Bioabsorbable engineered nanobiomaterials for antibacterial therapy

Yadav, Ramdayal; Kandasubramanian, Balasubramanian

doi:10.1016/b978-0-323-41532-3.00003-8

Cited by 14 publications

(7 citation statements)

References 179 publications

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“…Nanomaterials with two dimensions and polymers have been used and investigated for their antimicrobial utility [ 96 , 97 ]. Among them, MXene materials have demonstrated more antibacterial action than graphene oxide (GO), a well-studied antimicrobial agent, and Ti 3 C 2 has demonstrated considerably stronger antibacterial activity against both E. coli and B. subtilis [ 3 ].…”

Section: Biomedical Applications Of Mxenesmentioning

confidence: 99%

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MXene (Ti3C2Tx)-Embedded Nanocomposite Hydrogels for Biomedical Applications: A Review

et al. 2022

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Polymeric nanocomposites have been outstanding functional materials and have garnered immense attention as sustainable materials to address multi-disciplinary problems. MXenes have emerged as a newer class of 2D materials that produce metallic conductivity upon interaction with hydrophilic species, and their delamination affords monolayer nanoplatelets of a thickness of about one nm and a side size in the micrometer range. Delaminated MXene has a high aspect ratio, making it an alluring nanofiller for multifunctional polymer nanocomposites. Herein, we have classified and discussed the structure, properties and application of major polysaccharide-based electroactive hydrogels (hyaluronic acid (HA), alginate sodium (SA), chitosan (CS) and cellulose) in biomedical applications, starting with the brief historical account of MXene’s development followed by successive discussions on the synthesis methods, structures and properties of nanocomposites encompassing polysaccharides and MXenes, including their biomedical applications, cytotoxicity and biocompatibility aspects. Finally, the MXenes and their utility in the biomedical arena is deliberated with an eye on potential opportunities and challenges anticipated for them in the future, thus promoting their multifaceted applications.

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Section: Biomedical Applications Of Mxenesmentioning

confidence: 99%

“…( D ) Ti 3 C 2 T x MXene and Ti 3 AlC 2 MAX XRD patterns. ( E ) Water contact angles ( n = 3) on Ti 3 C 2 T x MXene films [ 96 ].…”

Section: Figurementioning

confidence: 99%

MXene (Ti3C2Tx)-Embedded Nanocomposite Hydrogels for Biomedical Applications: A Review

et al. 2022

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“…In recent years, electrospun nanofiber scaffolds have been demonstrated to be effective nano-scale therapeutic devices, as their physicochemical properties can be tailored to several applications requiring necessary antimicrobial capabilities [ 27 , 28 , 29 ]. In particular, nanofibrous structures have several intrinsic properties which make them peculiarly functional to design for antimicrobial applications [ 19 , 30 , 31 , 32 , 33 , 34 ]. Ideally, fiber diameters at the nanometric scale make their structure suitable to bio-mimic the natural extracellular matrix (ECM) of tissue, thus providing a friendly environment for the regeneration of the target site and facilitating repair mechanisms [ 33 , 34 , 35 ].…”

Section: Polymeric Nanofibers and Electrospun Scaffoldsmentioning

confidence: 99%

“…Excessive ROS production will cause severe oxidative stress that will damage the bacterial cellular components, disrupt protein synthesis, inhibit enzymatic action, and cause cell membrane disruption and site-specific DNA damage, ultimately leading to cell lysis [ 176 , 177 , 178 ]. In recent years, metal nanoparticles such as silver and gold, as well as metal oxide nanoparticles such as zinc oxide, iron oxide, titanium dioxide, and copper oxide have been extensively studied for antimicrobial applications [ 31 , 157 , 176 , 179 , 180 , 181 ]. Although the bactericidal ability of these metal and metal oxide nanoparticles is well documented, the precise mechanism of action is still unknown.…”

Section: Entrapment Of Antimicrobial Agents Into Nanofibers: Classificationmentioning

confidence: 99%

Functionalized Antimicrobial Nanofibers: Design Criteria and Recent Advances

Hamdan

Yamin

Hamid

et al. 2021

JFB

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The rise of antibiotic resistance has become a major threat to human health and it is spreading globally. It can cause common infectious diseases to be difficult to treat and leads to higher medical costs and increased mortality. Hence, multifunctional polymeric nanofibers with distinctive structures and unique physiochemical properties have emerged as a neo-tool to target biofilm and overcome deadly bacterial infections. This review emphasizes electrospun nanofibers’ design criteria and properties that can be utilized to enhance their therapeutic activity for antimicrobial therapy. Also, we present recent progress in designing the surface functionalization of antimicrobial nanofibers with non-antibiotic agents for effective antibacterial therapy. Lastly, we discuss the future trends and remaining challenges for polymeric nanofibers.

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“…Among all the mentioned materials, natural polymers − were the ones that gained popularity since they have the ability to mimic the natural ECM . Chitosan, − polylactic acid, collagen, and gelatin are some of the typically investigated natural polymers, but they had certain drawbacks such as complicated processing, quick degradation, and low mechanical strength, which developed other natural polymers in tissue engineering, for example, silk proteins …”

Section: Introductionmentioning

confidence: 99%

Silk-Based Composite Scaffolds for Tissue Engineering Applications

Tandon

Kandasubramanian

Ibrahim

2020

Ind. Eng. Chem. Res.

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Tissue engineering is an interdisciplinary field that aims toward the repair of the tissues and organs by bringing together the chemists, material scientists, and biologists to work in coordination for a better understanding of cell−polymer interactions. The leading challenge in the field of tissue engineering is to mimic the naturally occurring extracellular matrix due to which scaffold engineering has become the central area of research in this field. Various materials have been investigated for the fabrication of scaffolds; silk-based composites are among the most promising materials because of their secure processing, adequate mechanical strength, biodegradability, biocompatibility, hemocompatibility, and oxygen and water permeability. This review extensively focuses on the silk-based composite scaffolds, their fabrication, sterilization, and applications in tissue engineering.

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Bioabsorbable engineered nanobiomaterials for antibacterial therapy

Cited by 14 publications

References 179 publications

MXene (Ti3C2Tx)-Embedded Nanocomposite Hydrogels for Biomedical Applications: A Review

MXene (Ti3C2Tx)-Embedded Nanocomposite Hydrogels for Biomedical Applications: A Review

Functionalized Antimicrobial Nanofibers: Design Criteria and Recent Advances

Silk-Based Composite Scaffolds for Tissue Engineering Applications

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