Cefazolin-loaded polycaprolactone fibers produced via different electrospinning methods: Characterization, drug release and antibacterial effect

Radisavljevic, Andjela; Stojanović, Dušica; Perišić, Srdjan; Djokić, Veljko; Radojević, Vesna; Rajilić‐Stojanović, Mirjana; Uskoković, Dragan

doi:10.1016/j.ejps.2018.08.023

Cited by 51 publications

(29 citation statements)

References 61 publications

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“…Likewise, higher conductivity and lower viscosity and surface tension altered the polymer chain entanglements, generating an increase in the stretching forces in the jet which resulted in the decreased electrospun fiber diameters [6,40]. Similarly, decreased diameter of PCL fibers was reported when other active compounds, such as black pepper oleoresins [25], carvacrol [41], or cefazolin [42] were incorporated within the polymeric matrix.…”

Section: Resultsmentioning

confidence: 99%

Physicochemical, Antioxidant and Antimicrobial Properties of Electrospun Poly(ε-caprolactone) Films Containing a Solid Dispersion of Sage (Salvia officinalis L.) Extract

et al. 2019

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In this study, novel active films made of poly(ε-caprolactone) (PCL) containing a solid dispersion of sage extract (SE) were developed by means of the electrospinning technique and subsequent annealing treatment. Initially, the antioxidant and antimicrobial potential of SE was confirmed. Thereafter, the effect of SE incorporation at different loading contents (5%, 10%, and 20%) on the physicochemical and functional properties of the films was evaluated. The films were characterized in terms of morphology, transparency, water contact angle, thermal stability, tensile properties, water vapor, and aroma barrier performances, as well as antioxidant and antimicrobial activities. Thin, hydrophobic films with good contact transparency were produced by annealing of the ultrathin electrospun fibers. Interestingly, the effect of SE addition on tensile properties and thermal stability of the films was negligible. In general, the water vapor and aroma permeability of the PCL-based films increased by adding SE to the polymer. Nevertheless, a strong 2,2-diphenyl-1-picrylhydrazyl (DPPH·) free radical scavenging ability, and a strong activity against foodborne pathogens Staphylococcus aureus and Escherichia coli were achieved by SE incorporation into PCL matrix. Overall, the obtained results suggest great potential of the here-developed PCL-based films containing SE in active food packaging applications with the role of preventing oxidation processes and microbial growth.

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Section: Resultsmentioning

confidence: 99%

Physicochemical, Antioxidant and Antimicrobial Properties of Electrospun Poly(ε-caprolactone) Films Containing a Solid Dispersion of Sage (Salvia officinalis L.) Extract

et al. 2019

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“…BBR increased the conductivity of the polymer solution, as the conductivity of the solution increased, the charge on the surface of the droplet increased, resulting in a decrease of fiber diameter 26 . Furthermore, BBR has a large charge density, and the large charge density increases the self-repulsion and the stretching force when droplet passes through the electrostatic field, also leads to the decrease of fiber diameter 27 . Our results are consistent with previous researchers 28 , 29 .…”

Section: Discussionmentioning

confidence: 99%

Berberine-releasing electrospun scaffold induces osteogenic differentiation of DPSCs and accelerates bone repair

Liu

et al. 2021

Sci Rep

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The repair of skeletal defects in maxillofacial region remains an intractable problem, the rising technology of bone tissue engineering provides a new strategy to solve it. Scaffolds, a crucial element of tissue engineering, must have favorable biocompatibility as well as osteoinductivity. In this study, we prepared berberine/polycaprolactone/collagen (BBR/PCL/COL) scaffolds with different concentrations of berberine (BBR) (25, 50, 75 and 100 μg/mL) through electrospinning. The influence of dosage on scaffold morphology, cell behavior and in vivo bone defect repair were systematically studied. The results indicated that scaffolds could release BBR stably for up to 27 days. Experiments in vitro showed that BBR/PCL/COL scaffolds had appropriate biocompatibility in the concentration of 25–75 μg/mL, and 50 and 75 μg/mL scaffolds could significantly promote osteogenic differentiation of dental pulp stem cells. Scaffold with 50 μg/mL BBR was implanted into the critical bone defect of rats to evaluate the ability of bone repair in vivo. It was found that BBR/PCL/COL scaffold performed more favorable than polycaprolactone/collagen (PCL/COL) scaffold. Overall, our study is the first to evaluate the capability of in vivo bone repair of BBR/PCL/COL electrospun scaffold. The results indicate that BBR/PCL/COL scaffold has prospective potential for tissue engineering applications in bone regeneration therapy.

