Cellular hypersensitivity to components of intestinal mucosa in ulcerative colitis and Crohn's disease

Leucocytes from patients with colon carcinoma or non-cancerous intestinal disease react differently to foetal colon extract in leucocyte migration inhibition test

“…Stimulation of leucocyte migration was the more frequent reaction. By contrast, leucocytes of non-cancerous patients were often strongly inhibited by foetal colon extract at various concentrations (similar results had been obtained by Bendixen (1969)). One can wonder whether this discrepancy was due to a difference in the intensity of leucocyte sensitization, or reactions to different antigens.…”

Leucocyte migration studies in Crohn's disease using Crohn's colon homogenate and mitochondrial and microsomal fractions

“…It has been shown that extracts of fetal, colonic, and jejunoileal mucosas inhibit migration of leucocytes from patients with ulcerative colitis, but not those with Crohn's disease (Bendixen, 1969). Our studies show migration inhibition of leucocytes from patients with Crohn's disease against Crohn's colon, and a further immunological differentiation between the two conditions would be apparent if further work showed that leucocytes from ulcerative colitis patients did not react in this way.…”

“…These studies, using the leucocyte migration technique, showed evidence of hypersensitivity to sarcoid spleen in a proportion of the Crohn's patients. The technique had previously shown no evidence of hypersensitivity to extracts of foetal colonic and jejunal mucosa in Crohn's disease, although leucocytes from a majority ofpatients with ulcerative colitis had shown inhibited migration to these extracts (Bendixen, 1969).…”

Immunopathology of ulcerative colitis and Crohn's disease, nonsurgical therapeutic considerations

“…A suppression of delayed type skin reaction is seen in nearly 60% of cases, together with an increased synthesis of migration inhibiting factors following colonic antigen specific stimulation of lymphocytes, and cytotoxic reactions by circulating lymphocytes against fetal and adult colonic epithelial cells. Colon antigen primed lymphocytes in peripheral blood, a decrease of the in vitro induced activity of suppressor cells and a decrease of helper and suppressor cells probably due to an enteral loss may also be detected [4,16,23,33,45]. All these observed pathologic immunoreactions do not necessarily reflect the situation in affected tissue.…”