Calcitonin: A non-invasive giant cells therapy

Glucocorticoid and calcitonin receptor expression in central giant cell lesions: implications for therapy

“…8 Amongst these strategies is the use of systemic calcitonin [15][16][17]25 and intralesional injections with corticosteroids. [18][19][20][21]24 Both of these strategies are increasingly being used and have shown promising results.…”

“…1 Traditionally, surgery is the treatment of choice for CGCLs, and the extent of surgery ranges from curettage with or without adjuvant therapy, such as cryosurgery, peripheral ostectomy and carnoy solution, to aggressive en bloc resection, 12,13 resulting in varying degrees of deformity. 11 Non-surgical methods have been proposed to treat CGCLs, including radiotherapy, 14 systemic calcitonin, [15][16][17] intralesional injection with corticosteroids and systemic a interferon. 22,23 In an earlier report, 24 the authors presented excellent results with intralesional triamcinolone with a good response in 15/ 21 patients, a moderate response in 4/21 patients and a negative response in 2/21 patients.…”

Can calcitonin nasal spray reduce the risk of recurrence of central giant cell granuloma of the jaws? A double-blind clinical trial

“…In jaw lesions, calcitonin inhibits their growth via the effects mediated by the calcitonin receptor (CTR). 11 Giant cells have been shown to express osteoclastic markers, such as tartrate-resistant acid phosphatase (TRAP), vitronectin, and CTR, and can resorb lacunar bone in vitro. 13 Aggressive CGCGs have higher CTR expression.…”

“…10 In studies reported in the literature, calcitonin has been applied for the treatment of CGCGs either alone or as an adjunct agent. 11 However, it has not been used to prevent recurrence in the management of CGCGs. Thus, this study was performed to assess the use of calcitonin after curettage of aggressive CGCGs to determine whether it reduces the frequency of recurrence or not.…”

Fine Needle Aspiration Cytology and Intralesional Steroid Injection in a Central Giant Cell Granuloma Affecting the Gingiva: A New Clinical Approach

“…In the last years, different nonsurgical treatments have been proposed. Systemic calcitonin, interferon 2-alpha and intralesional corticosteroids have shown varying degrees of success and reduced the necessity of major surgical procedures (9,14,15). The use of steroids for treating CGCGs was first suggested in 1981; however, their systemic administration had to be stopped because of important side effects (16).…”