Blood Viscosity and Hematocrit as Risk Factors for Type 2 Diabetes Mellitus: The Atherosclerosis Risk in Communities (ARIC) Study

Tamariz, Leonardo; Young, J. Hunter; Pankow, James S.; Yeh, Hsin-Chieh; Schmidt, María Inês; Astor, Brad C.; Brancati, Frederick L.

doi:10.1093/aje/kwn243

Cited by 183 publications

(158 citation statements)

References 73 publications

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“…Notably, our data suggest that, even within the normal glucose tolerance category, individuals having 1-h post-challenge plasma glucose [155 mg/dl exhibit an increase in whole blood viscosity comparable with that observed in subjects with IGT. Significant associations of selected hemorheological parameters, mainly hematocrit, with future type 2 diabetes have been observed in previous clinical studies [21][22][23][24][25]. Elevated blood viscosity has been also observed in subjects with high-normal fasting glucose and IFG [6,27].…”

Section: Discussionmentioning

confidence: 74%

“…1-h plasma glucose levels have been found to be predictive of the risk of myocardial infarction and coronary heart disease [44] in subjects affected by type 2 diabetes and total mortality in nondiabetic population [45]. Elevated blood viscosity may represent one of the physio-pathologic mechanisms underlying the link of 1-h hyperglycemia to both type 2 diabetes [20][21][22][23][24][25][28][29][30] and cardiovascular diseases [7-15, 35-37, 44, 45]. Since IGT and IFG have already been recognised as dysglycemic conditions which require specific attention to halt the progression toward type 2 diabetes and decrease the associated cardiovascular risk, employing the 1-h OGTT plasma glucose criterion to screen NGT individuals may be useful to identify a subgroup that would otherwise be regarded as normal who may benefit from life style modifications and/or pharmacologic intervention in order to avoid or slow adverse clinical outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, several crosssectional studies have shown a connection between increased blood viscosity, impaired insulin sensitivity, and type 2 diabetes [16][17][18][19][20]. More importantly, longitudinal studies have demonstrated that hematocrit, a crucial parameter of blood viscosity, and blood viscosity itself are associated with incident type 2 diabetes [21][22][23][24][25]. These evidences suggest that elevated blood viscosity may occur early in the natural history of type 2 diabetes, but only limited data are available, since the studies carried out on subjects with normal glucose tolerance (NGT) or impaired glucose homeostasis were of small size or employed suboptimal definitions of dysglycemic states such as impaired glucose tolerance (IGT) [6,26,27].…”

Section: Introductionmentioning

confidence: 99%

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Elevated 1-h post-challenge plasma glucose levels in subjects with normal glucose tolerance or impaired glucose tolerance are associated with whole blood viscosity

et al. 2017

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Aim It has been suggested that glucose levels C155 mg/dl at 1-h during an oral glucose tolerance test (OGTT) may predict development of type 2 diabetes and cardiovascular events among adults with normal glucose tolerance (NGT 1 h-high). Studies showed a link between increased blood viscosity and type 2 diabetes. However, whether blood viscosity is associated with dysglycemic conditions such as NGT 1 h-high, impaired glucose tolerance (IGT) or impaired fasting glucose (IFG) is unsettled. Methods 1723 non-diabetic adults underwent biochemical evaluation and OGTT. A validated formula based on hematocrit and total plasma proteins was employed to estimate whole blood viscosity. Subjects were categorized into NGT with 1 h glucose \155 mg/dL (NGT-1 h-low), NGT-1 h-high, IFG and/or IGT. Results Hematocrit and blood viscosity values appeared significantly higher in individuals with NGT 1 h-high, IFG and/or IGT as compared to NGT 1 h-low subjects. Blood viscosity was significantly correlated with age, waist circumference, blood pressure, HbA1c, fasting, 1-and 2-h post-challenge insulin levels, total cholesterol and lowdensity lipoprotein, triglycerides, fibrinogen, white blood cell, and inversely correlated with high-density lipoprotein and insulin sensitivity. Of the four glycemic parameters, 1-h post-challenge glucose showed the strongest correlation with blood viscosity (b = 0.158, P \ 0.0001) in a multivariate regression analysis model including several atherosclerosis risk factors. Conclusions Our results demonstrate a positive relationship between blood viscosity and 1-h post-challenge plasma glucose. They also suggest that a subgroup of NGT individuals with 1-h post-challenge plasma [155 mg/dl have increased blood viscosity comparable to that observed in subjects with IFG and/or IGT.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Elevated 1-h post-challenge plasma glucose levels in subjects with normal glucose tolerance or impaired glucose tolerance are associated with whole blood viscosity

et al. 2017

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“…Одним из наиболее значимых показате-лей состояния данной системы является функцио-нальная активность тромбоцитов [3]. Кроме того, доказано прямое и косвенное участие гемореологи-ческих факторов в развитии микрососудистых и ате-росклеротических осложнений СД [4,5]. При дан-ной патологии повышается агрегация эритроцитов и вязкость крови, снижается способность мембраны эритроцитов к деформации, увеличивается адгезия эритроцитов к эндотелиальным клеткам.…”

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The influence of the new hypoglycemic agent Limiglidol on the parameters of hemostasis in experimental diabetes mellitus

Kucherenko

Спасов

Науменко

2015

Probl Endokrinol (Mosk)

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Platelet aggregation was assessed by the method of G. Born modified as described by Z.A. Gabbasov. Blood viscosity was measured using an AKR-2 rotating-type viscometer - rheological blood analyzer at six shear rates (10 s-1, 20 s-1, 50 s-1, 100 s-1, 200 s-1, and 300 s-1) simulating different intensities of the blood flow through the vessels. The model of arterial thrombosis induced by electrical current was constructed based on the method of G. Guglielmi et al (1991). Gliclazide was used in the studies of Limiglidol antiaggregant and antithrombotic properties and pentoxifylline in the studies of the influence of Limiglidol on rheological blood properties. It was shown that Limiglidol inhibited platelet aggregation and prolonged the time of thrombus formation. It proved to be superior to gliclazide in terms of these activities and reduced blood viscosity to a higher degree than pentoxifylline.

