Cariostatic effects of a xylitol/NaF dentifrice in vivo

Abstract

Xylitol has been shown to reduce plaque acids, but its topical cariostatic effect has been equivocal. The purpose of the studies reported here was to optimise the xylitol/NaF combination in dentifrices for an improved anticaries activity. In the first study, the combination of 10 per cent xylitol with 1100 ppm F (NaF), 1100 ppm F (NaF), and placebo dentifrices were tested in a rat caries model to assess the cariostatic effect. The combination was significantly more effective than fluoride by itself (P = 0.05). The xylitol/NaF combination provided significantly more remineralisation of dentine than fluoride by itself. Collectively, results of these investigations confirm the improved anticaries effectiveness of the xylitol/NaF combination in a variety of animal and intra-oral models. A three-year clinical study confirmed these findings.

Effect of a Triclosan-Containing Toothpaste Supplemented with 10% Xylitol on Mutans Streptococci in Saliva and Dental Plaque

“…One of three longitudinal clinical dentifrice studies indicates a cariesreducing effect of xylitol [Sintes et al, 1995], while the two others failed to demonstrate an additive effect of xylitol when added to fluoride-containing toothpaste [Petersson et al, 1991;Cutress et al, 1992]. Animal and intraoral remineralization studies confirm the improved anticaries effectiveness of the xylitol/NaF combination compared to NaF toothpaste [Gaffar et al, 1998]. On the other hand, xylitol added to mouthrinse solutions has shown limited effect on plaque amounts, gingival conditions and oral microflora [Lingström et al, 1997;Giertsen et al, 1999].…”

Effect of a xylitol and fluoride containing toothpaste on the remineralization of human enamel in vitro

“…Gaffar et al (9) demonstrated that the combination of 10% xylitol and 1,100 ppm F -(NaF) toothpaste was significantly more effective than fluoride itself for cariostatic effects in rats. Moreover, they showed that the combination provided significantly more remineralization of dentine than fluoride alone in situ.…”

Di̇ş Heki̇mli̇ği̇nde Kullanilan Remi̇nerali̇zasyon Ajanlari Ve Çürük Önleyi̇ci̇ Ajanlar

“…Bradshaw ve arkadaşları 31 , ksilitolün hedef mikroorganizmasının mutans streptokoklar olduğunu bildirmişlerdir. Gaffar ve arkadaşları 32 , ksilitol, NaF ve ksilitol+NaF içerikli diş macunlarının remineralizasyon üzerine etkilerinin inceledikleri çalışmalarında, ksilitol+Flor kombinasyonunun tek başına flor ya da tek başına ksilitol içeren diş macunlarından anlamlı derecede daha fazla remineralizasyon meydana getirdiğini bulmuşlardır.…”