Calcium Phosphate Nanocoatings and Nanocomposites, Part 2: Thin Films for Slow Drug Delivery and Osteomyelitis

Abstract

During the last two decades although many calcium phosphate based nanomaterials have been proposed for both drug delivery, and bone regeneration, their coating applications have been somehow slow due to the problems related to their complicated synthesis methods. In order to control the efficiency of local drug delivery of a biomaterial the critical pore sizes as well as good control of the chemical composition is pertinent. A variety of calcium phosphate based nanocoated composite drug delivery systems are currently being investigated. This review aims to give an update into the advancements of calcium phosphate nanocoatings and thin film nanolaminates. In particular recent research on PLA/hydroxyapatite composite thin films and coatings into the slow drug delivery for the possible treatment of osteomyelitis is covered.

Biocompatibility of a new biodegradable polymer-hydroxyapatite composite for biomedical applications

“…Hydrothermally converted coralline hydroxyapatite particles were loaded with 10% w/w of gentamicin as described in previous works [7,11]. The required amount of gentamicin was dissolved in polished 18 MU water (MilliQ, Millipore, Victoria, Australia), mixed with HAp, sonicated and then dried using a Rotavapor R 210 coupled with a V 850, BUCHI (In vitro Technologies, Australia, vacuum controller) at 60 C. Gentamicin loaded cHAp micro spheres were then dried in vacuumed desiccators and used to produce PLA thin film composites.…”

Development of antimicrobial composite coatings for drug release in dental, orthopaedic and neural prostheses applications

“…For this reason, antibiotic-containing PLA/hydroxyapatite ceramic thin-film biocomposites as coating materials have been developed in order to improve the surface properties of the implants, to prevent implant-related infections, and also to provide treatments for various postoperation complications, such as osteomyelitis [15].…”

Antibiotic Containing Poly Lactic Acid/Hydroxyapatite Biocomposite Coatings for Dental Implant Applications

“…In this research microspheres of coral were converted into HAp using hydrothermal technique and incorporated within biodegradable thin poly-lactic acid (PLA) to form thin film composites. Treatment of the coral and the conversion methods were covered in our previous publications [8].…”

“…The drug loading and composites preparation were illustrated in Fig. 1 [8]. This method allows us to preserve the nano and meso-porous structure as appropriate drug carrier systems for sustained release of antibiotics (gentamicin (GM)) on titanium dental implants.…”