Cell Calcium, Cell Injury and Cell Death

Trump, Benjamin F.; Berezesky, Irene K.; Sato, Toshihide; Laiho, K.; Phelps, Patricia C.; DeClaris, N.

doi:10.2307/3429928

Cited by 37 publications

(34 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This Na + -Ca 2+ exchange mechanism may play a role in regulating the cellular calcium level. 43) The significant decrease in Na + -K + ATPase and increase in Ca 2+ and Mg 2+ ATPase in our DOX administered rats were concurred with the previous findings. The increased activity of Na + -K + ATPase upon administration of N. jatamansi might regulate the intracellular Ca 2+ level there by protecting the myocardium from excess damage by maintaining the membrane integrity.…”

Section: Discussionsupporting

confidence: 81%

Protective Efficacy of Nardostachys jatamansi (Rhizomes) on Mitochondrial Respiration and Lysosomal Hydrolases during Doxorubicin Induced Myocardial Injury in Rats

Subashini

Arunachalam

Senthilkumar

et al. 2007

JOURNAL OF HEALTH SCIENCE

View full text Add to dashboard Cite

Doxorubicin is highly effective in treatment for several forms of cancer. However, doxorubicin induces a cumulative and dose dependent cardiomyopathy that has been ascribed to redox-cycling of the molecule on the mitochondrial complex 1 generating in the process of increased oxidative stress. In the search of new potential cardioprotective agents, the present study is directed to explore the effect of ethanolic extract of Nardostachys jatamansi on the mitochondrial and lysosomal damage induced by doxorubicin in rats. Heart mitochondria were isolated from rats treated with doxorubicin (15 mg/kg, ip) a single dose, exhibited depressed rates of state 3 respiration, low respiratory control ratio (RCR), decreased Oxidative Phosphorylation ratio, Adenosine Triphosphate content and cytochromes (c, c 1 , b, aa 3 ). In addition the doxorubicin given rats showed significant changes in the lysosomal enzymes (Cathepsin-D, Acid phosphatase, β-D-glucoronidase, β-D-galactosidase and β-N-acetyl glucosaminidase) and membrane bound phosphatases. Also myocardial damage, as assessed by ultrastructural changes showed loss of myofibrils, mitochondrial swelling, and cytoplasmic vacuolization. Pretreatment with Nardostachys jatamansi (500 mg/kg body weight orally) for seven days ameliorated the observed abnormalities and significantly prevented the mitochondrial respiration, lysosomal integrity, membrane bound phosphatases and ultrastructural studies in doxorubicin induced rats. These findings suggest that the cardioprotective efficacy of Nardostachys jatamansi could be mediated possibly through its antioxidant effect as well as by the attenuation of the oxidative stress.

show abstract

Section: Discussionsupporting

confidence: 81%

Protective Efficacy of Nardostachys jatamansi (Rhizomes) on Mitochondrial Respiration and Lysosomal Hydrolases during Doxorubicin Induced Myocardial Injury in Rats

Subashini

Arunachalam

Senthilkumar

et al. 2007

JOURNAL OF HEALTH SCIENCE

View full text Add to dashboard Cite

show abstract

“…39 Morphological abnormalities defining irreversible cellular injury were necrosis and apoptosis. We applied criteria developed by Farber et al 40 and Trump et al, 41 who outlined morphological features (light and electron microscopy) of necrotic cells. Necrotic injury included pyknotic nuclei exhibiting an intense eosinophilic cytoplasm (red neurons) and nuclei lacking cellular structures (ghost neurons).…”

Section: Histological Assessment Of Neuronal Damagementioning

confidence: 99%

Neuronal Damage and Plasticity Identified by Microtubule-Associated Protein 2, Growth-Associated Protein 43, and Cyclin D1 Immunoreactivity After Focal Cerebral Ischemia in Rats

