Celebrating Ten Years

In vivo and in vitro evaluation of highly specific thiolate carrier group copper(II) and zinc(II) complexes on Ehrlich ascites carcinoma tumor model

“…Linearity of the i pc versus square root of scan rate plot (passing through origin) and the values of i pa /i pc (z1) suggest that the redox tends to become fairly reversible. The redox potentials of the present complexes follow the trends [CuL 4 …”

“…Pt(II) has a strong thermodynamic preference for binding to S-donor ligands. For that reason, one would predict that platinum compounds would perhaps never reach DNA, with many cellular platinophiles (S-donor ligands, such as glutathione, methionine) as competing ligands in the cytosol [3,4]. Despite the success of cisplatin, however, it lacks selectivity for tumor tissue, which leads to severe side effects.…”

Synthesis, Crystal Structure, DNA Binding, and Hydrolytic Cleavage Activity of a Manganese(II) Complex

“…[1][2][3][4][5][6][7][8][9][10] Chemical nucleases present some advantages over conventional enzymatic nucleases in that they are smaller in size and thus can reach more sterically hindered regions of a macromolecule. Many of these utilize the redox properties of the metal and dioxygen to produce reactive oxygen species that oxidize DNA, thereby yielding direct strand scission or base modification.…”

New ternary copper(II) complexes of l-alanine and heterocyclic bases: DNA binding and oxidative DNA cleavage activity

“…Substantial progress has been made during the past few decades to develop metal-based small molecules as DNA foot-printing as well as the therapeutic agents that are capable of binding and cleaving DNA under the physiological condition [1][2][3][4][5][6][7][8][9][10][11][12]. Metal complexes, in this context, with tunable coordination environments and versatile physicochemical properties offer scope for designing and developping highly sensitive diagnostic agents for medicinal applications as exemplified by the chemotherapeutic agents such as cis-platin and bleomycins [13][14][15].…”