Biological Properties of Acidic Cosmetic Water from Seawater

Abstract

This current work was to investigate the biological effects of acidic cosmetic water (ACW) on various biological assays. ACW was isolated from seawater and demonstrated several bio-functions at various concentration ranges. ACW showed a satisfactory effect against Staphylococcus aureus, which reduced 90% of bacterial growth after a 5-second exposure. We used cultured human peripheral blood mononuclear cells (PBMCs) to test the properties of ACW in inflammatory cytokine release, and it did not induce inflammatory cytokine release from un-stimulated, normal PBMCs. However, ACW was able to inhibit bacterial lipopolysaccharide (LPS)-induced inflammatory cytokine TNF-α released from PBMCs, showing an anti-inflammation potential. Furthermore, ACW did not stimulate the rat basophilic leukemia cell (RBL-2H3) related allergy response on de-granulation. Our data presented ACW with a strong anti-oxidative ability in a superoxide anion radical scavenging assay. In mass spectrometry information, magnesium and zinc ions demonstrated bio-functional detections for anti-inflammation as well as other metal ions such as potassium and calcium were observed. ACW also had minor tyrosinase and melanin decreasing activities in human epidermal melanocytes (HEMn-MP) without apparent cytotoxicity. In addition, the cell proliferation assay illustrated anti-growth and anti-migration effects of ACW on human skin melanoma cells (A375.S2) indicating that it exerted the anti-cancer potential against skin cancer. The results obtained from biological assays showed that ACW possessed multiple bioactivities, including anti-microorganism, anti-inflammation, allergy-free, antioxidant, anti-melanin and anticancer properties. To our knowledge, this was the first report presenting these bioactivities on ACW.

Antimelanoma and Antityrosinase from Alpinia galangal Constituents

“…The melanogenesis pathway consists of the enzymatic L-tyrosine hydroxylation and the oxidation of L-dopa to its corresponding dopaquinone [9]. After the two tyrosinase-catalyzed steps, additional multiple biosynthesis steps followed and yielded melanin [10].…”

“…However, only a few are used as therapeutic agents, primarily because of various safety concerns and low whitening bioactivity. In melanogenesis, L-tyrosine is hydroxylated to dihydroxyphenylalanine (L-DOPA), and then L-DOPA is oxidized to DOPA-quinone with two initial steps [9]. Pigment coloring hair, skin, and eyes because of the key protein, tyrosinase, is recognized to be the first two and rate-limiting enzyme in the biosynthesis of melanins [10].…”

Biofunctional Constituents from Liriodendron tulipifera with Antioxidants and Anti-Melanogenic Properties

“…The melanogenesis pathway consists of the enzymatic L-tyrosine hydroxylation and the oxidation of L-dopa to its corresponding dopaquinone. After the two tyrosinase-catalyzed steps, additional multiple biosynthesis steps followed and yield melanin [17]. L. tulipifera compounds were investigated for mouse B16F10 cellular tyrosinase-inhibiting abilities (Figure 3A) and melanin content (Figure 3B) decreasing powers.…”

“…In recent years, ingesting fresh fruits, vegetables or teas to acquire natural antioxidants have been purported to benefit human health. Dietary strategies are considered important to prevent diseases [16,17]. Natural antioxidant constituents, capable of lowering free radical mediated degradations of cells and tissues in human organism, are very substantial in cosmetics or food businesses [18,19].…”

Functional Ginger Extracts from Supercritical Fluid Carbon Dioxide Extraction via In Vitro and In Vivo Assays: Antioxidation, Antimicroorganism, and Mice Xenografts Models

“…Therefore, the research requirements for new anti-infection therapeutic agents have increased in natural medicinal therapies. The utilization of plant-derived constitutes as preservatives, cosmetics, and pharmaceuticals has recently attracted increased interests [6]. …”