. Herein beta-tricalcium phosphate (β-TCP) scaffolds with interconnected smaller pores of three different sizes (100, 250, and 400 µm) are fabricated by 3D plotting. The resultant scaffolds are then implanted into rat critical-sized calvarial defects without any seeded cells. A custom-designed device is developed to investigate the biomechanical properties of the scaffolds after surgical implantation for 4, 8, and 12 weeks. The scaffolds with the 100 µm pore size are found to present the highest maximum load and stiffness, comparable to those of the autogenous bone, after being implanted for 12 weeks. Micro-computed tomography (micro-CT) and histological analysis further indicate that the scaffolds with the 100 µm pore size achieve the highest percentage of new bone ingrowth, which correlates to their best in vivo biomechanical properties. This study demonstrates that tailoring the pore size of β-TCP scaffolds to a smaller range by 3D-plotting can be a facile and efficient approach to enhanced bone regeneration and biomechanical behaviors in bone repair.

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“…The combination of salt and another polymeric water soluble porogen, such as poly(ethylene oxide), PEO, permits the formation of pores with a textured surface due to the fingerprint left by PEO spherulites that are leached out during the scaffold processing [52] -see Figure 6 (B) -left. It was found that when Bioglass® is present in such textured scaffolds the ceramic formed upon immersion in SBF has a completely different nature that could lead to a different biological performance of the implant -see Figure 6 (B) -right [53]. This result demonstrates the relevance of surface topography in the morphology of the calcium phosphate coating that is developed during immersion in SBF.…”

Section: Biomimetic Calcium Phosphate Coatings In the Biomedical Areamentioning

confidence: 50%

Mineralized structures in nature: Examples and inspirations for the design of new composite materials and biomaterials

Luz

Mano

2010

Composites Science and Technology

138

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Through the natural evolutionary process, organisms have been improving amazing mineralized materials for a series of functions using a relatively few constituent elements. Biomineralization has been widely studied in the last years. It is important to understand how minerals are produced by organisms and also their structure and the corresponding relationship with the properties and function. Moreover, one can look at minerals as a tool that could be used to develop high performance materials, through design inspiration and to find novel processing routes functioning at mild conditions of temperature, pressure and solvent type. As important as the molecular constituents are structural factors, which include the existence of different levels of organization and controlled orientation. Moreover, the way how the hierarchical levels are linked and interfacial features plays also a major role in the final behavior of the biogenic composite. The main aim of this work is to review the latest contributions that have been reported on composite materials produced in nature, and to relate their structures at different length scales to their main functions and properties. There is also an interest in developing new biomimetic procedures that could induce the production of calcium phosphate coatings, similar to bone apatite in substrates for biomedical applications, namely in orthopedic implants and scaffolds for tissue engineering and regenerative medicine; this topic will be also addressed. Finally, we also review the latest proposed approaches to develop novel synthetic materials and coatings inspired from natural-based nanocomposites.Keywords: Biomimetics, biocomposites, structure-property relationships, biomaterials, mineralization.ACCEPTED MANUSCRIPT 2 1. Introduction Nature, through the evolutionary process, has been able to design and produce highly sophisticated materials, used for a variety of functions, including for structural purposes [1], [2]. The physical properties of biological systems, such as the mechanical performance, are typically far better than that of the equivalent synthetic materials, with similar compositions and processed with present technologies. Moreover, these materials are produced at mild temperature and pressure conditions, with relatively low energy consumption. Finally, such systems are made with significant weak components such as brittle minerals, soft proteins and water. Therefore, nature has been a fascinating source of inspiration for scientists and engineers. Biomimetics is an emerging field of science that includes the study of how Nature designs, processes and assembles/disassembles molecular building blocks to fabricate high performance hard polymer-based composites (e.g., mollusc shells, bone, tooth) and/or soft materials (e.g., skin, cartilage, tendons), and then applies these designs and processes to engineer new molecules and materials with unique properties [3], [4], [5]. Biologically inspired design or adaptation or derivation from nature is referred to as 'biomim...

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Bio‐Inspired Mineral Growth on Porous Spherulitic Textured Poly(L‐lactic acid)/Bioactive Glass Composite Scaffolds

Cited by 8 publications

References 32 publications

Surface Mineralization of Hydrogels Through Octacalcium Phosphate

Surface Mineralization of Hydrogels Through Octacalcium Phosphate

3D‐Plotted Beta‐Tricalcium Phosphate Scaffolds with Smaller Pore Sizes Improve In Vivo Bone Regeneration and Biomechanical Properties in a Critical‐Sized Calvarial Defect Rat Model

Mineralized structures in nature: Examples and inspirations for the design of new composite materials and biomaterials

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