Biomarkers: paving stones on the road towards the personalized precision medicine for oral squamous cell carcinoma

Zhong, Liang; Liu, Yutong; Wang, Kai; He, Zhijing; Gong, Zhaojian; Zhao, Zhiling; Yang, Yi; Gao, Xiaofei; Li, Fangjie; Wu, Hanjiang; Zhang, Sheng; Chen, Lin

doi:10.1186/s12885-018-4806-7

Cited by 32 publications

(20 citation statements)

References 164 publications

(161 reference statements)

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“…At present, there are few biomarkers or targets for OSCC diagnosis and treatment. Therefore, identifying genes which have different expression patterns in OSCC tumors and normal tissues should help elucidate the pathogenesis of OSCC and may provide useful diagnostic biomarkers and therapeutic targets for OSCC treatment [40].…”

Section: Discussionmentioning

confidence: 99%

Decreased Cytoplasmic Expression of ADAMTS14 Is Correlated with Reduced Survival Rates in Oral Squamous Cell Carcinoma Patients

Lin

et al. 2020

Diagnostics

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A disintegrin and metalloproteinase with thrombospondin motif 14 (ADAMTS14) is a member of the zinc-dependent protease family that is implicated in the occurrence and progression of tumors. Oral cancer (OC) is a common cancer worldwide, but it is particularly prevalent in Taiwan. However, whether the expression of ADAMTS14 is correlated with the carcinogenesis and progression of oral squamous cell carcinoma (OSCC) has not yet been investigated. In this study, we used immunohistochemistry (IHC) to examine 250 OSCC specimens in order to identify correlations between the cytoplasmic expression of ADAMTS14 and (1) clinicopathological features of OSCC as well as (2) clinical outcomes of OSCC. Our results indicate that cytoplasmic expression of ADAMTS14 was lower in OSCC tissues than in normal tissues. In analyzing correlations between ADAMTS14 expression and clinicopathological features, we found that negative cytoplasmic expression of ADAMTS14 was significantly associated with higher frequencies of lymph node metastasis and more advanced AJCC stages (III/IV). Kaplan–Meier survival analysis revealed that negative cytoplasmic expression of ADAMTS14 was also associated with significantly worse OSCC survival. Univariate and multivariate analyses confirmed that cytoplasmic expression of ADAMTS14 was associated with lymph node metastasis, tumor stage, and tumor grade and also indicated that cytoplasmic ADAMTS14 expression may be an independent prognostic factor for OSCC. This is the first study to report that the cytoplasmic expression level of ADAMTS14 is associated with OSCC prognosis and tumor progression. Our data indicate that ADAMTS14 can serve as a prognostic marker and a potential therapeutic target for OSCC.

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Section: Discussionmentioning

confidence: 99%

Decreased Cytoplasmic Expression of ADAMTS14 Is Correlated with Reduced Survival Rates in Oral Squamous Cell Carcinoma Patients

Lin

et al. 2020

Diagnostics

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“…Biomarkers refer to "biomolecules identified in blood, other body fluids, or tissues that indicate normal or abnormal processes, conditions, or diseases, and can be used to observe the body's response to treatments for diseases or conditions" [121]. Studies have investigated the use of nucleic acid and protein changes in saliva, blood, and tissue samples as biomarkers to improve the diagnosis and prognosis of OSCC [122]. Numerous studies have demonstrated that the loss of specific chromosomal regions in known or speculated tumor suppressor genes can be used as an early predictor of the subsequent progression of oral precancerous lesions [123].…”

Section: Biomarkersmentioning

confidence: 99%

The Potential of Phytochemicals in Oral Cancer Prevention and Therapy: A Review of the Evidence

Lee

Tseng

2020

Biomolecules

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The etiological factors of oral cancer are complex including drinking alcohol, smoking tobacco, betel quid chewing, human papillomavirus infection, and nutritional deficiencies. Understanding the molecular mechanism of oral cancer is vital. The traditional treatment for patients with oral squamous cell carcinoma (e.g., surgery, radiotherapy, and chemotherapy) and targeted molecular therapy still have numerous shortcomings. In recent years, the use of phytochemical factors to prevent or treat cancer has received increasing attention. These phytochemicals have little or no toxicity against healthy tissues and are thus ideal chemopreventive agents. However, phytochemicals usually have low water solubility, low bioavailability, and insufficient targeting which limit therapeutic use. Numerous studies have investigated the development of phytochemical delivery systems to address these problems. The present article provides an overview of oral cancer including the etiological factors, diagnosis, and traditional therapy. Furthermore, the classification, dietary sources, anticancer bioactivity, delivery system improvements, and molecular mechanisms against oral cancer of phytochemicals are also discussed in this review.

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“…However, research has also reported that the global OC genome is hypomethylated and increasingly hypomethylated in univariate association with tobacco/alcohol history and the malignant stage of the tumor [64,65]. Nevertheless, the individual DNA methylotype maintains translational interest for molecular staging, prognosis and customized management of OC patients [66,67,68,69]. In support of this are the recent results obtained by connecting the alteration of the DNA methylotype of HNC patients with gene expression profiling to screen their biomarker potency [70,71].…”

Section: Epigenetic Regulation Of Melatonin In Oral Cancermentioning

confidence: 99%

Potential of Melatonin as Adjuvant Therapy of Oral Cancer in the Era of Epigenomics

Capote-Moreno

Ramos

Egea

et al. 2019

Cancers

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The wide variety of epigenetic controls available is rapidly expanding the knowledge of molecular biology even overflowing it. At the same time, it can illuminate unsuspected ways of understanding the etiology of cancer. New emerging therapeutic horizons, then, promise to overcome the current antitumor strategies need. The translational utility of this complexity is particularly welcome in oral cancer (OC), in which natural history is alarmingly disappointing due to the invasive and mutilating surgery, the high relapsing rate, the poor quality of life and the reduced survival after diagnosis. Melatonin activates protective receptor-dependent and receptor-independent processes that prevent tissue cancerisation and inhibit progressive tumor malignancy and metastasis. Related evidence has shown that melatonin pleiotropy encompasses gene expression regulation through all the three best-characterized epigenetic mechanisms: DNA methylation, chromatin modification, and non-coding RNA. OC has received less attention than other cancers despite prognosis is usually negative and there are no significant therapy improvements recorded in the past decade. However, a large research effort is being carried out to elucidate how melatonin´s machinery can prevent epigenetic insults that lead to cancer. In the light of recent findings, a comprehensive examination of biochemistry through which melatonin may reverse epigenetic aberrations in OC is an extraordinary opportunity to take a step forward in the clinical management of patients.

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Biomarkers: paving stones on the road towards the personalized precision medicine for oral squamous cell carcinoma

Cited by 32 publications

References 164 publications

Decreased Cytoplasmic Expression of ADAMTS14 Is Correlated with Reduced Survival Rates in Oral Squamous Cell Carcinoma Patients

Decreased Cytoplasmic Expression of ADAMTS14 Is Correlated with Reduced Survival Rates in Oral Squamous Cell Carcinoma Patients

The Potential of Phytochemicals in Oral Cancer Prevention and Therapy: A Review of the Evidence

Potential of Melatonin as Adjuvant Therapy of Oral Cancer in the Era of Epigenomics

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