Bioactive antibacterial silica-based nanocomposites hydrogel scaffolds with high angiogenesis for promoting diabetic wound healing and skin repair

Li, Yannan; Xu, Tianzhen; Tu, Zhuolong; Dai, Wentong; Xue, Yumeng; Tang, Chengxuan; Gao, Weiyang; Mao, Cong; Lei, Bo; Lin, Cai

doi:10.7150/thno.41839

Cited by 169 publications

(112 citation statements)

References 41 publications

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“…The in vivo results of the study showed increased number of vessels, high levels of blood flow volume, and accelerated wound healing (Fig. 6) [176].…”

Section: Skin Tissue Engineeringmentioning

confidence: 88%

Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis

et al. 2021

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Skin is the body’s first barrier against external pathogens that maintains the homeostasis of the body. Any serious damage to the skin could have an impact on human health and quality of life. Tissue engineering aims to improve the quality of damaged tissue regeneration. One of the most effective treatments for skin tissue regeneration is to improve angiogenesis during the healing period. Over the last decade, there has been an impressive growth of new potential applications for nanobiomaterials in tissue engineering. Various approaches have been developed to improve the rate and quality of the healing process using angiogenic nanomaterials. In this review, we focused on molecular mechanisms and key factors in angiogenesis, the role of nanobiomaterials in angiogenesis, and scaffold-based tissue engineering approaches for accelerated wound healing based on improved angiogenesis.

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“…The in vivo results of the study showed increased number of vessels, high levels of blood flow volume, and accelerated wound healing (Fig. 6) [176].…”

Section: Skin Tissue Engineeringmentioning

confidence: 88%

Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis

et al. 2021

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“…3 c, d). HIF-1α targets the downstream genes that regulate cell function and angiogenesis under hypoxic conditions [ 29 ], therefore, the low expression of this factor in the EF-Sponge indicated that the EF-Sponge sample provided an oxygen-rich environment for the cells, thus stimulating angiogenesis. As such, it was further affirmed that the porous structure of the scaffolds not only promoted cell proliferation but also facilitated the repair process following endothelial injury.…”

Section: Resultsmentioning

confidence: 99%

Electrospun fibrous sponge via short fiber for mimicking 3D ECM

Wang

Qian

et al. 2021

J Nanobiotechnol

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Background Most of the natural extracellular matrix (ECM) is a three-dimensional (3D) network structure of micro/nanofibers for cell adhesion and growth of 3D. Electrospun fibers distinctive mimicked 2D ECM, however, it is impossible to simulate 3D ECM because of longitudinal collapse of continuous micro/nanofibers. Herein, 3D electrospun micro/nano-fibrous sponge was fabricated via electrospinning, homogenization, shaping and thermal crosslinking for 3D tissue regeneration of cells and vascular. Results Fibrous sponge exhibited high porosity, water absorption and compression resilience and no chemical crosslinked agent was used in preparation process. In vitro studies showed that the 3D short fiber sponge provided an oxygen-rich environment for cell growth, which was conducive to the 3D proliferation and growth of HUVECs, stimulated the expression of VEGF, and well promoted the vascularization of HUVECs. In vivo studies showed that the 3D short fiber sponges had a good 3D adhesion to the chronic wound of diabetes in rats. Furthermore, 3D short fibrous sponges were better than 2D micro/nanofiber membranes in promoting the repair of diabetic full-thickness skin defects including wound healing, hair follicle regeneration, angiogenesis, collagen secretion. Conclusion Therefore, electrospun short fibrous sponges are special candidates for mimicking the 3D ECM and promoting 3D regeneration of tissue. Graphic Abstract

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“…3c-d). HIF-1α targets the downstream genes that regulate cell function and angiogenesis under hypoxic conditions [26], therefore, the high expression of this factor indicated that the EF-Sponge sample provided an oxygen-rich environment for the cells, thus stimulating angiogenesis. As such, it was further a rmed that the porous structure of the scaffolds not only promoted cell proliferation but also facilitated the repair process following endothelial injury.…”

Section: Biocompatibility and Angiogenesis Of Huvecsmentioning

confidence: 99%

Electrospun Fibrous Sponge via Short Fiber for Mimicking 3D ECM

Wang

Qian

et al. 2021

Preprint

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BackgroundMost of the natural extracellular matrix (ECM) is a three-dimensional (3D) network structure of micro/nanofibers for cell adhesion and growth of 3D. Electrospun fibers distinctive mimicked 2D ECM, however, it is impossible to simulate 3D ECM because of longitudinal collapse of continuous micro/nanofibers. Herein, 3D electrospun micro/nanofibrous sponge was fabricated via electrospinning, homogenization, short fiber and thermal crosslinking for 3D tissue regeneration of cells and vascular. ResultsFibrous sponge exhibited high porosity, water absorption and compression resilience and no chemical crosslinked agent was used in preparation process. In vitro studies showed that the 3D short fiber sponge provided an oxygen-rich environment for cell growth, which was conducive to the 3D proliferation and growth of HUVECs, stimulated the expression of VEGF, and well promoted the vascularization of HUVECs. In vivo studies showed that the 3D short fiber sponges had a good 3D adhesion to the chronic wound of diabetes in rats. Furthermore, 3D short fibrous sponges were better than 2D micro/nanofiber membranes in promoting the repair of diabetic full-thickness skin defects including wound healing, hair follicle regeneration, angiogenesis, collagen secretion. ConclusionTherefore, electrospun short fibrous sponges are special candidates for mimicking the 3D ECM and promoting 3D regeneration of tissue.

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Bioactive antibacterial silica-based nanocomposites hydrogel scaffolds with high angiogenesis for promoting diabetic wound healing and skin repair

Cited by 169 publications

References 41 publications

Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis

Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis

Electrospun fibrous sponge via short fiber for mimicking 3D ECM

Electrospun Fibrous Sponge via Short Fiber for Mimicking 3D ECM

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