Cellular regeneration and proliferation on polymeric 3D inverse-space substrates and the effect of doxorubicin

Abstract

2D substrates promote cell attachment with lateral compression; 3DIS scaffolding restores the 3D cell structure allowing more realistic cellular-drug responses.

A graphene-sandwiched DNA nano-system: regulation of intercalated doxorubicin for cellular localization

“…We have also reported earlier that higher anticancer drug levels ($IC 50 ) may be crucial in controlling the proliferation of cancer cells. 41 The results suggest molecular tunability of NPs to alter cell entry kinetics, cellular localization depending on the nature of the drug and residence time to suit the pharmacological need. and were demonstrated to be efficient organelle-selective drug delivery systems that inuenced the characteristic morphological adaptations in HeLa cells.…”

A Near-Infrared Mechanically Switchable Elastomeric Film as a Dynamic Cell Culture Substrate

“…To further confirm greater FA clustering by fibroblasts when cultured on PDMS/Au NRs NIR films, levels of secretion of TGF-β1 by fibroblasts were quantified by employing an ELISA assay (see the Section 2 for more details). IFN-γ and glass were used as a positive and negative control, respectively, because IFN-γ is involved in the upregulation of TGF-β1 in dermal and corneal fibroblasts [52] and glass is commonly used for evaluating cellular secretion capabilities in comparison to polymer-coated samples [53].…”