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“…Elevated whole blood viscosity was found in patients with borderline essential hypertension (Letcher et al 1983), diabetes (Tamariz et al 2008) and in patients with silent cerebral infarction (Li et al 2013). The determination of non-Newtonian whole blood viscosity could as well provide valuable information for improving perfusion management of cardiopulmonary bypass operation (Holsworth et al 2013).…”

mentioning

confidence: 99%

The new low shear viscosimeter LS300 for determination of viscosities of Newtonian and non-Newtonian fluids

Ruef

Gehm²,

Gehm³

et al. 2014

gpb

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Abstract. The low shear viscometer LS300 permits measurements of viscosity with the same precision of the LS30 but is now fully controlled by the windows based software. That allows to determine viscosity at several shear rates and to establish flow curves enabling determination of the viscosity of non-Newtonian fluids. The viscosity of whole blood of ten adults was determined via flow curves approximated by Casson. The sensitivity of the LS300 was evaluated by determining the viscosity of water at rising temperatures and by establishing flow curves of ten specimen of the same blood sample. The low shear viscosimeters LS30/LS40 and with its latest development, the LS300 is sought-after in mineral oil industry, the cosmetic and food industry and in hemorheology, too. The technique of these devices based on the Couette principle ( Fig. 1) was described as golden standard technique (Pop et al. 2004) and most useful (Ernst et al. 1985) for determination of blood viscosity at single shear rates for the preceding models of the LS300. The new LS300 (KSPV-4, Rheomed GmbH, Aachen, Germany) is now fully controlled by the LS300 software and enables the operator to establish flow curves. Shear rate and viscosity are directly related to the properties of the fluid. Non-Newtonian fluids are governed by a non-linear relationship between shear stress and shear rate, whereas the viscosity of Newtonian fluids is independent from shear rate (Fig. 2), as indicated by the linear relation between shear rate and shear stress (Papaioannou et al. 2005). These flow curves can be approximated by mathematical models, which allow calculating the viscosity of a non-Newtonian fluid like whole blood (Shi et al. 1996;Baskurt et al. 2003;Marcinkowska-Gapinska et al. 2007).The LS300 (proRheo GmbH, Althengstett, Germany) is a rotational rheometer based on the Couette principle ( Fig. 1), equipped with a rotating measuring cup and a fixed measuring element. Thus, the measurements are not influenced by the Taylor vortex. The measuring principle is the same as the LS30 previously described (Aarts et al. 1984). The material number of the cup and the bob is steel (EN 1.4571).The radius of the measuring cup is 6 mm, the radius of the bob is 5.5 mm and the length of the bob is 8 mm. The sample volume was 0.9 ml. The bob was always covered with the tested sample. The software LS300 regulates the rotation count of the measuring cup. The number of measuring points at several shear rates and time may be selected as desired. The thermostat of the LS300 works with cryoregulation; its accuracy is ±0.1°C. The new technology of LS300 permits determination of shear forces at multiple shear rates during a single measuring run, over a wide range of shear rates from 0.018 to 125 s −1 (in steps of 0.01 s −1 ). By graphic presentation of shear rate versus shear stress one obtains data points which, when connected to each other, yield a flow curve (Fig. 3). The viscosity of non-Newtonian fluids can be determined by approximation of these flow curves with mathematical mo...

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Blood Viscosity and Hematocrit as Risk Factors for Type 2 Diabetes Mellitus: The Atherosclerosis Risk in Communities (ARIC) Study

Cited by 183 publications

References 73 publications

Elevated 1-h post-challenge plasma glucose levels in subjects with normal glucose tolerance or impaired glucose tolerance are associated with whole blood viscosity

Elevated 1-h post-challenge plasma glucose levels in subjects with normal glucose tolerance or impaired glucose tolerance are associated with whole blood viscosity

The influence of the new hypoglycemic agent Limiglidol on the parameters of hemostasis in experimental diabetes mellitus

The new low shear viscosimeter LS300 for determination of viscosities of Newtonian and non-Newtonian fluids

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Blood Viscosity and Hematocrit as Risk Factors for Type 2 Diabetes Mellitus: The Atherosclerosis Risk in Communities (ARIC) Study

Cited by 183 publications

References 73 publications

Elevated 1-h post-challenge plasma glucose levels in subjects with normal glucose tolerance or impaired glucose tolerance are associated with whole blood viscosity

Elevated 1-h post-challenge plasma glucose levels in subjects with normal glucose tolerance or impaired glucose tolerance are associated with whole blood viscosity

The influence of the new hypoglycemic agent Limiglidol on the parameters of hemostasis in experimental diabetes mellitus

The new low shear viscosimeter LS300 for determination of viscosities of Newtonian and non-Newtonian fluids

Contact Info

Product

Resources

About

The new low shear viscosimeter LS300 for determination of viscosities of Newtonian and non-Newtonian fluids