Bioactive albumin functionalized polylactic acid membranes for improved biocompatibility

Nyanhongo, Gibson S.; Rodríguez, Rafael Moreno; Prasetyo, Endry Nugroho; Caparrós, Cristina; Ribeiro, Clarisse; Sencadas, Vítor; Lanceros‐Méndez, S.; Acero, Enrique Herrero; Guebitz, Georg M.

doi:10.1016/j.reactfunctpolym.2012.12.007

Cited by 32 publications

(27 citation statements)

References 47 publications

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“…1 As a promising biomedical material, poly(lactic acid) (PLA) is biodegradable, bioabsorbable, renewable and extensively investigated. [1][2][3] However, PLA is relatively hydrophobic and lacks reactive sidechain groups 1 when it is used as a human blood-contacting material. Li et al improved the hemocompatibility of polypropylene by attaching silver nanoparticles capped with TPGS.…”

Section: Introductionmentioning

confidence: 99%

Hemocompatible poly(lactic acid) membranes prepared by immobilizing carboxylated graphene oxide via mussel-inspired method for hemodialysis

Huang

Zhang

et al. 2018

RSC Adv.

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Section: Introductionmentioning

confidence: 99%

Hemocompatible poly(lactic acid) membranes prepared by immobilizing carboxylated graphene oxide via mussel-inspired method for hemodialysis

Huang

Zhang

et al. 2018

RSC Adv.

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“…The PLA FTIR spectrum is displayed in Figure . It reveals the main PLA bands at 2996 cm −1 and 2945 cm −1 , attributed to asymmetric stretching vibrations of CH 3 groups; 1748 cm −1 , related to stretching and bending vibrations of CO groups; 1453 cm −1 , attributed to asymmetric deformation vibrations of CH 3 ; 1382 cm −1 and 1359 cm −1 , attributed to symmetric deformation vibrations of CH 3 ; 1303 cm −1 , 1266 cm −1 , and 1206 cm −1 (shoulder), related to deformation vibrations of tertiary carbons; 1180 cm −1 , attributed to C─O stretching vibrations of lactide units or to C─O─C asymmetric stretching; 1127 cm −1 , attributed to C─H (of CH 3 groups) rocking mode; 1081 cm −1 and 1043 cm −1 , where the first one is related to C─O─C asymmetric stretching and the second to C─CH 3 stretching vibration, or both could be due to rocking vibrations of CH 3 ; 956 cm −1 , related to stretching of C─C bonds; 869 cm −1 and 752 cm −1 , attributed to ─CH 2 ─ rocking vibrations; and 705 cm −1 and 668 cm −1 …”

Section: Resultsmentioning

confidence: 99%

Poly(lactic acid) biocomposites with mango waste and organo‐montmorillonite for packaging

Lima

Minguita

et al. 2019

J of Applied Polymer Sci

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Poly(lactic acid) (PLA) is a biodegradable polymer used in packaging, but its properties can be improved by manufacturing composite matrixes. The combination of PLA, starch, and nano‐montmorillonite leads to materials with superior mechanical properties. Mango lump is rich in cellulose and starch. The goal of this study is to develop and characterize biocomposites based on PLA, mango waste, and nano‐organo‐montmorillonite for packaging. The samples were microstructurally, morphologically, and mechanically characterized. Physical interaction between the phases was observed. The mango components displaced the PLA X‐ray diffraction peaks and the clays altered their intensity, by interfering with chain packing. The addition of single components to PLA increased the samples’ transition temperatures, but the addition of multiple components diminished them. PLA showed adhesiveness to cellulose fibers and nonadhesiveness to starch granules. Thicker samples presented better mechanical properties. PLA–mango–“chocolate clay” samples are relatively stable materials, while PLA–mango–“bofe clay” samples could represent promising highly biodegradable materials. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47512.

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“…However, the current chemical modification method is very complex, and also may damage the polymer substrates themselves. Recently, various strategies including decoration of PLA with natural materials like albumin, gelatin, collagen, or alginate have been intensely investigated to improve the biocompatibility of PLA-based biomaterials [ 19 , 20 ]. These methods have been found to improve cell attachment and growth [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, various strategies including decoration of PLA with natural materials like albumin, gelatin, collagen, or alginate have been intensely investigated to improve the biocompatibility of PLA-based biomaterials [ 19 , 20 ]. These methods have been found to improve cell attachment and growth [ 20 , 21 ]. However, the introduction of natural products onto PLA surface may introduce some complex chemical elements onto the interface, which may greatly complicate the process procedure, and also induce some immunogenic responses [ 6 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Development of bioabsorbable polylactide membrane with controllable hydrophilicity for adjustment of cell behaviours

Yang¹,

Qiu

Sun

et al. 2018

R. Soc. open sci.

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Cell functions can be mediated through their interactions with the microenvironments, which highly depend on the surface state of the substrate. However, how to finely adjust the surface of biomaterials is still very challenging. In this study, poly(d,l-lactide) (PDLLA) with high molecular weight was synthesized via ring opening polymerization, which was hot-pressed into PDLLA membrane. In order to modify the hydrophobicity of the membrane (a limiting factor for its biomedical application), an amphiphilic monomethoxyl poly(ethylene glycol)-b-poly(d,l-lactide) (PEG-PDLLA) was selected to improve its surface hydrophilicity through a simple self-assembly approach. It was found that the contact angles of the modified membrane can be well controlled by variation of PEG-PDLLA concentrations. In vitro cell biological study indicates that optimized cell adhesion can be achieved on the modified membrane with a contact angle of around 50° via its self-assembly with an ethanol/water solution of PEG-PDLA (35 mg ml−1). The surface modification of the membrane also changed its biodegradation property in the process of its incubation period up to 240 days. The surface modification method may afford an effective way for adjustment of the surface (interface) of membrane (scaffolds) of different biomaterials, beyond polylactide.

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Bioactive albumin functionalized polylactic acid membranes for improved biocompatibility

Cited by 32 publications

References 47 publications

Hemocompatible poly(lactic acid) membranes prepared by immobilizing carboxylated graphene oxide via mussel-inspired method for hemodialysis

Hemocompatible poly(lactic acid) membranes prepared by immobilizing carboxylated graphene oxide via mussel-inspired method for hemodialysis

Poly(lactic acid) biocomposites with mango waste and organo‐montmorillonite for packaging

Development of bioabsorbable polylactide membrane with controllable hydrophilicity for adjustment of cell behaviours

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