Cerebral Proliferative Angiopathy (CPA)

Abstract

We report the case of a 55-year-old woman with cerebral proliferative angiopathy (CPA). Her medical history included brain surgery for small vascular lesions and suspicion of cerebral malignancy. C methionine PET (C-METH PET) demonstrated a diffusely increased uptake on the right hemisphere. Contrast-enhanced MRI documented a massive lesion with a diffuse "nidus" appearance, involving the right cerebral hemisphere (sparing the inferior frontal gyrus and the anterior frontal lobe), the brainstem, and the middle cerebellar peduncle. Pathology confirmed the diagnosis of CPA and, after radiation treatment, the patient presented with clinical and radiological response.

Cerebral Proliferative Angiopathy: A Rare Type of Cerebral Vascular Malformation

“…In one reported patient with CPA, the patient presented with clinical and radiological response after radiation therapy. 14 Like other brain vascular lesions, there may be progression of the vascular abnormality. 1,2 Whether to treat CPA patients with relatively mild symptoms and when to offer treatment remain uncertain.…”