Can photobiomodulation therapy (PBMT) control blood glucose levels and alter muscle glycogen synthesis?

Castro, Kênia Mendes Rodrigues; Carvalho, Rodrigo Leal de Paiva; Rosa, Geraldo Marco; Tavares, Beatriz Antoniassi; Simionato, Luis Henrique; Bortoluci, Carlos Henrique Fachin; Soto, Claudio A. Telléz; Ferraresi, Cleber

doi:10.1016/j.jphotobiol.2020.111877

Cited by 18 publications

(13 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They assessed fasting plasma glucose and muscle glycogen concentration in non-diabetic rats. Thus the authors found that the energy density of 10 J/cm 2 applied on the back, posterior limbs, and gluteus maximus muscles for 90 s induced lower fasting plasma glucose levels and higher muscle glycogen synthesis after PBM [15].…”

Section: Metabolic Responsesmentioning

confidence: 95%

“…The possible mechanisms of action are related to the regulation of cytochrome c oxidase (Cox) activity as photoreceptors and the muscle glycogen synthesis [8,15,35,36]. PBM is known to modulate mitochondrial function, increasing muscle cell adenosine triphosphate (ATP) synthesis [35][36][37], possible phosphocreatine resynthesis, and reducing acidification by accelerating the oxidation of lactate to pyruvate through the mitochondrial metabolism [38].…”

Section: Metabolic Responsesmentioning

confidence: 99%

“…Moreover, concerning the mechanisms of action of the PBM, an animal model study observed that PBM increases the activity of citrate synthase (CS), a key enzyme responsible for catalyzing the first reaction of the citric acid cycle (Krebs Cycle), which is closely related to Cox [39,40]. Thus, there appears to be an increase in the activity of the Krebs cycle after irradiation of PBM, increasing the use of glucose for the synthesis of ATP, which can contribute to increased muscle glycogen synthesis and a consequent reduction in fasting plasma glucose levels [15,40].…”

Section: Metabolic Responsesmentioning

confidence: 99%

“…As also previously showed, the effects of PBM have been widely studied in cell culture [13,14], animal models [12,[15][16][17], combining physical exercise [7,18] with muscle performance [19] and post-exercise recovery [19,20]. However, the effects of the different energies of PBM by LEDs on the cardiovascular and/or hemodynamic and metabolic systems in individuals with T2DM are still not clear, and the optimal doses have not yet been defined.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Dose Response Effect of Photobiomodulation on Hemodynamic Responses and Glucose Levels in Men with Type 2 Diabetes: A Randomized, Crossover, Double-Blind, Sham-Controlled Trial

et al. 2022

Self Cite

View full text Add to dashboard Cite

This study verifies the acute dose response effect of photobiomodulation (PBM) by light emitting diodes (LEDs) on hemodynamic and metabolic responses in individuals with type 2 diabetes mellitus (T2DM). Thirteen participants with T2DM (age 52 ± 7 years) received PBM by a light-emitting diode array (50 GaAIAs LEDs, 850 ± 20 nm, 75 mW per diode) on the rectus and oblique abdomen, quadriceps femoris, triceps surae, and hamstring muscle areas, bilaterally, using different energy treatments (sham, 75, 150, 300, 450, and 600 Joules) in random order with a washout of at least 15 days apart. The PBM by LEDs statistically decreased plasma glucose levels (primary outcome) in 15 min after application of the 75 and 450 J irradiation protocol, reduced blood lactate levels 15 min after application of the 75, 450, and 600 J irradiation protocol, increased cardiac output (Q˙) and cardiac index (CI) in the 1st minute after application of the 75 and 300 J irradiation protocol, and reduced Q˙ and heart rate (HR) in the 15 min after application of the 300 J and 600 J irradiation protocol, respectively. For hemodynamic variables, including Q˙, total peripheral resistance (TPR), and HR, we observed that the ideal therapeutic window ranged between 75 and 300 J, while for metabolic variables, glucose and lactate, the variation was between 450 and 600 J.

show abstract

Section: Metabolic Responsesmentioning

confidence: 95%

Section: Metabolic Responsesmentioning

confidence: 99%

Section: Metabolic Responsesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Dose Response Effect of Photobiomodulation on Hemodynamic Responses and Glucose Levels in Men with Type 2 Diabetes: A Randomized, Crossover, Double-Blind, Sham-Controlled Trial

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…The dose of alloxan for 160 mg/kg body weight was injected intraperitoneally to all male adult albino rats after 6 h. For the next 24 h, the rats were maintained on 5% glucose solution bottles in their cages to prevent hypoglycemia [ 11 ]. Fasting blood glucose values >7 mmol/L (126 mg/dL) were considered diabetic [ 12 ].…”