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“…produced cefazolin‐loaded PCL fibers following three electrospinning methods: blend, emulsion, and co‐axial electrospinning. [ 239 ] Drug release experiments indicated that the blend and co‐axial electrospun fibers possessed higher release rates (≈68% and ≈43%, respectively) compared to the emulsion electrospun fibers (≈5%) over a 30 day period. In antibacterial assays, cefazolin‐loaded PCL fibers exhibited a more durable inhibitory effect on S. aureus than E. coli during treatment.…”

Section: Inhibitory Biological Process On Bacteriamentioning

confidence: 99%

“…Inhibits the protein synthesis of bacteria [237] Gentamicin Inhibits the protein synthesis of bacteria [238] Cefazolin Prevents the synthesis of the bacterial cell wall [239] Chloramphenicol Inhibits the protein synthesis of bacteria [240] Moxifloxacin Inhibits the DNA synthesis of bacteria [241] antibacterial effect of the mat was assessed by inhibition zone testing and biofilm formation testing in vitro, and was found to inhibit MRSA biofilm formation on the surface of ossicular prostheses in vitro or MRSA otitis media in vivo. Moreover, Radisavljevic et al produced cefazolin-loaded PCL fibers following three electrospinning methods: blend, emulsion, and co-axial electrospinning.…”

Section: Doxycyclinementioning

confidence: 99%

Two Sides of Electrospun Fiber in Promoting and Inhibiting Biomedical Processes

Wang

Cui

2020

Advanced Therapeutics

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Electrospinning is a versatile technique for generating ultrathin fibers, which is widely applied in various biomedical applications. The properties and structures of the fibers are specifically engineered to meet the needs of particular applications. The impact of nanofibrous scaffolds on biological processes is related to the promotion or inhibition of specific cell or bioactive substance functions. Here, a novel analysis of the diverse roles of electrospun nanofibrous scaffolds is provided and recent advances in exploiting their binary attributes for applications in biomedicine are summarized. This review initially introduces the development techniques for electrospinning, specifically the engineering of electrospun nanofibers. Then, scaffold applications for cell migration, adhesion, proliferation, and accelerating regeneration in cardiac, nerve, skeletal muscle, bone tissue, and wound healing are presented. Moreover, their inhibitory properties in cancer treatments, antibacterial applications, anti‐adhesion, anti‐scarring, and inhibition of thrombus formation are summarized. Eventually, the potential for future work using multifunctional, electrospun, nanofibrous scaffolds, in order to further inspire the development of scaffolds for biomedical treatments is summarized and discussed.

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Cefazolin-loaded polycaprolactone fibers produced via different electrospinning methods: Characterization, drug release and antibacterial effect

Cited by 51 publications

References 61 publications

Physicochemical, Antioxidant and Antimicrobial Properties of Electrospun Poly(ε-caprolactone) Films Containing a Solid Dispersion of Sage (Salvia officinalis L.) Extract

Physicochemical, Antioxidant and Antimicrobial Properties of Electrospun Poly(ε-caprolactone) Films Containing a Solid Dispersion of Sage (Salvia officinalis L.) Extract

Berberine-releasing electrospun scaffold induces osteogenic differentiation of DPSCs and accelerates bone repair

Two Sides of Electrospun Fiber in Promoting and Inhibiting Biomedical Processes

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