Cellulose Acetate-Based Electrospun Materials with a Variety of Biological Potentials: Antibacterial, Antifungal and Anticancer

Abstract

Novel eco-friendly fibrous materials with complex activities from cellulose acetate and cellulose acetate/polyethylene glycol (CA,PEG) containing 5-chloro-8-hydroxyquinoline as a model drug were obtained by electrospinning. Several methods, including scanning electron microscopy, X-ray diffraction analysis, ultraviolet-visible spectroscopy, water contact angle measurements, and mechanical tests, were utilized to characterize the obtained materials. The incorporation of PEG into the fibers facilitated the drug release. The amounts of the released drug from CA/5-Cl8Q and CA,PEG/5-Cl8Q were 78 ± 3.38% and 86 ± 3.02%, respectively (for 175 min). The antibacterial and antifungal activities of the obtained materials were studied. The measured zones of inhibition of CA/5-Cl8Q and CA,PEG/5-Cl8Q mats were 4.0 ± 0.18 and 4.5 ± 0.2 cm against S. aureus and around 4.0 ± 0.15 and 4.1 ± 0.22 cm against E. coli, respectively. The complete inhibition of the C. albicans growth was detected. The cytotoxicity of the obtained mats was tested toward HeLa cancer cells, SH-4 melanoma skin cells, and mouse BALB/c 3T3 fibroblasts as well. The CA/5-Cl8Q and CA,PEG/5-Cl8Q materials exhibited anticancer activity and low normal cell toxicity. Thus, the obtained fibrous materials can be suitable candidates for wound dressing applications and for application in local cancer treatment.

Innovative Fibrous Materials Loaded with 5-Nitro-8-hydroxyquinoline via Electrospinning/Electrospraying Demonstrate Antioxidant, Antimicrobial and Anticancer Activities

“…The results from in vitro release experiments demonstrate that the release of 5N was facilitated by the presence of water-soluble PVP or PVA on the surface of the fibrous material. The acquired results are consistent with our previous reports on how the presence of a water-soluble polymer in the fiber or on its surface increases the drug release rate [17,18,29,30,33].…”

“…In the present study, the following approaches were applied to fabricate innovative fibrous materials loaded with a biologically active substance-5N-with a diverse design: the one-step electrospinning of CA and 5N-in-CA fibers from a solution of CA or CA/5N (Figure 1a,b) and the electrospinning of a CA/5N solution with the simultaneous electrospraying of solution of PVA,5N or PVP,5N (Figure 1c,d). Previously, we conducted a series of preliminary experiments to determine the optimal polymer concentration for the electrospinning of cellulose acetate [30]. It was found that defect-free fibers were obtained at a cellulose acetate concentration of 10 wt% in an acetone/water (80/20 v/v) solvent system.…”

“…However, the influence of the incorporation of a biologically active substance (5N) on the fiber morphology and the biological activities of the hybrid materials also need to be studied. Figure 2 reveals the morphological structure and the distribution of the fiber diameter of the material Previously, we conducted a series of preliminary experiments to determine the optimal polymer concentration for the electrospinning of cellulose acetate [30]. It was found that defect-free fibers were obtained at a cellulose acetate concentration of 10 wt% in an acetone/water (80/20 v/v) solvent system.…”

8-Hydroxyquinoline-5-Sulfonic Acid-Containing Poly(Vinyl Alcohol)/Chitosan Electrospun Materials and Their Cu2+ and Fe3+ Complexes: Preparation, Antibacterial, Antifungal and Antitumor Activities

“…Recently, aromatic heterocyclic compounds from the group of 8-hydroxyquinoline, which have useful properties—antibacterial, antifungal, antitumor, antioxidant, anti-inflammatory and antiviral—and are characterized by low toxicity [ 31 , 32 , 33 , 34 ], have been studied intensively. Previously, we have reported on the incorporation of 8-hydroxyquinoline derivatives into electrospun materials from synthetic polymers [ 35 , 36 , 37 ], chitosan and its derivatives [ 19 , 38 ] and other natural polymers [ 39 , 40 ]. We have also reported the chemical immobilization of 5-amino-8-hydroxyquinoline onto the surface of electrospun fibers from styrene/maleic anhydride copolymers [ 41 ].…”

Facile preparation of novel antioxidant fibrous material based on natural plant extract from Portulaca oleracea and polylactide by electrospinning for biomedical applications

“…In recent years, electrospun nano-and microfibers have been widely used in the pharmaceutical field. 16 A variety of bioactive compounds and drugs including antibiotics, 17 proteins, 18 extracts, 19,20 DNA, 21 RNA 21 and anticancer drugs 22,23 have been loaded into electrospun nanofibers for disease treatment. Natural products can be obtained from four main sources: plants, animals, marine organisms and microorganisms.…”