Cetirizine, a histamine H1 receptor antagonist, decreases the first stage of orthodontic tooth movement in rats

Križnar, I.; Sprogar, Špela; Drevenšek, Martina; Vaupotič, Tomaž; Drevenšek, Gorazd

doi:10.1007/s00011-007-0615-1

Cited by 7 publications

(7 citation statements)

References 7 publications

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“…Tooth movement was increased by histamine and inhibited by cetirizine in the last period of orthodontic tooth movement [ 49 ]. In contrast, Kriznar et al (2008) observed that cetirizine inhibited tooth movement in the first period of orthodontic tooth movement [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of histamine on human periodontal ligament fibroblasts under simulated orthodontic pressure

et al. 2020

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As type-I-allergies show an increasing prevalence in the general populace, orthodontic patients may also be affected by histamine release during treatment. Human periodontal ligament fibroblasts (PDLF) are regulators of orthodontic tooth movement. However, the impact of histamine on PDLF in this regard is unknown. Therefore PDLF were incubated without or with an orthodontic compressive force of 2g/cm 2 with and without additional histamine. To assess the role of histamine-1-receptor (H1R) H1R-antagonist cetirizine was used. Expression of histamine receptors and important mediators of orthodontic tooth movement were investigated. PDLF expressed histamine receptors H1R, H2R and H4R, but not H3R. Histamine increased the expression of H1R, H2R and H4R as well as of interleukin-6, cyclooxygenase-2, and prostaglandin-E2 secretion even without pressure application and induced receptor activator of NF-kB ligand (RANKL) protein expression with unchanged osteoprotegerin secretion. These effects were not observed in presence of H1R antagonist cetirizine. By expressing histamine receptors, PDLF seem to be able to respond to fluctuating histamine levels in the periodontal tissue. Increased histamine concentration was associated with enhanced expression of proinflammatory mediators and RANKL, suggesting an inductive effect of histamine on PDLF-mediated osteoclastogenesis and orthodontic tooth movement. Since cetirizine inhibited these effects, they seem to be mainly mediated via histamine receptor H1R.

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Section: Discussionmentioning

confidence: 99%

Effects of histamine on human periodontal ligament fibroblasts under simulated orthodontic pressure

et al. 2020

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“…Two previous studies investigating the influence of cetirizine on OTM in male rats relied on digital calipers to measure the rate of OTM [17,18], while we used cone beam computed tomography (CBCT), micro-computed tomography (µCT) and software for our measurements, which allow more reliable and precise measurements [37]. OTM was quantified both as onward inclination, anterior movement and root torque of the first upper molar to address the different modalities of therapeutically induced tooth movement in orthodontics.…”

Section: Discussionmentioning

confidence: 99%

“…In previous studies a wide variety of drugs, which can be diffusely consumed even without the medical prescription at the same time of an orthodontic treatment, have already been investigated regarding a potential influence on OTM [16]; however, to date little is known about the effects of cetirizine on OTM. Merely two previous studies investigated OTM in rats with application of cetirizine [17,18]. Unfortunately, the authors overdosed cetirizine in their studies.…”

Section: Introductionmentioning

confidence: 99%

Effects of Histamine Receptor Antagonist Cetirizine on Orthodontic Tooth Movement

et al. 2020

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Many patients regularly take histamine receptor antagonists, such as cetirizine, to prevent allergic reactions, but these antiallergic drugs may have inadvertent effects on orthodontic treatment. In previous studies, histamine has been shown to modulate the sterile inflammatory reaction underlying orthodontic tooth movement. Pertinent effects of histamine antagonization via cetirizine during orthodontic treatment, however, have not been adequately investigated. We thus treated male Fischer344 rats either with tap water (control group) or cetirizine by daily oral gavage corresponding to the clinically used human dosage adjusted to the rat metabolism (0.87 mg/kg) or to a previously published high dosage of cetirizine (3 mg/kg). Experimental anterior movement of the first upper left molar was induced by insertion of a nickel-titanium (NiTi) coil spring (0.25 N) between the molar and the upper incisors. Cone-beam computed tomography (CBCT), micro-computed tomography (µCT) images, as well as histological hematoxylin-eosin (HE), and tartrate-resistant acid phosphatase (TRAP) stainings were used to assess the extent of tooth movement, cranial growth, periodontal bone loss, root resorptions, and osteoclast activity in the periodontal ligament. Both investigated cetirizine dosages had no impact on the weight gain of the animals and, thus, animal welfare. Neither the extent of tooth movement, nor cranial growth, nor root resorption, nor periodontal bone loss were significantly influenced by the cetirizine dosages investigated. We, thus, conclude that histamine receptor antagonist cetirizine can be used during orthodontic treatment to prevent allergic reactions without clinically relevant side effects on orthodontic tooth movement.

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“…The rate of orthodontic tooth movement was lowered after the administration of famotidine (Sprogar et al, 2008), whereas the effect of cetirizine was inconsistent (Kriznar et al, 2008; Meh et al, 2008). Excessive histamine levels trigger bone resorptive processes (Barete et al, 2010).…”

Section: Antihistaminesmentioning

confidence: 99%

Medication and orthodontic tooth movement

Makrygiannakis¹,

Kaklamanos

Athanasiou

2019

J Orthod

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As any pharmaceutical substance may influence the events associated with orthodontic tooth movement, it is of importance for the clinician to be able to recognize any prospective patient’s history and patterns of medicinal consumption. This review presents the effects of various commonly prescribed medications on the rate of orthodontic tooth movement. The article concludes that it remains, to a degree, unclear which types of medication may have a clinically significant effect in everyday clinical scenarios. However, since both prescription and over-the-counter medication use have recently increased significantly among all age groups, good practice suggests that it is important to identify patients consuming medications and consider the possible implications in orthodontic therapy.

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Cetirizine, a histamine H1 receptor antagonist, decreases the first stage of orthodontic tooth movement in rats

Cited by 7 publications

References 7 publications

Effects of histamine on human periodontal ligament fibroblasts under simulated orthodontic pressure

Effects of histamine on human periodontal ligament fibroblasts under simulated orthodontic pressure

Effects of Histamine Receptor Antagonist Cetirizine on Orthodontic Tooth Movement

Medication and orthodontic tooth movement

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