Breast Cancer Cells Isolated by Chemotaxis from Primary Tumors Show Increased Survival and Resistance to Chemotherapy

Goswami, Sumanta; Wang, Weigang; Wyckoff, Jeffrey; Condeelis, John S.

doi:10.1158/0008-5472.can-04-2027

Cited by 59 publications

(59 citation statements)

References 13 publications

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“…Thus, Snail confers a selective advantage to embryonic cells migrating towards their final destination and to invasive malignant cells in their attempts to disseminate and form metastasis. Again, the in vivo purification of disseminating cells has confirmed that these cells are resistant to conventional chemotherapy (Goswami et al, 2004).…”

Section: Old Views and New Perspectivesmentioning

confidence: 98%

Epithelial-Mesenchymal Transitions in development and disease: old views and new perspectives

Nieto¹

2009

Int. J. Dev. Biol.

211

157

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The epithelial to mesenchymal transition (EMT) is a fascinating phenotypic change that is undertaken by embryonic and adult cells in physiological and pathological conditions, respectively. This change in cell behavior involves the loss of epithelial characteristics and the acquisition of migratory properties. While it has long been established as a fundamental process in the generation of many different embryonic tissues, its significance during tumor progression as an initial determining step in the metastatic cascade has remained a matter of debate. Recent molecular analyses coupled with state-of-the-art imaging technology have helped to define the EMT as an important landmark, not only during tumor progression, but also during the development of other pathologies such as organ fibrosis. Spanish groups have contributed to the analysis of EMT both from the developmental and the pathological point of view, in particular assessing the implication of the Snail genes in this process. Interestingly, the contribution of Spanish scientists to the existence of EMT in tumors possibly goes back more than 100 years, when Cajal referred to some "pear-like cells, not attached to each other" in his description of human breast carcinomas.

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Section: Old Views and New Perspectivesmentioning

confidence: 98%

Epithelial-Mesenchymal Transitions in development and disease: old views and new perspectives

Nieto¹

2009

Int. J. Dev. Biol.

211

157

View full text Add to dashboard Cite

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“…It also induces resistance to apoptosis induced by various stimuli, genotoxic stress and loss of growth factors (Kajita et al, 2004;Vega et al, 2004;Perez-Losada et al, 2005). The latter property is shared by purified disseminating cancer cells (Goswami et al, 2004). …”

Section: Cells In Emt Little Proliferatementioning

confidence: 99%

Cancer cells in epithelial-to-mesenchymal transition and tumor-propagating–cancer stem cells: distinct, overlapping or same populations

Floor¹,

Staveren²,

et al. 2011

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“…MTLn3 cells have shown resistance to available chemotherapy drugs (Goswami et al 2004). The over expression of epidermal growth factor (EGF) receptor make them highly sensitive to chemoattractant (i.e.…”

Section: Effects Of Hormesis Induced By Arsenic Trioxidementioning

confidence: 99%

Dose Response of MTLN3 Cells to Serial Dilutions of Arsenic Trioxide and Ionizing Radiation

et al. 2011

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ᮀ MTLn3 cells derived from mouse mammary epithelium are known to be highly malignant and are resistant to both radio-and chemo-therapy. We exposed MTLn3 cells to various doses of inorganic Arsenic trioxide (As 2 O 3 ) in combination with ionizing radiation. Cells were treated with a series of As 2 O 3 concentrations ranging from 20 µM to 1.22 nM for 8 hour, 24 hour and 48 hour periods. Post-treated cell proliferation was quantified by measuring mitochondrial activity and DNA analysis. Cells exposed to radiation and As 2 O 3 at concentration greater than 1.25 µM showed apoptosis and radiations alone treated cells were statistically not different from the control. Hormesis was observed for As 2 O 3 concentrations in the range of 0.078 µM to 0.625 µM while the combined chemo and radiation treatments of the cells did not affect the hormetic effect. We have demonstrated that As 2 O 3 (in the presence and absence of ionizing radiation) in specific low concentrations induced apoptosis in the otherwise chemoresistant cancer cells. This low concentrationmediated cell death is immediately followed by a surge in cell survival. Low dosing dosimetry is highly desirable in metronomic therapy however, it has a narrow window since necrosis, hormesis, apoptosis and other dose-dependent biological processes take place in this region. Further quantifiable dosimetry is highly desired for routine clinical practice.

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Breast Cancer Cells Isolated by Chemotaxis from Primary Tumors Show Increased Survival and Resistance to Chemotherapy

Cited by 59 publications

References 13 publications

Epithelial-Mesenchymal Transitions in development and disease: old views and new perspectives

Epithelial-Mesenchymal Transitions in development and disease: old views and new perspectives

Cancer cells in epithelial-to-mesenchymal transition and tumor-propagating–cancer stem cells: distinct, overlapping or same populations

Dose Response of MTLN3 Cells to Serial Dilutions of Arsenic Trioxide and Ionizing Radiation

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