Canine Papillomaviruses

Lange, Christian E.; Favrot, Claude

doi:10.1016/j.cvsm.2011.08.003

Cited by 61 publications

(91 citation statements)

References 75 publications

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“…The gross and histopathological features of the cutaneous lesions are consistent with those described in canine oral papillomas (Gross et al 2005, Ginn et al 2007, since the cytoplasmic alterations observed during this study are typical of viral-induced cytopathic effects and are diagnostic for this lesion (Gross et al 2005, Lange & Favrot 2011. Similar histopathological findings were recently described in dogs with oral papillomavirus from Korea identified by molecular biology (Yhee et al 2010) and in dogs from Brazil characterized by immunohistochemistry for Papillomavirus (Bianchi et al 2012), however the last investigation did not specify the PV type identified in dogs from Brazil.…”

Section: Discussionsupporting

confidence: 72%

“…Additionally, CPV13 was identified in oral papillomas (Lange et al 2012). Moreover, the histopathological characterization of canine viral papilloma is obtained by the finding of typical viral-induced alterations in the cytoplasm and/or nucleus of affected cells (Gross et al 2005, Lange & Favrot 2011. The role of CPV12 as a pathogen of papillomatosis has not been elucidated (Yuan et al 2012b unpublished data).…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, CPVs can be allocated into three distinct Papillomavirus genera: Lambdapapillomavirus (CPVs 1 and 6); Taupapillomavirus (CPVs 2, 7 and 13); and Chipapillomavirus (CPVs 3,4,5,8,9,10,11,and 14), while CPV 12 is not currently classified into a definite genus (Bernard et al 2010, Lange & Favrot 2011, Lange et al 2012.…”

Section: Introductionmentioning

confidence: 99%

“…CPV2 has already been isolated from exophytic and endophytic papillomas as well as invasive squamous cell carcinoma, CPV6 was isolated from endophytic papilloma, and CPV7 from an exophytic lesion (Lange & Favrot 2011). CPVs 3, 4, 5, 8, 9, 10, 11, and 14 are associated with the development of pigmented plaques (Lange et al 2013).…”

Section: Introductionmentioning

confidence: 99%

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Identification of canine papillomavirus type 1 (CPV1) DNA in dogs with cutaneous papillomatosis

et al. 2014

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Canine oral papillomavirus (COPV), also known as Canine Papillomavirus type 1 (CPV1), induces papillomas at the mucous membranes of the oral cavity and at the haired skin of dogs. The classification of Papillomavirus (PV) types is based on the L1 capsid protein and nucleotide sequence; so far, 14 CPV types have been described in several countries, but the molecular characterization of CPV in Brazil is lacking. This study investigated the presence of the PV in seven papillomas from four mixed breed dogs from Londrina/PR, Southern Brazil, by partial sequencing of the L1 gene. Seven exophytic cutaneous lesions were surgically removed and processed for histopathological and molecular characterization. Histopathology confirmed the lesions as viral papillomas due to typical histological features. Polymerase Chain Reaction (PCR) assay using the FAP59 and FAP64 primers targeted the L1 gene followed by sequence analysis of the amplicons identified CPV1 in all evaluated papilloma samples. This study represents the first description of CPV1 DNA associated with canine papillomatosis in Brazil.

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Section: Discussionsupporting

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Identification of canine papillomavirus type 1 (CPV1) DNA in dogs with cutaneous papillomatosis

et al. 2014

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“…FcaPV-3 is closely related to canine papillomavirus 2, a common cause of canine cutaneous papillomas (warts). 5 As cutaneous warts in dogs almost always resolve spontaneously, it is possible that TauPVs are only weakly carcinogenic. This is consistent with the mild dysplasia and absence of progression seen in the presently described FcaPV-3-associated BISC.…”

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confidence: 99%

The detection of Felis catus papillomavirus 3 DNA in a feline bowenoid in situ carcinoma with novel histologic features and benign clinical behavior

2016

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Brief CommunicationPapillomaviruses (PVs) are highly species-specific epitheliotropic DNA viruses. As part of their normal replication, PVs produce oncoproteins that disrupt normal cell regulation. 1 The vast majority of PV infections either do not result in the development of a visible lesion or cause a self-resolving hyperplastic wart. 7 However, the oncogenes produced by a small number of PV types can predispose an infected cell to neoplastic transformation. 1Disease resulting from PV infection is considered uncommon in cats. 8 To date, the disease that is most strongly associated with PV infection in cats is bowenoid in situ carcinoma (BISC; papillomavirus-associated squamous cell carcinoma in situ). 9,13 This neoplasm typically occurs as single or multiple scaly or crusting lesions within haired skin, especially around the head and neck. 4 Cats with BISCs may require euthanasia either because of the development of multiple BISCs or because of progression of a BISC to a squamous cell carcinoma (SCC). Devon Rex, and the closely related Sphinx, cats may be predisposed to BISCs, and BISCs in cats of these breeds are often rapidly progressive. 15A 17-year-old female Domestic Shorthair cat was presented to the primary care veterinarian because of a slightly raised 0.5 cm in diameter interscapular skin mass of uncertain duration.No tests were performed at this time, and a post-injection inflammatory reaction was suspected because the cat had received multiple subcutaneous injections at this location for the management of previously diagnosed diabetes mellitus and chronic renal failure. The mass was reported to have enlarged slowly, and 18 months later had doubled in size to 1 cm in diameter. The cat had no other skin lesions. The mass was surgically removed with 1-cm margins and submitted for histologic examination.On histologic examination, normal epidermis merged abruptly with a well-demarcated focus of marked, irregular epidermal hyperplasia. There were multiple, broad, downward-projecting rete pegs confined by the basement membrane and accompanying mild parakeratosis, hyperkeratosis, and variable melanization. The epidermal hyperplasia also Abstract. Bowenoid in situ carcinoma (BISC; papillomavirus-associated squamous cell carcinoma in situ) is an uncommon skin neoplasm of cats that can result in euthanasia because of the development of multiple lesions or because of progression to invasive squamous cell carcinoma. BISCs are currently thought to be caused by Felis catus papillomavirus 2 (FcaPV-2). The presently described cat developed a single 0.5 cm in diameter interscapular mass. Over the following 18 months, the mass doubled in size; no additional lesions developed. The mass was surgically excised and histologically diagnosed as a BISC. However, in contrast to previously reported BISCs, neither prominent thickening of the deep aspects of the follicular infundibula nor marked cell dysplasia were present. Furthermore, ~50% of the keratinocytes in the affected epidermis had prominent PV cytopathic changes that...

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