Bioadhesive‐based dosage forms: The next generation

Lee, Jin Whan; Park, Jae‐Han; Robinson, Joseph R.

doi:10.1002/1520-6017(200007)89:7<850::aid-jps2>3.3.co;2-7

Cited by 83 publications

(113 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Lectins can increase the adherence of microparticules to the intestinal epithelium and enhance penetration of drugs. 24) They may be used to target therapeutic agents for different gut components or even for different cells (e.g. complex-specific lectins for parietal cells or fucose-specific Galanthus nivalis agglutinin (GNA) Epithelial cells in stomach, caecum, and colon 2 N-Acetyl Wheat germ agglutinin (WGA) Epithelial cells in stomach, caecum, colon and absorptive glucosamine 57) enterocytes in small intestine Lycopersicon esculentum or tomato Strong binding to M cells lectin (LEA) 3 N-Acetyl Lectin ML-1 from Visum album Endocytosed by villus enterocytes and goblet cells strong glucosamine 58) binding to epithelial cells in small intestine 4 P h ytohaemagglutinin 59) Phaseolus vulgaris isoagglutinin Surface cells of the stomach 5 Fucose 60) Aleuria aurentia agglutinin (AAA) Specific binding and transcytosis by M cells lectins for M cells).…”

Section: Specific Site Directed Bioadhesives-the Next Generationmentioning

confidence: 99%

“…34) Thus, the DDS based on bacterial adhesion factors could be an efficient mechanism to increase adhesion of mucoadhesive microspheres to epithelial surfaces. 24) Another study 35) envisaging the importance of bacterial adhesion has been carried out using "invasion," which is a membrane protein from Yersinia pseudotuberculosis. Cellular uptake of polymeric nanospheres functionalized with invasion has been observed using confocal laser scanning microscopy.…”

Section: )mentioning

confidence: 99%

See 1 more Smart Citation

Mucoadhesive Microspheres for Controlled Drug Delivery

Chowdary

Rao

2004

Biological & Pharmaceutical Bulletin

155

View full text Add to dashboard Cite

Mucoadhesion is a topic of current interest in the design of drug delivery systems. Mucoadhesive microspheres exhibit a prolonged residence time at the site of application or absorption and facilitate an intimate contact with the underlying absorption surface and thus contribute to improved and/or better therapeutic performance of drugs. In recent years such mucoadhesive microspheres have been developed for oral, buccal, nasal, ocular, rectal and vaginal routes for either systemic or local effects. The objective of this article is review the principles underlying the development and evaluation of mucoadhesive microspheres and the research work carried out on these systems.

show abstract

Section: Specific Site Directed Bioadhesives-the Next Generationmentioning

confidence: 99%

Section: )mentioning

confidence: 99%

Mucoadhesive Microspheres for Controlled Drug Delivery

Chowdary

Rao

2004

Biological & Pharmaceutical Bulletin

155

View full text Add to dashboard Cite

show abstract

“…[4][5][6][7][8] Attention has been given to improving the paracellular transport of hydrophilic macromolecules. 9 The transport of hydrophilic macromolecules via the paracellular pathways is, however, severely restricted by the presence of tight junctions, which are located at the luminal aspect of adjacent epithelial cells.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Nanoparticles Shelled with Chitosan for Oral Insulin Delivery

et al. 2006

View full text Add to dashboard Cite

Nanoparticles (NPs) composed of chitosan (CS) and poly(γ-glutamic acid) (γ-PGA) were prepared by a simple ionic-gelation method for oral insulin delivery. Fourier transform infrared (FT-IR) spectra indicated that CS and γ-PGA were ionized at pH 2.5-6.6, while X-ray diffractograms demonstrated that the crystal structure of CS was disrupted after it was combined with γ-PGA. The diameters of the prepared NPs were in the range of 110-150 nm with a negative or positive surface charge, depending on the relative concentrations of CS to γ-PGA used. The NPs with a positive surface charge (or shelled with CS) could transiently open the tight junctions between Caco-2 cells and thus increased the paracellular permeability. After loading of insulin, the NPs remained spherical and the insulin release profiles were significantly affected by their stability in distinct pH environments. The in vivo results clearly indicated that the insulin-loaded NPs could effectively reduce the blood glucose level in a diabetic rat model.

show abstract

“…Recent years have seen an increasing interest in the development of novel buccal bioadhesive dosage forms including bioadhesive tablets, gels and films. 6) However, buccal bioadhesive films are preferable over buccal bioadhesive tablets in terms of flexibility and comfort. 7) These buccal bioadhesive films are useful for both for systemic delivery of drugs, as well as for local targeting of drugs to a particular region in the body.…”

mentioning

confidence: 99%

“…7) These buccal bioadhesive films are useful for both for systemic delivery of drugs, as well as for local targeting of drugs to a particular region in the body. 6,8) A wide range of polymers of synthetic, semi synthetic and natural origin like Carbopol, Polycarbophil, sodium carboxymethylcellulose (SCMC), hydroxypropylmethylcellulose, chitosan and xanthan gum have been described for the formulation of bioadhesive systems but none of these polymer possess all the characteristics of an ideal polymer (nontoxic, nonirritant, strong non covalent adhesion, sustained release, stable and cheap) for a bioadhesive drug delivery system. 8) Carbopols are excellent bioadhesives but with potential mucosal irritating character.…”

mentioning

confidence: 99%

In Vitro and in Vivo Evaluation of Buccal Bioadhesive Films Containing Salbutamol Sulphate

Singh

Soni

Rawat

et al. 2010

CHEMICAL & PHARMACEUTICAL BULLETIN

View full text Add to dashboard Cite

The aim of present study was to prepare and evaluate buccal bioadhesive films of salbutamol sulphate (SS) for the treatment of asthma. The films were designed to release the drug for a prolonged period of time so as to reduce the frequency of administration of the available conventional dosage forms of SS. The different proportions of sodium carboxymethylcellulose (SCMC) and Carbopol 940P (CP 940P) were used for the preparation of films. Carbopol was used to incorporate the desired bioadhesiveness in the films. The films were prepared by solvent casting method and evaluated for bioadhesion, in vitro drug release and anti asthmatic effect (bronchoprotection) in histamine induced bronchospasm of guinea pigs. In vitro drug release from the film was determined using a modified Franz diffusion cell while bioadhesiveness was evaluated with a modified two-arm balance using guinea pig buccal mucosa as a model tissue. Films containing SCMC : CP 940P ratio of 76 : 24 was found to be the best with moderate swelling along with favorable bioadhesion force and in vitro drug release. The drug release mechanism was found to follow non-Fickian diffusion as release mechanism. The prolonged in vivo effect (bronchoprotection) obtained from the buccal bioadhesive film of SS administered via buccal route may improve the treatment of asthmatic disorders by reducing the frequency of administration which is associated with the tolerance effect of SS. Additionally for the clinical benefit, it is also expected to reduce the major adverse effects of SS such as tachycardia and arrhythmias via buccal absorption.Key words salbutamol sulphate; buccal bioadhesive film; Carbopol 940P; in vivo effect Chem. Pharm. Bull. 58(3) 307-311 (2010)

show abstract

Bioadhesive‐based dosage forms: The next generation

Cited by 83 publications

References 0 publications

Mucoadhesive Microspheres for Controlled Drug Delivery

Mucoadhesive Microspheres for Controlled Drug Delivery

Preparation and Characterization of Nanoparticles Shelled with Chitosan for Oral Insulin Delivery

In Vitro and in Vivo Evaluation of Buccal Bioadhesive Films Containing Salbutamol Sulphate

Contact Info

Product

Resources

About