Biogenic silver nanoparticles reduce adherence, infection, and proliferation of toxoplasma gondii RH strain in HeLa cells without inflammatory mediators induction

Machado, Laís Fernanda; Sanfelice, Raquel Arruda; Bosqui, Larissa Rodrigues; Assolini, João Paulo; Scandorieiro, Sara; Navarro, Italmar Teodorico; Cataneo, Allan Henrique Depieri; Wowk, Pryscilla Fanini; Nakazato, Gerson; Bordignon, Juliano; Pavanelli, Wander Rogério; Conchon‐Costa, Ivete; Costa, Idessânia Nazareth

doi:10.1016/j.exppara.2020.107853

Cited by 27 publications

(15 citation statements)

References 65 publications

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“…They revealed that bio-AgNPs effectively reduced adherence, infection, and proliferation of tachyzoites in HeLa cells at concentrations of 3 and 6 µM when compared with a conventional drug. Bio-AgNPs at the concentrations tested were not able to induce ROS production in HeLa cells infected with T. gondii [172].…”

Section: Antiprotozoal Activitymentioning

confidence: 82%

“…Biogenic AgNPs are considered as efficient agents against the protozoan parasites responsible for causing zoonoses in humans-namely, Leishmania amazonensis and Toxoplasma gondii [121,172]. Leishmania causes zoonosis called American Cutaneous Leishmaniasis (ACL) which is known to be difficult to treat with available chemotherapy.…”

Section: Antiprotozoal Activitymentioning

confidence: 99%

“…However, the authors suggested further in vivo investigations for a possible bio-AgNP treatment for ACL [121]. In another study, Machado et al [172] claimed that bio-AgNPs synthesized from F. oxysporum can be used as a therapeutic alternative for toxoplasmosis caused by T. gondii. They revealed that bio-AgNPs effectively reduced adherence, infection, and proliferation of tachyzoites in HeLa cells at concentrations of 3 and 6 µM when compared with a conventional drug.…”

Section: Antiprotozoal Activitymentioning

confidence: 99%

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Biogenic Silver Nanoparticles: What We Know and What Do We Need to Know?

et al. 2021

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Nanobiotechnology is considered to be one of the fastest emerging fields. It is still a relatively new and exciting area of research with considerable potential for development. Among the inorganic nanomaterials, biogenically synthesized silver nanoparticles (bio-AgNPs) have been frequently used due to their unique physicochemical properties that result not only from their shape and size but also from surface coatings of natural origin. These properties determine antibacterial, antifungal, antiprotozoal, anticancer, anti-inflammatory, and many more activities of bio-AgNPs. This review provides the current state of knowledge on the methods and mechanisms of biogenic synthesis of silver nanoparticles as well as their potential applications in different fields such as medicine, food, agriculture, and industries.

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Section: Antiprotozoal Activitymentioning

confidence: 82%

Section: Antiprotozoal Activitymentioning

confidence: 99%

Section: Antiprotozoal Activitymentioning

confidence: 99%

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Biogenic Silver Nanoparticles: What We Know and What Do We Need to Know?

et al. 2021

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“…Furthermore, their anti-protozoal activity has been confirmed against Toxoplasma gondii , Echinococcus granulosus , Schistosoma japonicum , Giardia intestinalis , Entamoeba histolytica , Leishmania spp., and Plasmodium spp. [ 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. The efficacy of AgNPs against Acanthamoeba spp.…”

Section: Introductionmentioning

confidence: 99%

Silver Nanoparticles Conjugated with Contact Lens Solutions May Reduce the Risk of Acanthamoeba Keratitis

Hendiger

Padzik

Sifaoui³

et al. 2021

Pathogens

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Acanthamoeba keratitis (AK), a severe sight-threatening corneal infection, has become a significant medical problem, especially among contact lens wearers. The disease manifests as eye pain, congestion, blurred vision, lachrymation, and ring-shaped infiltrates of the cornea, and can lead to permanent blindness. Inappropriate habits of contact lens users may result in an increased risk of AK infection. The anti-amoebic efficiency of popular multipurpose contact lens solutions is insufficient to reduce this risk. An effective and non-toxic therapy against AK has not yet been developed. The prevention of AK is crucial to reduce the number of AK infections. Nanoparticles are known to be active agents against bacteria, viruses, and fungi and were also recently tested against protozoa, including Acanthamoeba spp. In our previous studies, we proved the anti-amoebic and anti-adhesive activity of silver nanoparticles against Acanthamoeba castellanii. The aim of this study is to evaluate the activity, cytotoxicity, and anti-adhesive properties of silver nanoparticles conjugated with five commonly used multipurpose contact lens solutions against the Acanthamoeba castellanii NEFF strain. The obtained results show a significant increase in anti-amoebic activity, without increasing the overall cytotoxicity, of Solo Care Aqua and Opti Free conjugated with nanoparticles. The adhesion of Acanthamoeba trophozoites to the contact lens surface is also significantly reduced. We conclude that low concentrations of silver nanoparticles can be used as an ingredient in contact lens solutions to decrease the risk of Acanthamoeba keratitis infection.

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“…gondii, a expressão de IL-8 é aumentada (MACHADO et al, 2020;MILIAN et al, 2019;PARK et al, 2019). Isso também é observado durante a gestação, já que mulheres grávidas infectadas com T. gondii apresentaram níveis aumentados de IL-8 (NEJAD et al, 2011).…”

Section: Discussionunclassified

Galectina-3 controla a proliferação intracelular de Toxoplasma gondii em células trofoblásticas humanas (linhagem BeWo)

Ribeiro¹

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Biogenic silver nanoparticles reduce adherence, infection, and proliferation of toxoplasma gondii RH strain in HeLa cells without inflammatory mediators induction

Cited by 27 publications

References 65 publications

Biogenic Silver Nanoparticles: What We Know and What Do We Need to Know?

Biogenic Silver Nanoparticles: What We Know and What Do We Need to Know?

Silver Nanoparticles Conjugated with Contact Lens Solutions May Reduce the Risk of Acanthamoeba Keratitis

Galectina-3 controla a proliferação intracelular de Toxoplasma gondii em células trofoblásticas humanas (linhagem BeWo)

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