“…Several studies have shown that actinomycetes isolated from the marine environment are metabolically active and have adapted to marine life (Bull, Stach, Ward, & Goodfellow, 2005;Lam, 2006;Valli et al, 2012). Marine actinomycetes are widely distributed in a variety of marine habitats from marine sand (Hong, Lee, Yim, Chun, & Lee, 2008), mangrove sediments (Hong et al, 2009;Hong, 2013;Azman, Othman, Velu, Cha, & Lee, 2015;Hamada et al, 2015a;Hamada et al, 2015b), seawater (Zhang, Xi, Ruan, & Huang, 2012), coastal sediments (Yu et al, 2015), and deep sea sediments (Pathom-aree et al, 2006;Bredholt et al, 2007 ;Luo et al, 2011;Zhang, Zhang, Yin, & Wang, 2015;Chen et al, 2016). The increasing number of studies on marine actinomycetes indicates that marine environment including the deep ocean, is a significant source for finding and discovering both the marine actinomycetes diversity and its secondary metabolites product.…”