Biomarkers of nephrotoxicity in children environmentally exposed to lead in Poland

Osman, Katarina; Elinder, Carl Gustaf; Schütz, Andrejs; Grubb, Anders

doi:10.1002/(sici)1099-1301(199901/03)1:1<33::aid-jem7>3.0.co;2-k

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Cited by 9 publications

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“…24 A study in Poland in 1999 found that lead-exposed children have glomerular and tubular renal dysfunction. 4 Recent study with larger samples in the United States in 2011 concluded that higher BLL was associated with decreased GFR and increased cystatin-C level, and was a risk factor for chronic renal failure. 25 A correlation between lead and cystatin-C, a marker of early renal damage with lead poisoning, has been widely studied, but the study has been limited to adult subjects.…”

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confidence: 99%

“…A study in Poland concluded that children exposed to lead may exhibit glomerular and tubular renal dysfunction. 4 Serum creatinine is neither a sensitive nor specific examination for diagnosing acute kidney injury (AKI). 5 Many studies have shown serum cystatin-C levels to be a better indicator of GFR compared to serum creatinine levels, making it more sensitive as a marker for changes in renal function.…”

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confidence: 99%

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