Brain perfusion differences between Parkinson's disease and multiple system atrophy with predominant parkinsonian features

A review of orthostatic blood pressure regulation and its association with mood and cognition

“…Comparing brain perfusion among PD patients with or without OH showed that bilateral activity in the anterior cingulate gyrus played a role in autonomic failure. The anterior cingulate gyrus was significantly less perfused in the participants with OH [26]. It is generally accepted that reduced CBF may account for the increased prevalence of OH among patients with dementia.…”

“…The autonomic nervous system is controlled by the hypothalamus, which in turn is controlled by limbic structures including the cingulate gyrus. The degeneration of the anterior cingulate gyrus provokes hypothalamic dysfunction, which projects to various cortical and subcortical structures contributing to autonomic effects evident in various disorders [26]. Current literature on brain perfusion and cognitive performance indicates that in individuals with chronic hypotension, BP is inadequate at maintaining perfusion of a large part of the brain despite autoregulation [25].…”

Usefulness of rCBF analysis in diagnosing Parkinson’s disease: supplemental role with MIBG myocardial scintigraphy

“…The results of the present study using 3D-SRT analysis agreed with the earlier report. In addition, recent studies showed that both hypometabolism and hypoperfusion of the occipital lobe are the characteristics of PD [22][23][24]. Arahata et al [22,36] reported that PD with autonomic nerve disturbance represents occipital lobe hypoperfusion.…”

“…PD with autonomic nerve impairment showed hypometabolism in the parieto-occiptal lobe [22][23][24]. Bohnen et al [20] reported a correlation between glucose metabolism and the severity of motor impairment.…”

Recent developments in multiple system atrophy

“…Finally, brain perfusion SPECT shows striatal hypoperfusion in MSA-P that distinguishes this disorder from PD [20,36,105,183]. Perfusion SPECT, when coupled with classic MRI, shows high sensitivity and specificity in differentiating MSA from PD [36].…”