Biochemical functionality of magnetic particles as nanosensors: how far away are we to implement them into clinical practice?

Doswald, Simon; Stark, Wendelin J.; Beck‐Schimmer, Beatrice

doi:10.1186/s12951-019-0506-y

Cited by 24 publications

(11 citation statements)

References 109 publications

(85 reference statements)

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“…Nanorobots may contribute to generating scientific data concerning how does neurophysiology strengthens during therapy and help for more accurate diagnoses. Nanosensors test the efficacy of certain drugs and able to provide feedback on the drug's efficacy, potency, and effects 108 . Nanosensors contribute in-depth concerning the antidepressant mechanism and psychotropic pathways offer entire patient-specific data.…”

Section: The Monitoring Of the Drug Release Vivo mentioning

confidence: 99%

Review of nanotheranostics for molecular mechanisms underlying psychiatric disorders and commensurate nanotherapeutics for neuropsychiatry: The mind knockout

Kumar¹,

Chhikara²,

Gulia³

et al. 2021

Nanotheranostics

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Bio-neuronal led psychiatric abnormalities transpired by the loss of neuronal structure and function (neurodegeneration), pro-inflammatory cytokines, microglial dysfunction, altered neurotransmission, toxicants, serotonin deficiency, kynurenine pathway, and excessively produced neurotoxic substances. These uncontrolled happenings in the etiology of psychiatric disorders initiate further changes in neurotransmitter metabolism, pathologic microglial, cell activation, and impaired neuroplasticity. Inflammatory cytokines, the outcome of dysfunctional mitochondria, dysregulation of the immune system, and under stress functions of the brain are leading biochemical factors for depression and anxiety. Nanoscale drug delivery platforms, inexpensive diagnostics using nanomaterials, nano-scale imaging technologies, and ligand-conjugated nanocrystals used for elucidating the molecular mechanisms and foremost cellular communications liable for such disorders are highly capable features to study for efficient diagnosis and therapy of the mental illness. These theranostic tools made up of multifunctional nanomaterials have the potential for effective and accurate diagnosis, imaging of psychiatric disorders, and are at the forefront of leading technologies in nanotheranostics openings field as they can collectively and efficiently target the stimulated territories of the cerebellum (cells and tissues) through molecular-scale interactions with higher bioavailability, and bio-accessibility. Specifically, the nanoplatforms based neurological changes are playing a significant role in the diagnosis of psychiatric disorders and portraying the routes of functional restoration of mental disorders by newer imaging tools at nano-level in all directions. Because of these nanotherapeutic platforms, the molecules of nanomedicine can penetrate the Blood-Brain Barrier with an increased half-life of drug molecules. The discoveries in nanotheranostics and nanotherapeutics inbuilt unique multi-functionalities are providing the best multiplicities of novel nanotherapeutic potentialities with no toxicity concerns at the level of nano range.

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Section: The Monitoring Of the Drug Release Vivo mentioning

confidence: 99%

Review of nanotheranostics for molecular mechanisms underlying psychiatric disorders and commensurate nanotherapeutics for neuropsychiatry: The mind knockout

Kumar¹,

Chhikara²,

Gulia³

et al. 2021

Nanotheranostics

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“…In microfluidic devices, the property of MNPs to be functionalized is used to achieve specific bioanalytical tasks. MNPs are nontoxic and well tolerated by living organisms, therefore, appropriate for bioapplications [64]. They can be synthesized in nanometer range by the different process making them ideal for probing and manipulating biomolecules with minimum undesirable interactions [65].…”

Section: Properties Of Magnetic Nanoparticles (Mnps)mentioning

confidence: 99%

Magnetic nanoparticles in microfluidic and sensing: From transport to detection

et al. 2020

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Superparamagnetic nanoparticles are attracting significant attention. Therefore, being explored in microsystems for a wide range of applications. Typical examples include labon-a-chip and microfluidics for synthesis, detection, separation, and transportation of different bioanalytes, such as biomolecules, cells, and viruses to develop portable, sensitive, and cost-effective biosensing systems. Particularly, microfluidic systems incorporated with magnetic nanoparticles and, in combination with magnetoresistive sensors, shift diagnostic and analytical methods to a microscale level. In this context, nanotechnology enables the miniaturization and integration of a variety of analytical functions in a single chip for manipulation, detection, and recognition of bioanalytes reliably and flexibly. In consideration of the above, recent development and benefits are elaborated herein to discuss the role of magnetic nanoparticles inside the microchannels to design highly efficient disposable point-of-care applications from transportation to the detection of bioanalytes.

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“…This opened the door to a range of medical applications, including transformative technologies for point of care monitoring and diagnostics devices. It's thus a timely occasion to review the successes of nanoparticles and sensors tailored to serve highly specific functions, from medical applications [2][3][4][5][6] to sensing the environment [7][8][9][10][11][12], as well as to ask where and when caution is warranted [13][14][15][16][17][18][19][20][21][22][23].…”

Section: Assessing the Progress Madementioning

confidence: 99%

Nanosensors and particles: a technology frontier with pitfalls

Vogel

2019

J Nanobiotechnol

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As we are approaching 20 years after the US National Nanotechnology Initiative has been announced, whereby most of that funding was spend to engineer, characterize and bring nanoparticles and nanosensors to the market, it is timely to assess the progress made. Beyond revolutionizing nonmedical applications, including construction materials and the food industry, as well as in vitro medical diagnostics, the progress in bringing them into the clinic has been far slower than expected. Even though most of the advances in nanosensor and nanoparticle research and development have been paid for by disease-oriented funding agencies, much of the gained knowledge can now be applied to treat or learn more about our environment, including water, soil, microbes and plants. As the amount of engineered nanoparticles that enter our environment is currently exponentially increasing, much tighter attention needs to be paid to assessing their health risk. This is urgent as the asbestos story told us important lessons how financial interests arising from a rapid build up of a flourishing industry has blocked and is still preventing a worldwide ban on asbestos, nearly 100 years after the first health risks were reported.

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Biochemical functionality of magnetic particles as nanosensors: how far away are we to implement them into clinical practice?

Cited by 24 publications

References 109 publications

Review of nanotheranostics for molecular mechanisms underlying psychiatric disorders and commensurate nanotherapeutics for neuropsychiatry: The mind knockout

Review of nanotheranostics for molecular mechanisms underlying psychiatric disorders and commensurate nanotherapeutics for neuropsychiatry: The mind knockout

Magnetic nanoparticles in microfluidic and sensing: From transport to detection

Nanosensors and particles: a technology frontier with pitfalls

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