Section: Methodsmentioning

confidence: 99%

Hypoglycemic and hypolipidemic activity of combined milk thistle and fenugreek seeds in alloxan-induced diabetic albino rats

Saadh

2020

Vet World

View full text Add to dashboard Cite

Background and Aim: Despite the availability of antidiabetic drugs, they are not free from associated adverse side effects. This study aimed to evaluate the hypoglycemic and hypolipidemic effects of oral administration of seeds from two medicinal plants: (1) Milk thistle and (2) fenugreek. Materials and Methods: Plant seeds were washed in distilled water and ground with a coffee grinder. Alloxan was used to induce diabetes in 20 male albino rats. Diabetic rats were randomly divided into two groups: (1) Group 1 (n=10), diabetic rats fed with 0.5 g/kg milk thistle and 2 g/kg fenugreek seeds per day and (2) Group 2 (n=10), diabetic rats fed standard rodent food for 4 weeks. Results: Oral administration of milk thistle and fenugreek seeds for 2 weeks resulted in significant improvement in body weight, blood glucose, glycosylated hemoglobin (HbA1c), cholesterol, and triglyceride levels in alloxan-induced diabetic rats. After 4 weeks, this ameliorative effect was significantly elevated with respect to blood glucose (155.00±9.70 mg/ dL vs. 427.50±5.70 mg/dL; p<0.001), HbA1c (5.5±0.19% vs. 13.65±1.77%; p<0.001), cholesterol (281.50±10.95 mg/dL vs. 334.30±6.80 mg/dL; p<0.001), triglyceride (239.60±6.87 mg/dL vs. 284.20±9.95 mg/dL; p<0.01), and body weight (265.30±8.10 g vs. 207.40±11.4 g; p<0.01) as compared with non-treated diabetic rats. Conclusion: Milk thistle and fenugreek seeds possess hypoglycemic and hypolipidemic properties and could be used as natural compounds that are suitable as parent compounds for the development of new antidiabetic drugs.

show abstract

Dose and time–response effect of photobiomodulation therapy on glycemic control in type 2 diabetic patients combined or not with hypoglycemic medicine: A randomized, crossover, double‐blind, sham‐controlled trial

Scontri,

de Castro Magalhães,

Damiani

et al. 2023

Journal of Biophotonics

Self Cite

View full text Add to dashboard Cite

Photobiomodulation therapy (PBMt) combined or not with oral hypoglycemic medication has not been investigated in type 2 diabetes (T2DM) patients. All 10 T2DM patients were assessed randomly at 6 different occasions (3 with and 3 without regular oral hypoglycemic medication). Capillary glycemia was assessed after overnight fast (pre‐prandial), 1 h postprandially (standardized meal, 338 kcal), and 30 min, 3 h, 6 h, 12 h post‐PBMt (830 nm; 25 arrays of LEDs, 80 mW/array). Three doses (0 J—sham, 100 J, 240 J per site) were applied bilaterally on quadriceps femoris muscles, hamstrings, triceps surae, ventral upper arm and forearm; and randomly combined or not with oral hypoglicemic medication, totaling six different therapies applied for all 10 TDM2 patients (PBMt sham, PBMt 100 J, PBMt 240 J, PBMt sham + medication, PBMt 100 J + medication, PBMt 240 J + medication). Cardiac autonomic control was assessed by heart rate variability (HRV) indices. Without medication, there was reduction in glycemia after all PBMt doses, with 100 J as the best dose that persisted until 12 h and presented lower area under the curve (AUC). With medication, glycemia decreased similarly among doses. No differences between 100 J and sham + medication, but AUC was significantly lower after 100 J, suggesting better glycemic control. Low frequency component of HRV increased after sham + medication and 100 J, suggesting higher sympathetic activation. PBMt showed time– and dose–response effect to reduce glycemia in T2DM patients. Effects on HRV were consistent with glycemic control.

show abstract

Can photobiomodulation therapy (PBMT) control blood glucose levels and alter muscle glycogen synthesis?

Cited by 18 publications

References 27 publications

Dose Response Effect of Photobiomodulation on Hemodynamic Responses and Glucose Levels in Men with Type 2 Diabetes: A Randomized, Crossover, Double-Blind, Sham-Controlled Trial

Dose Response Effect of Photobiomodulation on Hemodynamic Responses and Glucose Levels in Men with Type 2 Diabetes: A Randomized, Crossover, Double-Blind, Sham-Controlled Trial

Hypoglycemic and hypolipidemic activity of combined milk thistle and fenugreek seeds in alloxan-induced diabetic albino rats

Dose and time–response effect of photobiomodulation therapy on glycemic control in type 2 diabetic patients combined or not with hypoglycemic medicine: A randomized, crossover, double‐blind, sham‐controlled trial

Contact Info

Product

Resources

About