Biomimetic nanoplasmonic sensor for rapid evaluation of neutralizing SARS-CoV-2 monoclonal antibodies as antiviral therapy

Batool, Razia; Soler, María; Colavita, Francesca; Fabeni, Lavinia; Matusali, Giulia; Lechuga, Laura M.

doi:10.1016/j.bios.2023.115137

Cited by 11 publications

(5 citation statements)

References 60 publications

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“…The smartphone detection of the emitted light showed the high sensitivity of the developed sensor that enabled analysis of E. coli O157:H7 with a detection limit of 4.0 CFU mL −1 . Such sensors and other developed smart sensors [50][51][52][53][54][55][56] proved the ability to miniaturize analytical biodevices to be employed for POC testing of various pathogens for early diagnosis of infectious diseases. Different medical companies have already started commercialization of such nanobiodevices and developed them to be used all over the world, especially in case of a pandemic.…”

Section: Nanosensors As Poc Diagnosticsmentioning

confidence: 99%

Advances in miniaturized nanosensing platforms for analysis of pathogenic bacteria and viruses

Zeid,

Mostafa,

Lou

et al. 2023

Lab Chip

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Section: Nanosensors As Poc Diagnosticsmentioning

confidence: 99%

Advances in miniaturized nanosensing platforms for analysis of pathogenic bacteria and viruses

Zeid,

Mostafa,

Lou

et al. 2023

Lab Chip

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“…However, considering that neutralization assays are powerful tools used for COVID-19 diagnosis and the monitoring of vaccine-mediated protection, innovative strategies have emerged aiming to detect and measure accurately the neutralizing potential of antibodies against SARS-CoV-2. Currently, besides the methods mentioned above, different strategies, such as the lateral flow immunoassay (LFIA), ELISA, and surface plasmon resonance have been used to detect SARS-CoV-2 NAbs [ 67 , 68 , 69 , 70 , 71 , 72 ].…”

Section: Innovative Strategies For the Detection And Quantification O...mentioning

confidence: 99%

“…The authors showed the main advantages and limitations of each method [27,29] This work applied PRNT to measure the beneficial effect of convalescent plasma treatment of critically ill patients. They used PRNT to determine viral neutralization [28] Safety and immunogenicity studies of COVID-19 vaccines which were subjected to the PRNT assay [30][31][32][33][34][35] Works that applied pVNT 2 to measure NAbs 3 , including those in which the immunogenicity of COVID-19 vaccines was evaluated [32,38,[43][44][45][46][47][48][49][50][51][52][53][54][55][56]73] Works that applied FRNT 4 , including clinical trials [4,32,48,53,58,59] sVNT 5 reported, including a randomized clinical trial [33,49,62] SARS-CoV-2 neutralization assays based on LFIA 6 [72] SARS-CoV-2 neutralization assays based on SPR 7 [69,70] SARS-CoV-2 neutralization assays based on MIA 8 [71,74] Nanotechnology-based neutralization assays [41,68,…”

Section: Main Articles Reported Referencesmentioning

confidence: 99%

An Overview of the Conventional and Novel Methods Employed for SARS-CoV-2 Neutralizing Antibody Measurement

Rocha

Quadros

Fernandes

et al. 2023

Viruses

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SARS-CoV-2 is the etiological agent of the coronavirus disease-19 (COVID-19) and is responsible for the pandemic that started in 2020. The virus enters the host cell through the interaction of its spike glycoprotein with the angiotensin converting enzyme-2 (ACE2) on the host cell’s surface. Antibodies present an important role during the infection and pathogenesis due to many reasons, including the neutralization of viruses by binding to different spike epitopes. Therefore, measuring the neutralizing antibody titers in the whole population is important for COVID-19’s epidemiology. Different methods are described in the literature, and some have been used to validate the main vaccines used worldwide. In this review, we discuss the main methods used to quantify neutralizing antibody titers, their advantages and limitations, as well as new approaches to determineACE2/spike blockage by antibodies.

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“…They are composed of immobilized sensitive materials as recognition elements, appropriate physicochemical transducers, and signal amplification devices. The recognition elements include enzymes, antibodies, antigens, micro-organisms, cells, nucleic acids, and metabolites [ 2 , 3 , 4 , 5 , 6 , 7 ]. The physicochemical transducers include electrodes, photoelectric converters, field-effect transistors, and piezoelectric crystals [ 8 , 9 , 10 , 11 , 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Applications of Transistor-Based Biochemical Sensors

Gao

Ming

2023

Biosensors

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Transistor-based biochemical sensors feature easy integration with electronic circuits and non-invasive real-time detection. They have been widely used in intelligent wearable devices, electronic skins, and biological analyses and have shown broad application prospects in intelligent medical detection. Field-effect transistor (FET) sensors have high sensitivity, reasonable specificity, rapid response, and portability and provide unique signal amplification during biochemical detection. Organic field-effect transistor (OFET) sensors are lightweight, flexible, foldable, and biocompatible with wearable devices. Organic electrochemical transistor (OECT) sensors convert biological signals in body fluids into electrical signals for artificial intelligence analysis. In addition to biochemical markers in body fluids, electrophysiology indicators such as electrocardiogram (ECG) signals and body temperature can also cause changes in the current or voltage of transistor-based biochemical sensors. When modified with sensitive substances, sensors can detect specific analytes, improve sensitivity, broaden the detection range, and reduce the limit of detection (LoD). In this review, we introduce three kinds of transistor-based biochemical sensors: FET, OFET, and OECT. We also discuss the fabrication processes for transistor sources, drains, and gates. Furthermore, we demonstrated three sensor types for body fluid biomarkers, electrophysiology signals, and development trends. Transistor-based biochemical sensors exhibit excellent potential in multi-mode intelligent analysis and are good candidates for the next generation of intelligent point-of-care testing (iPOCT).

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Biomimetic nanoplasmonic sensor for rapid evaluation of neutralizing SARS-CoV-2 monoclonal antibodies as antiviral therapy

Cited by 11 publications

References 60 publications

Advances in miniaturized nanosensing platforms for analysis of pathogenic bacteria and viruses

Advances in miniaturized nanosensing platforms for analysis of pathogenic bacteria and viruses

An Overview of the Conventional and Novel Methods Employed for SARS-CoV-2 Neutralizing Antibody Measurement

Applications of Transistor-Based Biochemical Sensors

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