Bioactivity-Guided Isolation of Acetylcholinesterase Inhibitor from Ganoderma mediosinense (Agaricomycetes)

Kaur, Arshdeep; Randhawa, Kudrat; Singh, Varinder; Shri, Richa

doi:10.1615/intjmedmushrooms.2019031508

Cited by 14 publications

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“…For example, Zengin et al [ 26 ] reported that the water and methanolic extracts of two Ganoderma species ( G. applanatum and G. resinaceum ) inhibited AChE (0.62–1.47 mg GALAE/g) and BChE (0.70–2.94 mg GALAE/g). Some authors have also isolated some anticholinesterase agents from specimens of Ganoderma [ 35 , 36 ]. Altogether, the members of the genus Ganoderma could be valuable candidates as sources of natural cholinesterase inhibitors for the development of anti-Alzheimer’s disease drugs.…”

Section: Resultsmentioning

confidence: 99%

Bioactivity and Mycochemical Profile of Extracts from Mycelial Cultures of Ganoderma spp.

et al. 2022

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Fungal mycelium cultures are an alternative to natural sources in order to obtain valuable research materials. They also enable constant control and adaptation of the process, thereby leading to increased biomass growth and accumulation of bioactive metabolites. The present study aims to assess the biosynthetic potential of mycelial cultures of six Ganoderma species: G. adspersum, G. applanatum, G. carnosum, G. lucidum, G. pfeifferi, and G. resinaceum. The presence of phenolic acids, amino acids, indole compounds, sterols, and kojic acid in biomass extracts was determined by HPLC. The antioxidant and cytotoxic activities of the extracts and their effects on the inhibition of selected enzymes (tyrosinase and acetylcholinesterase) were also evaluated. The total content of phenolic acids in the extracts ranged from 5.8 (G. carnosum) to 114.07 mg/100 g dry weight (d.w.) (G. pfeifferi). The total content of indole compounds in the extracts ranged from 3.03 (G. carnosum) to 11.56 mg/100 g d.w. (G. lucidum) and that of ergosterol ranged from 28.15 (G. applanatum) to 74.78 mg/100 g d.w. (G. adspersum). Kojic acid was found in the extracts of G. applanatum and G. lucidum. The tested extracts showed significant antioxidant activity. The results suggest that the analyzed mycelial cultures are promising candidates for the development of new dietary supplements or pharmaceutical preparations.

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Section: Resultsmentioning

confidence: 99%

Bioactivity and Mycochemical Profile of Extracts from Mycelial Cultures of Ganoderma spp.

et al. 2022

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“…The latter reacts with 5, 5'-dithiobis (2-nitrobenzoic acid) (DTNB), thereby producing 2-nitrobenzoate-5mercaptothiocholine and %-thio-2-nitrobenzoate, which can be detected at 412 nm. All the readings were taken in triplicate 11,45,46 .…”

Section: In-vitro Acetylcholinesterase (Ache) Inhibitory Activitymentioning

confidence: 99%

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2022

IJPSR

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Environmental factors influence plant growth, morphology, as well as nature and quantity of secondary metabolites. Modification of abiotic factors during plant growth can impact the production of bioactive phytoconstituents. A six-month field study was carried out to assess the effect of different abiotic stresses on bioactive compounds (flavonoids, phenols, quercetin), acetylcholine sterase (AChE) inhibition and antioxidant capacity of two selected Allium species i.e. Allium cepa L. (AC) & Allium sativum L. (AS; family Amaryllidaceae). AC and AS plants were grown for six months (from November 2018 to April 2019) on three different soil types (i.e. black, red, clay-loamy) and various stresses (salinity, water deprivation, flooding, fertilizer, metal, shade) were applied on the plants. At the end of the season, plants were collected, dried and plant yield was determined. Hydro alcoholic extracts of all samples were prepared. Extract yield, total flavonoids (TFC), total phenols (TPC), AChE inhibition, and antioxidant activity were determined in all the extracts. The results show the varied response of AC & AS plants to different soil types and stresses. AS plants grown in red soil with salt stress and AC plants on red soil with fertilization give higher biomass yield. AC plants grown in black soil and AS in red soil under metal stress have the highest TFC, TPC, AChE inhibition, and antioxidant activity. Hence these conditions may be recommended for incorporation in cultivation practices of these valuable medicinal plants. This would ensure a commercial supply of plants with higher phenol and flavonoid content and better activity. INTRODUCTION: Onions Allium cepa L. (AC) and garlic Allium sativum L. (AS) are highly valued members of the genus Allium (Family Amaryllidaceae) 1 . AC and AS are considered imperative dietary components due to their unique QUICK RESPONSE CODE

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Improvement of cognitive function in mice by Citrus reticulata var. kinnow via modulation of central cholinergic system and oxidative stress

et al. 2021

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Bioactivity-Guided Isolation of Acetylcholinesterase Inhibitor from Ganoderma mediosinense (Agaricomycetes)

Cited by 14 publications

References 0 publications

Bioactivity and Mycochemical Profile of Extracts from Mycelial Cultures of Ganoderma spp.

Bioactivity and Mycochemical Profile of Extracts from Mycelial Cultures of Ganoderma spp.

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Improvement of cognitive function in mice by Citrus reticulata var. kinnow via modulation of central cholinergic system and oxidative stress

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