Calcium-induced vasocontractions after alpha-2 adrenergic receptor activation in the dog saphenous vein: Comparison to calcium-induced contractions after potassium-depolarization

Lee, J.Y.; Warner, Robert B.; Brune, Michael E.; DeBernardis, John F.

doi:10.1016/0306-3623(90)91012-g

Cited by 7 publications

(1 citation statement)

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“…In humans, α2CR is mainly responsible for venous constriction, and α2AR is responsible for arterial constriction [ 32 ], consistent with our findings in goats. However, in dogs, α2AR is mainly detected in veins [ 33 ]. The myocardium of goats expressed mainly α2BR and α2CR in our study; however, Regitz-Zagrosek reported that the human myocardium mainly expresses α2CR [ 34 ] and that mice mainly express α2AR [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

The Characteristics and Distribution of α2D-, α2B- and α2C-Adrenoceptor Subtypes in Goats

Zhang

Wang

et al. 2022

Animals

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α2-Adrenegic receptors (α2Rs) are important presynaptic modulators of central noradrenergic function (auto receptors) and postsynaptic mediators of many of the widespread effects of catecholamines and related drugs. Studies have shown that ruminants (such as goats and cattle) express special α2DR subtypes in addition to α2BR and α2CR. Real-time quantitative PCR and Western blotting were used to investigate the distribution and density of α2R in different nuclei of the goat central nervous system, selected regions of the spinal cord (L4-L6), and in various peripheral tissues. α2-AR subtype-specific antibodies were injected intrathecally and intracerebroventricularly into the tested goats to block the corresponding subtype of receptors. Pain threshold and physiological parameters were evaluated to explore the functional characteristics of α2BR, α2CR and α2DR in goats. Our results suggest that the expression of the mRNAs and proteins of all three α2R subtypes are widely but unevenly distributed in the goat CNS and peripheral tissues. Furthermore, α2DR plays a more important role in α2R-mediated analgesia in goats than α2BR and α2CR, whereas α2CR activation exerts a greater effect on body temperature than α2BR and α2DR.

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