CASE REPORT: Primary hepatic lymphoma associated with chronic liver disease

Higuchi, Takakazu; Nomoto, Kazuhiko; Mori, Hiraku; Niikura, H; Omine, Mitsuhiro; Sekiyama, Kazuhiko; Yoshiba, Makoto; Fujita, Rikiya

doi:10.1111/j.1440-1746.1997.tb00415.x

Cited by 13 publications

(13 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, NHL develops and grows in the liver primarily in some patients and is then called primary hepatic NHL. [13][14][15][16][17] Whether its involvement is primary or secondary, liver is not an uncommon target organ for NHL. AHF caused by hepatic involvement of NHL, however, is very rare.…”

Section: Discussionmentioning

confidence: 99%

Acute hepatic failure due to hepatosplenic B-cell non-Hodgkin's lymphoma in a patient infected with hepatitis C virus

Yoshikawa

Yamane²,

Yoneda³

et al. 1998

Journal of Gastroenterology

View full text Add to dashboard Cite

We report a 75-year-old Japanese man infected with hepatitis C virus (HCV) who died of acute hepatic failure due to the hepatic infiltration of B-cell non-Hodgkin's lymphoma (NHL) cells. He suddenly developed jaundice, fatigue, fever, and hepatosplenomegaly during the course of chronic infection with HCV. Postmortem liver necropsy revealed extensive infiltration of lymphoma cells into the liver. Although the association between HCV infection and NHL has recently become a matter of concern, we believe this to be the first reported case of acute hepatic failure caused by hepatic involvement of non-Hodgkin's lymphoma in an HCV-infected patient.

show abstract

Section: Discussionmentioning

confidence: 99%

Acute hepatic failure due to hepatosplenic B-cell non-Hodgkin's lymphoma in a patient infected with hepatitis C virus

Yoshikawa

Yamane²,

Yoneda³

et al. 1998

Journal of Gastroenterology

View full text Add to dashboard Cite

show abstract

“…[4][5][6][7] The patient with SS we have described here had no past history of liver disease. Primary biliary cirrhosis (PBC) is known to be one of the most frequent liver diseases associated with SS, with a reported incidence of 3%-9% in SS patients.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3] According to previous reports, [4][5][6] PHL tends to coexist with chronic liver diseases, including viral hepatitis and cirrhosis, this being particularly notable in Japan. 7 In certain instances, PHL arises in patients with immune abnormalities, including those caused by systemic lupus erythematosus, 8 acquired immune deficiency syndrome, 4,9,10 or immunosuppressive treatment.…”

Section: Introductionmentioning

confidence: 99%

Primary hepatic lymphoma in a patient with Sjögren's syndrome

Tsuruta

Enjoji

Nakamuta

et al. 2002

Journal of Gastroenterology

View full text Add to dashboard Cite

We report a case of primary hepatic lymphoma (PHL) that developed in a patient with well controlled Sjogren's syndrome (SS) who had been receiving long-term prednisolone treatment. The tumor, found incidentally by ultrasonography, was shown as an extremely large, solitary liver mass that exhibited the immunohistological features of a B-cell lymphoma. An intensive regimen of chemotherapy induced complete regression of this mass. SS occasionally gives rise to lymphoma in salivary glands, however, there have been no previous reports of PHL in a patient with SS. This case study raises the possibility that SS itself, a form of autoimmune disease, and/or prednisolone-based immunosuppressive treatment for SS, predisposes to the occurrence of PHL. SS patients should be monitored vigilantly for the occurrence of extranodal lymphoma, including PHL, even if the SS is well controlled.

show abstract

“…Only one of the three patients was immune-suppressed, and none presented with signs of chronic hepatopathy. Association of primary hepatic lymphoma with cirrhosis and chronic hepatitis has been described in 30% of cases (12)(13)(14)(15) . Although the reason for this association still remains unclear, the diagnosis of NHL should be considered in cirrhotic patients with voluminous hepatic mass and normal alphafetoprotein levels.…”

Section: Discussionmentioning

confidence: 99%

Linfoma não-Hodgkin apresentando-se como massa hepática única

et al. 2009

View full text Add to dashboard Cite

OBJECTIVE: To describe the main imaging findings of non-Hodgkin's lymphoma presenting as a single liver mass. MATERIALS AND METHODS: A retrospective study was developed with analysis of cases where a single liver mass was observed at ultrasonography, computed tomography and magnetic resonance imaging, and histologically diagnosed as non-Hodgkin's lymphoma. The studies were reviewed by two observers in consensus. RESULTS: Three male patients in the fifth decade of life, with non-specific clinical manifestations and single liver mass diagnosed as non-Hodgkin's lymphoma were identified. A hepatic lesion with target sign was observed at ultrasonography in all of the cases. At computed tomography, all the patients presented a heterogeneous, hypodense mass with a ring enhancement. At magnetic resonance imaging, the lesions were heterogeneous and hypointense on T1-weighted and hyperintense on T2-weighted images. Additionally, a ring enhancement was observed in all of the cases after contrast injection. At the moment of the diagnosis, none of the patients presented lymphadenomegaly or involvement of other solid viscera. CONCLUSION: The diagnosis of hepatic lymphoma should be considered in the presence of a ring-enhanced single liver mass. Keywords: Lymphoma; Liver; Ultrasonography; Computed tomography; Magnetic resonance imaging.OBJETIVO: Descrever as principais características de imagem do linfoma não-Hodgkin apresentando-se como massa hepática única. MATERIAIS E MÉTODOS: Realizamos estudo retrospectivo mediante análise de casos de pacientes com massa hepática única aos exames de ultrassonografia, tomografia computadorizada e ressonância magnética, com diagnóstico histológico de linfoma não-Hodgkin. Esses exames foram analisados por dois examinadores em consenso. RESULTADOS: Identificamos três pacientes, todos do sexo masculino, na quinta década de vida, com quadro clínico inespecífico e que apresentavam massa hepática única e com diagnóstico de linfoma não-Hodgkin. Na ultrassonografia a lesão hepática apresentava-se como massa com aspecto "em alvo" nos três casos estudados. Na tomografia computadorizada observou-se massa hipodensa e heterogênea, com realce anelar em todos os casos. Na ressonância magnética as lesões apresentavam-se heterogêneas, hipointensas em T1 e hiperintensas em T2, e também com realce anelar após a injeção do contraste. Nenhum paciente apresentava linfonodomegalia ou comprometimento de outras vísceras sólidas no momento do diagnóstico. CONCLUSÃO: Na presença de massa hepática solitária e com aspecto "em alvo" deve-se considerar, entre as hipóteses, o diagnóstico de linfoma. Unitermos: Linfoma; Fígado; Ultrassonografia; Tomografia computadorizada; Imagem por ressonância magnética. AbstractResumo

show abstract

CASE REPORT: Primary hepatic lymphoma associated with chronic liver disease

Cited by 13 publications

References 50 publications

Acute hepatic failure due to hepatosplenic B-cell non-Hodgkin's lymphoma in a patient infected with hepatitis C virus

Acute hepatic failure due to hepatosplenic B-cell non-Hodgkin's lymphoma in a patient infected with hepatitis C virus

Primary hepatic lymphoma in a patient with Sjögren's syndrome

Linfoma não-Hodgkin apresentando-se como massa hepática única

Contact Info

Product

Resources

About