Calcium Phosphate Scaffold Loaded with Platinum Nanoparticles for Bone Allograft

Eid, Kamel; Eldesouky, Amal Samir; Fahmy, Ali; Shahat, Ahmed; AbdElaal, Reda

doi:10.5099/aj130400242

Cited by 16 publications

(6 citation statements)

References 26 publications

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“…Additionally, they protect cells from oxidation-induced inflammation which inhibits pulmonary inflammation and induced bone loss by decreasing osteoclastogenesis. PtNPs also assisted cell growth and could promote cell proliferation [96]. • Silver-Silver (Ag) is a well-known material already used in coatings for biomedical devices and in wound care products thanks to its antibacterial properties.…”

mentioning

confidence: 99%

A Review on Biomaterials for 3D Conductive Scaffolds for Stimulating and Monitoring Cellular Activities

et al. 2019

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During the last years, scientific research in biotechnology has been reporting a considerable boost forward due to many advances marked in different technological areas. Researchers working in the field of regenerative medicine, mechanobiology and pharmacology have been constantly looking for non-invasive methods able to track tissue development, monitor biological processes and check effectiveness in treatments. The possibility to control cell cultures and quantify their products represents indeed one of the most promising and exciting hurdles. In this perspective, the use of conductive materials able to map cell activity in a three-dimensional environment represents the most interesting approach. The greatest potential of this strategy relies on the possibility to correlate measurable changes in electrical parameters with specific cell cycle events, without affecting their maturation process and considering a physiological-like setting. Up to now, several conductive materials has been identified and validated as possible solutions in scaffold development, but still few works have stressed the possibility to use conductive scaffolds for non-invasive electrical cell monitoring. In this picture, the main objective of this review was to define the state-of-the-art concerning conductive biomaterials to provide researchers with practical guidelines for developing specific applications addressing cell growth and differentiation monitoring. Therefore, a comprehensive review of all the available conductive biomaterials (polymers, carbon-based, and metals) was given in terms of their main electric characteristics and range of applications.

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confidence: 99%

A Review on Biomaterials for 3D Conductive Scaffolds for Stimulating and Monitoring Cellular Activities

et al. 2019

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“…The casted slurry was initially dried at 100 • C for 24 h followed by sintering at 400 • C. Superior porosity between 30-35% with pore sizes between 100 to 400 µm was found in the scaffolds designed with 20 wt% CPs. The scaffolds were biodegradable and 10% PtNPs significantly enhanced cell attachment and proliferation on the scaffold surface [65].…”

Section: Platinum and Palladiummentioning

confidence: 99%

“…These nanoparticles are known to ameliorate oxidative stress by scavenging reactive oxygen species (ROS) which is critical to prevent several diseases [62][63][64]. Hence, these medically significant nanoparticles can protect one from neurodegenerative disorders, such as Alzheimer's disease, and also protect cells from oxidation-induced inflammation and induced bone loss by decreasing osteoclastogenesis [65]. However, less work has been done towards the incorporation of PtNPs and PdNPs for bone tissue regeneration.…”

Section: Platinum and Palladiummentioning

confidence: 99%

Metallic Nanoscaffolds as Osteogenic Promoters: Advances, Challenges and Scope

Ghosh

Webster

2021

Metals

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Bone injuries and fractures are often associated with post-surgical failures, extended healing times, infection, a lack of return to a normal active lifestyle, and corrosion associated allergies. In this regard, this review presents a comprehensive report on advances in nanotechnology driven solutions for bone tissue engineering. The fabrication of metals such as copper, gold, platinum, palladium, silver, strontium, titanium, zinc oxide, and magnetic nanoparticles with tunable physico-chemical and opto-electronic properties for osteogenic scaffolds is discussed here in detail. Furthermore, the rational selection of a polymeric base such as chitosan, collagen, poly (L-lactide), hydroxyl-propyl-methyl cellulose, poly-lactic-co-glycolic acid, polyglucose-sorbitol-carboxymethy ether, polycaprolactone, natural rubber latex, and silk fibroin for scaffold preparation is also discussed. These advanced materials and fabrication strategies not only provide for appropriate mechanical strength but also render integrity, making them appealing for orthopedic applications. Further, such scaffolds can be functionalized with ligands or biomolecules such as hydroxyapatite, polypyrrole (PPy), magnesium, zinc dopants, and growth factors to stimulate osteogenic differentiation, mineralization, and neovascularization to aid in rapid healing. Future directions to co-incorporate bioceramics, biogenic nanoparticles, and fourth generation biomaterials to enhance biocompatibility, mechanical properties, and rapid recovery are also included in this review. Hence, the further development of such biomimetic metal-based nano-scaffolds at a lower cost with reduced risks and greater efficacy at regrowing bone can revolutionize the future of orthopedics.

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“…The effect of Pt NPs alone has also been reported in the study conducted by Eid et al Pt NPs were loaded into calcium phosphate scaffold for bone allograft. There was enhanced cell proliferation and attachment [31]. Nevertheless, the number of studies on the applications of Pt NPs in tissue engineering is highly limited compared to Au and Ag NPs.…”

Section: Noble Metal Nps Hydrogel and Np–hydrogel Compositementioning

confidence: 99%

Application of Metal Nanoparticle–Hydrogel Composites in Tissue Regeneration

2019

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Challenges in organ transplantation such as high organ demand and biocompatibility issues have led scientists in the field of tissue engineering and regenerative medicine to work on the use of scaffolds as an alternative to transplantation. Among different types of scaffolds, polymeric hydrogel scaffolds have received considerable attention because of their biocompatibility and structural similarity to native tissues. However, hydrogel scaffolds have several limitations, such as weak mechanical property and a lack of bioactive property. On the other hand, noble metal particles, particularly gold (Au) and silver (Ag) nanoparticles (NPs), can be incorporated into the hydrogel matrix to form NP–hydrogel composite scaffolds with enhanced physical and biological properties. This review aims to highlight the potential of these hybrid materials in tissue engineering applications. Additionally, the main approaches that have been used for the synthesis of NP–hydrogel composites and the possible limitations and challenges associated with the application of these materials are discussed.

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Calcium Phosphate Scaffold Loaded with Platinum Nanoparticles for Bone Allograft

Cited by 16 publications

References 26 publications

A Review on Biomaterials for 3D Conductive Scaffolds for Stimulating and Monitoring Cellular Activities

A Review on Biomaterials for 3D Conductive Scaffolds for Stimulating and Monitoring Cellular Activities

Metallic Nanoscaffolds as Osteogenic Promoters: Advances, Challenges and Scope

Application of Metal Nanoparticle–Hydrogel Composites in Tissue Regeneration

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