2010
DOI: 10.1615/critrevimmunol.v30.i2.70
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Biomarkers for Serum Diagnosis of Infectious Diseases and Their Potential Application in Novel Sensor Platforms

Abstract: Nanotechnological tools and biomarkers for diagnosis and prognosis, as well as strategies for disease control and monitoring populations at higher risk, are continuous worldwide challenges for infectious diseases. Phage display and monoclonal antibody combinatorial libraries are important sources for biomarker discovery and for improved diagnostic strategies. Mimetic peptides were selected against polyclonal antibodies from patients with dengue fever, leprosy, and leishmaniasis as model diseases, and from immu… Show more

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Cited by 58 publications
(32 citation statements)
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“…These techniques have a high cost, demanding skilled labor and time-consuming analysis [9–12]. Other recent technologies, such as the development of biosensors, are emerging and may revolutionize the disease diagnosis [13]. Generally, electrochemical biosensors have high sensitivity and low-cost, having superior properties when compared to alternative analytical techniques [1416].…”
Section: Introductionmentioning
confidence: 99%
“…These techniques have a high cost, demanding skilled labor and time-consuming analysis [9–12]. Other recent technologies, such as the development of biosensors, are emerging and may revolutionize the disease diagnosis [13]. Generally, electrochemical biosensors have high sensitivity and low-cost, having superior properties when compared to alternative analytical techniques [1416].…”
Section: Introductionmentioning
confidence: 99%
“…A highly specific and sensitive-constrained synthetic peptide (LC2) derived from a mimotope of Leishmania chagasi antigen, selected by phage display (is a selection technique in which a library of peptide or protein variants is expressed as a genetic fusion to a bacteriophage coat protein), was used as probe for IgG detection [4] were synthesized and pre-validated by the enzyme-linked immunosorbent assay (ELISA) method. Phosphate buffer saline solution (pH 7.4) was used as the baseline.…”
Section: Methodsmentioning
confidence: 99%
“…The methods currently employed in visceral leishmaniasis clinical diagnoses are costly, requiring numerous steps to perform besides specialized labor, have also shown low sensitivity to detect the initial cases of the disease, generating false negatives for the disease. Therefore, it is clear the need to develop methodologies that allow a more sensitive and faster diagnosis, guaranteeing greater control of visceral leishmaniasis [3,4].…”
Section: General Aspects Of Leishmaniasismentioning
confidence: 99%
“…As mentioned in previous points, micro-and nanotechnologies can offer new technological tools and potential applications for developing bio-sensing devices for infection´s biomarkers. Many of these biosensors have proven to be useful for the detection of pathogen signatures and circulating proteins in patients [118]. The access to timely and accurate diagnostic tests has a significant impact in the management of many parasitic diseases like malaria.…”
Section: The Critical Role Of Biosensors In Important Parasitic Diseamentioning
confidence: 99%