Bio-macromolecules/modified-halloysite composite hydrogel used as multi-functional wound dressing

Xu, Zhangpeng; Gao, Yingjun; Li, Jingjing; Dai, Jingjing; Zhu, Shanshan; Meng, Kai; Yin, Weiyao; Zhao, Haipeng

doi:10.1016/j.smaim.2021.03.004

Cited by 11 publications

(5 citation statements)

References 45 publications

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“…Clinically, skin wound infection may exhibit varied severity ranging from superficial paronychia to life-threatening bone infection ( 38 – 45 ). Moreover, skin wounds also face high risk of repeated damage and reinfection resulting from external mechanical irritation.…”

Section: Resultsmentioning

confidence: 99%

Reversible dougong structured receptor–ligand recognition for building dynamic extracellular matrix mimics

Bai

et al. 2022

Proc. Natl. Acad. Sci. U.S.A.

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Dynamic biomaterials excel at recapitulating the reversible interlocking and remoldable structure of the extracellular matrix (ECM), particularly in manipulating cell behaviors and adapting to tissue morphogenesis. While strategies based on dynamic chemistries have been extensively studied for ECM-mimicking dynamic biomaterials, biocompatible molecular means with biogenicity are still rare. Here, we report a nature-derived strategy for fabrication of dynamic biointerface as well as a three-dimensional (3D) hydrogel structure based on reversible receptor–ligand interaction between the glycopeptide antibiotic vancomycin and dipeptide d-Ala-d-Ala. We demonstrate the reversible regulation of multiple cell types with the dynamic biointerface and successfully implement the dynamic hydrogel as a functional antibacterial 3D scaffold to treat tissue repair. In view of the biogenicity and high applicability, this nature-derived reversible molecular strategy will bring opportunities for malleable biomaterial design with great potential in biomedicine.

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Section: Resultsmentioning

confidence: 99%

Reversible dougong structured receptor–ligand recognition for building dynamic extracellular matrix mimics

Bai

et al. 2022

Proc. Natl. Acad. Sci. U.S.A.

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“…Skin is the first barrier against exogenous microorganisms. [ 51 ] It is of great significance to maintain the integrity of the skin and promote wound healing. [ 52 ] Previous evidence suggests that the level of tissue oxygenation may be an essential rate‐limiting factor in the wound healing response.…”

Section: Hemoglobin‐related Biomaterials For Wound Healing and Antiba...mentioning

confidence: 99%

Hemoglobin‐Related Biomaterials and their Applications

Sun

Ouyang

et al. 2022

Advanced NanoBiomed Research

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Hemoglobin (Hb) is a physiological oxygen‐transport metalloprotein present in the red blood cells. With the in‐depth study, many functions of Hb are developed, and kinds of Hb‐related biomaterials are applied for biomedical therapeutics in the past decades. Herein, the recent advances of Hb‐related biomaterials and their applications, including the clinical progress of Hb‐based oxygen carriers (HBOCs) as blood substitutes, and the applications in the field of tumor therapy, wound healing, and anti‐inflammation therapy through utilizing its function of multiple gas delivery (O2, CO, NO), peroxidase‐like catalysis, and targeting macrophage, are summarized. With the rapid development of science and technology, more versatile Hb‐related biomaterials are designed in the future for other applications.

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“…To accelerate tissue regeneration, various strategies have been designed, including hydrogels, , scaffolds, – films, , microspheres, , and cell therapy. – These strategies can mimic the extracellular matrix structure at wound sites to guide cell migration and reorganization, consequently accelerating the regeneration of tissue. Among these strategies, hydrogels have been widely used.…”

Section: Introductionmentioning

confidence: 99%

Electroactive Hydrogels with Photothermal/Photodynamic Effects for Effective Wound Healing Assisted by Polydopamine-Modified Graphene Oxide

Xie,

Luo,

Luo

et al. 2023

ACS Appl. Mater. Interfaces

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Bio-macromolecules/modified-halloysite composite hydrogel used as multi-functional wound dressing

Cited by 11 publications

References 45 publications

Reversible dougong structured receptor–ligand recognition for building dynamic extracellular matrix mimics

Reversible dougong structured receptor–ligand recognition for building dynamic extracellular matrix mimics

Hemoglobin‐Related Biomaterials and their Applications

Electroactive Hydrogels with Photothermal/Photodynamic Effects for Effective Wound Healing Assisted by Polydopamine-Modified Graphene Oxide

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