Cancer Targeted Metallic Nanoparticle: Targeting Overview, Recent Advancement and Toxicity Concern

Abstract

The targeted delivery of theranostic agents to the cancer cells is one of the major challenges and an active field of research in the development of cancer chemotherapeutic approaches. Theranostic metallic nanoparticles (TMNPs) have garnered increasing attention in recent years as a novel tool for theranostic application such as imaging, diagnosis, and therapeutic delivery of active agents to tumour specific cells. This paper attempts to unveil the multidimensional theranostic aspects of multifunctional metallic nanoparticles (MNPs)including passive and active targeting (HER2, Folate, Angiogenesis etc.) as well as the RES escaping approach. Special attention is given to the theranostic application of MNPs in oncology. Patents issued by the US office in this nanotechnological arena are also included emphasising the importance of MNPs in current cancer treatment/imaging research scenario. Keeping in mind the blooming research in clinical application directed nanotechnology; toxicity concerns related with MNPs are. also discussed, in element.

Paclitaxel-loaded iron platinum stealth immunomicelles are potent MRI imaging agents that prevent prostate cancer growth in a PSMA-dependent manner

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Self-assembled nanoparticles based on amphiphilic chitosan derivative and arginine for oral curcumin delivery

“…Chemotherapy remains the mainstay of treatment, and most of the chemotherapeutic drugs are administered parenterally, causing severe adverse effects due to impulse concentrations in blood stream leading to poor patients' compliance and 4398 raja et al ultimately to failure of therapy. [2][3][4][5][6] Oral delivery of anticancer agents could be a feasible alternative to parenteral administration, since it can avoid fluctuation of drug concentration, minimize drug-related adverse effects, and thus improve the overall efficacy of drugs; moreover, patients are more receptive to it. [7][8][9] However, the oral delivery of anticancer agents is often associated with low bioavailability due to the first-pass effect and physical absorption barriers in gastrointestinal tract (GIT).…”

Applications of nanoparticles in cancer medicine and beyond: optical and multimodalin vivoimaging, tissue targeting and drug delivery

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