Cardiac troponin I in acute coronary ischemic syndromes. Epidemiological and clinical correlates

Lucia, P; Coppola, Alessandro; Manetti, Luca; Sebastiani, Mariangela; Colliardo, A.; Cerroni, Fabio; Martinis, C. De; Strappini, P. M.

doi:10.1016/s0167-5273(00)00429-0

Cited by 10 publications

(7 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This hypothesis would be supported by previous studies conducted in human and animal models. In human patients, it has been demonstrated that troponin-I reaches the peak plasma concentration approximately 6 h after acute myocardial damage (Lucia et al, 2001). A similar and reversible peak was observed with serum troponin-T in rats after a prolonged and intense exercise (Chen et al, 2000) and in athletes after an ultra-marathon race (160 km) in extreme environmental conditions (Laslett, 1996).…”

Section: Discussionmentioning

confidence: 76%

A Pilot Study to Assess the Feasibility of a Submaximal Exercise Test to Measure Individual Response to Cardiac Medication in Dogs with Acquired Heart Failure

Ferasin

Marcora

2007

Vet Res Commun

View full text Add to dashboard Cite

Exercise testing is not commonly used in canine medicine because of several limitations. The aim of this study was to investigate the suitability of a treadmill test to measure the exercise capacity of untrained canine cardiac patients and to measure some biological parameters that might reflect the tolerance of dogs with heart failure to submaximal exercise. The exercise capacity of seven dogs with naturally occurring heart failure was evaluated before the institution of cardiac medication and 7 days after the beginning of the study. An additional re-examination was requested after 28 days. The exercise test was performed on a motorized treadmill at three different speeds (0.5 m/s, 1.0 m/s and 1.5 m/s). The following parameters were measured at the end of each stage and after 20 min recovery: heart rate, rectal temperature, glucose, lactate, aspartate aminotransferase, creatine kinase, PvO(2), PvCO(2), pH, haematocrit, bicarbonate, sodium, potassium and chloride. Serum cardiac troponin-I was also measured at the beginning of the test and at the end of the recovery period. Owners' perception reflected the ability of their dogs to exercise on the treadmill. Lactate level increased noticeably with the intensity of the exercise test, and its variation coincided with different exercise tolerance observed by the owners. Heart rate seemed to follow a similar trend in the few dogs presented in sinus rhythm. None of the remaining parameters appeared to be sensitive indicators of activity level in the dogs used in this study. The treadmill exercise test in dogs with acquired heart failure is feasible and might provide useful information for assessing individual response to cardiac medication. Lactate and heart rate seemed to reflect individual levels of exercise tolerance, although further studies are necessary to confirm the reliability and repeatability of this test.

show abstract

Section: Discussionmentioning

confidence: 76%

A Pilot Study to Assess the Feasibility of a Submaximal Exercise Test to Measure Individual Response to Cardiac Medication in Dogs with Acquired Heart Failure

Ferasin

Marcora

2007

Vet Res Commun

View full text Add to dashboard Cite

show abstract

“…Because cTnI has been reported to reach peak serum levels hours after a cardiac event [ 34 , 39 ], it was measured before and 3 hours after the ET. Samples for cTnI and NT-proBNP were stored on ice within seconds after extraction.…”

Section: Methodsmentioning

confidence: 99%

Clinical use of submaximal treadmill exercise testing and assessments of cardiac biomarkers NT-proBNP and cTnI in dogs with presymptomatic mitral regurgitation

et al. 2018

View full text Add to dashboard Cite

Exercise intolerance is the first symptom of heart disease. Yet an objective and standardised method in canine cardiology to assess exercise capacity in a clinical setting is lacking. In contrast, exercise testing is a powerful diagnostic tool in humans, providing valuable information on prognosis and impact of therapeutic intervention. To investigate whether an exercise test reveals differences between dogs with early stage mitral regurgitation (MR) and dogs without cardiac disease, 12 healthy beagles (healthy group, HG) and 12 dogs with presymptomatic MR (CHIEF B1 / B2, patient group, PG) underwent a six-stage submaximal exercise test (ET) on a motorised treadmill. They trotted in their individual comfort speed for three minutes per stage, first without incline, afterwards increasing it by 4% for every subsequent stage. Blood samples were taken at rest and during two 3-minute breaks in the course of the test. Further samples were taken after the completion of the exercise test and again after a 3-hour recovery period. Measured parameters included heart rate, lactate and the cardiac biomarkers N-terminal pro-B-Type natriuretic peptide and cardiac Troponin I. The test was performed again under the same conditions in the same dogs three weeks after the first trial to evaluate individual repeatability. Cardiac biomarkers increased significantly in both HG and PG in the course of the test. The increase was more pronounced in CHIEF B1 / B2 dogs than in the HG. N-terminal pro-B-Type natriuretic peptide increased from 435 ± 195 to 523 ± 239 pmol/L (HG) and from 690 to 815 pmol/L (PG). cTnI increased from 0.020 to 0.024 ng/mL (HG) and from 0.06 to 0.08 ng/ml (PG). The present study provides a method to assess exercise-induced changes in cardiac biomarkers under clinical conditions. The increase of NT-proBNP and cTnI is more pronounced in dogs with early-stage MR than in healthy dogs. Results indicate that measuring the parameters before and after exercise is adequate and taking blood samples between the different stages of the ET does not provide additional information. Also, stress echocardiography was inconclusive. It can be concluded that exercise testing, especially in combination with measuring cardiac biomarkers, could be a helpful diagnostic tool in canine cardiology.

show abstract

“…The myofibrillar protein troponin I (Trop I) has emerged as a more sensitive and specific marker of myocyte injury than creatine kinase (CK) and has improved the diagnosis, risk stratification, and care of patients with acute coronary syndromes [1][2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Trends in inflammatory biomarkers during atrial fibrillation ablation across different catheter ablation strategies

Schmidt

Marschang

Clifford

et al. 2012

International Journal of Cardiology

View full text Add to dashboard Cite

Cardiac troponin I in acute coronary ischemic syndromes. Epidemiological and clinical correlates

Cited by 10 publications

References 43 publications

A Pilot Study to Assess the Feasibility of a Submaximal Exercise Test to Measure Individual Response to Cardiac Medication in Dogs with Acquired Heart Failure

A Pilot Study to Assess the Feasibility of a Submaximal Exercise Test to Measure Individual Response to Cardiac Medication in Dogs with Acquired Heart Failure

Clinical use of submaximal treadmill exercise testing and assessments of cardiac biomarkers NT-proBNP and cTnI in dogs with presymptomatic mitral regurgitation

Trends in inflammatory biomarkers during atrial fibrillation ablation across different catheter ablation strategies

Contact Info

Product

Resources

About