Candida albicans biofilms on different materials for manufacturing implant abutments and prostheses

Eguia, Asier; Arakistain, Ane; De-la-Pinta, Iker; López-Vicente, José; Sevillano, Elena; Quindós, Guillermo; Eraso, Elena

doi:10.4317/medoral.23157

Cited by 21 publications

(12 citation statements)

References 28 publications

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“…One of the major complications that could appear after implant related surgery and lead to the rejection of the implant is the occurrence of infection with Candida albicans fungal strain [31,32]. Therefore, in order to combat this major health problem, it is important to use implants coated with biomaterials with intrinsic antimicrobial properties [31,32] such as samarium-doped hydroxyapatite [13].…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Physico-Chemical Properties of Antifungal Samarium Doped Hydroxyapatite Thin Films

et al. 2021

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Samarium doped hydroxyapatite (Ca10−xSmx(PO4)6(OH)2, xSm = 0.5, 50SmHAp) is a very promising candidate to be used for different coatings in various dental and orthopedic implants. We report, for the first time, the obtaining of 50SmHAp thin films by a cost-effective method, namely spin coating. Thin films of 50SmHAp on silicon substrate have been analyzed by various techniques such as Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), atomic force microscopy (AFM), Metallographic microscopy and Glow Discharge Optical Emission Spectroscopy (GDOES). The stability of 50SmHAp suspension was evaluated by ultrasound measurements. Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM) and scanning electron microscopy (SEM) were also used to evaluate the 50SmHAp suspension. The antifungal activity of 50SmHAp suspension and coatings was assessed using Candida albicans ATCC 10231 fungal strain (C. albicans). The results of the antifungal assays depicted that both 50SmHAp suspensions and coatings were effective in inhibiting the development of C. albicans fungal cells, thus making them ideal candidates for the development of novel antifungal agents. The obtained results give new perspective for possible applications of 50SmHAp thin films in various medical applications due to their antifungal properties.

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Section: Introductionmentioning

confidence: 99%

Fabrication and Physico-Chemical Properties of Antifungal Samarium Doped Hydroxyapatite Thin Films

et al. 2021

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“…It has been demonstrated in in vitro conditions that the aforementioned material characteristics may determine the way biofilm is formed. Significantly greater growth of Candida was noted in PMMA-based materials compared to metal alloys [ 29 ]. In our investigation, significantly greater Candida colonization was found in subjects with PMMA-based prosthetic appliances.…”

Section: Discussionmentioning

confidence: 99%

Oral Candidal Colonization in Patients with Different Prosthetic Appliances

Devcic

Simonić-Kocijan

Prpić

et al. 2021

JoF

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Oral infections caused by Candida species are becoming more common, which may be related to an increase in the number of immunologically compromised patients as well as favorable conditions in the oral cavity that often include removable prosthetic appliances. The purpose of this study was to determine the presence of a particular Candida species in patients with PMMA and Cr-Co prosthetic appliances, as well as the salivary flow rate, and oral signs and symptoms. This investigation included a total of 120 subjects with different kinds of removable dentures. A sample of concentrated oral rinse was collected from all subjects in order to detect Candida colonization and identify the Candida species, a quantum of salivation was measured, and subjects were examined clinically. Candida spp. was predominant among the subjects who were denture wearers (p < 0.0001). In all subjects, the most frequently detected species was C.albicans. A statistically significant difference was found between the prevalence of C.albicans (p < 0.001) and C.krusei (p < 0.001) in denture wearers. Subjects with PMMA-based removable prosthetic appliances mostly demonstrated a significant decrease in salivation (p < 0.001), an increase in burning sensations (p < 0.001), and dry mouth (p < 0.001) compared to the subjects who wore partial dentures with Co–Cr metallic frameworks. Red oral lesions were more frequently found among the subjects with partial dentures with Co–Cr metallic frameworks (p < 0.001). Regardless of the material used for the denture, patients must be regularly checked by their dentists in order to prevent the development of oral lesions.

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“…Fungal biofilms can mature in 48 hours in an in vitro environment but some substances in serum and tissue fluid might encourage biofilm formation in vivo, resulting in a smaller duration for biofilms maturation (Matsumoto et al, 2021). Moreover, fungal resistance emerges in the early phases of biofilm formation and grows as the biofilm matures, making deep fungal infections more difficult to cure (Eguia et al, 2020).…”

Section: Probiotics Can Inhibit the Formation Of Pathogenic Fungal Biofilmsmentioning

confidence: 99%

Probiotics: Potential Novel Therapeutics Against Fungal Infections

et al. 2022

Front. Cell. Infect. Microbiol.

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The global infection rate of fungal diseases is increasing year by year, and it has gradually become one of the most serious infectious diseases threatening human health. However, the side effects of antifungal drugs and the fungal resistance to these drugs are gradually increasing. Therefore, the development of new broad-spectrum, safe, and economical alternatives to antibacterial drugs are essential. Probiotics are microorganisms that are beneficial for human health. They boost human immunity, resist pathogen colonization, and reduce pathogen infection. Many investigations have shown their inhibitory activity on a wide range of pathogenic fungi. However, their antibacterial mechanism is still a secret. This article reviews the progress of probiotics as a new method for the treatment of fungal diseases.

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Candida albicans biofilms on different materials for manufacturing implant abutments and prostheses

Cited by 21 publications

References 28 publications

Fabrication and Physico-Chemical Properties of Antifungal Samarium Doped Hydroxyapatite Thin Films

Fabrication and Physico-Chemical Properties of Antifungal Samarium Doped Hydroxyapatite Thin Films

Oral Candidal Colonization in Patients with Different Prosthetic Appliances

Probiotics: Potential Novel Therapeutics Against Fungal Infections

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