Jiang

Powers

et al. 1998

Stroke

209

121

View full text Add to dashboard Cite

Background and Purpose-An objective of therapeutic intervention after cerebral ischemia is to promote improved functional outcome. Improved outcome may be associated with a reduction of the volume of cerebral infarction and the promotion of cerebral plasticity. In the developing brain, neuronal growth is concomitant with expression of particular proteins, including microtubule-associated protein 2 (MAP-2), growth-associated protein 43 (GAP-43), and cyclin D1.In the present study we measured the expression of select proteins associated with neurite damage and plasticity (MAP-2 and GAP-43) as well as cell cycle (cyclin D1) after induction of focal cerebral ischemia in the rat. Methods-Brains from rats (nϭ28) subjected to 2 hours of middle cerebral artery occlusion and 6 hours, 12 hours, and 2, 7, 14, 21, and 28 days (nϭ4 per time point) of reperfusion and control sham-operated (nϭ3) and normal (nϭ2) rats were processed by immunohistochemistry with antibodies raised against MAP-2, GAP-43, and cyclin D1. Double staining of these proteins for cellular colocalization was also performed. Results-Loss of immunoreactivity of both MAP-2 and GAP-43 was observed in most damaged neurons in the ischemic core. In contrast, MAP-2, GAP-43, and cyclin D1 were selectively increased in morphologically intact or altered neurons localized to the ischemic core at an early stage (eg, 6 hours) of reperfusion and in the boundary zone to the ischemic core (penumbra) during longer reperfusion times. Conclusions-The

show abstract

“…Still other reports for avariety of viruses indicate the formation of cytoplasmic, membranous structures, such as annulate lamellae, multivesicular bodies, and concentric membrane masses from ER, outer nuclear envelope and other organelles (Kim & Boatman 1967, Merkow et al 1970 Russo et al 1987); usually, these authors did not suggest functions other than aberiant virus assembly processes for these membranous structures The derivation of the ML, in BP-crustacean cell systems, from the very flexible Golgi, outer nuclear envelope and ER, all part of the cytocavitary system of the cell (Trump & Arstila 1971, Porter & Bonneville 1968, and the known role of this membrane-bound system in cells, suggests that viruses could turn thls role of packaging and transporting proteln and complex carbohydrates to their own needs in reproduction. If this were the case in the ML, then the direction of flow of these proteins and perhaps other precursor substance would be (under virus control) largely reversed toward the nucleus where nuclear, DNA virus assembly and occlusion body formation occurs, rather than toward the plasma membrane where normal secretion of synthesized, cellular products occurs.…”

mentioning

confidence: 99%

The membranous labyrinth in baculovirus-infected crustacean cells: possible roles in viral reproduction

Couch¹

1989

Dis. Aquat. Org.

View full text Add to dashboard Cite

The origins and morphogenesis of the membranous labyrinth (ML) in Baculov~rus penaei (BP) infected cells of penaeid shrimps (Crustacea:Decapoda) are described. The \IL is usually a highly ordered, complex system of membranes arranged as a labyrinth or in concentric form in the cytoplasm near or against the nuclear envelope. The ML originates from dilated Golgi and endoplasmic reticulum vesicles, and from the outer nuclear envelope. It grows apparently from proliferation of the cellular membranes of these systems, and its developn~ent may be correlated with the stages of BP infection. It is hypothesized that, because of the close parallel and concurrent developnlent of the ML and virus reproduction, and other evidence, the ML is virus-~nduced and -controlled and may play at least 3 roles In the virus reproductive strategy: (1) provides a conduit or transport system for viral precursors from cytoplasm to nucleus; (2) provides ~ncreasc!d membrane surface and volume for increased ATPase activity (related to energy demand for virus reproduction and transport of viral products); and (3) provides a mechanism for cell collapse and release of virus and occlusion bodies at the end of virus reproduction period. Possible experimental methods with which to determine the functional role of the ML are discussed and implications for such a system for nuclear. DNA, viruses are considered.

show abstract

Cell Calcium, Cell Injury and Cell Death

Cited by 37 publications

References 1 publication

Protective Efficacy of Nardostachys jatamansi (Rhizomes) on Mitochondrial Respiration and Lysosomal Hydrolases during Doxorubicin Induced Myocardial Injury in Rats

Protective Efficacy of Nardostachys jatamansi (Rhizomes) on Mitochondrial Respiration and Lysosomal Hydrolases during Doxorubicin Induced Myocardial Injury in Rats

Neuronal Damage and Plasticity Identified by Microtubule-Associated Protein 2, Growth-Associated Protein 43, and Cyclin D1 Immunoreactivity After Focal Cerebral Ischemia in Rats

The membranous labyrinth in baculovirus-infected crustacean cells: possible roles in viral reproduction

Contact Info

Product

Resources

About