Changes in red blood cell glutathione and gliatathione-dependent enzymes on long-term treatment with captopril and enalapril

Golik, Ahuva; Weissgarten, Joshua; Evans, Sandra; Cohen, Natan; Modai, David; Cotariu, Dita

doi:10.1016/0009-8981(95)06121-3

Cited by 5 publications

(1 citation statement)

References 9 publications

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“…Neither GSH nor GSH/GSSG values changed in SHRs, in line with a previous report [27], indicating a good blood antioxidant barrier against the burst of radicals associated with hypertension. Although the captopril diet lowered blood pressure, it did not modify GSH-GSSG balance, as already reported in humans [28]. In contrast, the TM diet increased the GSH/GSSG ratio, suggesting that its antihypertensive effect could be linked to the reduction in GSSG in red blood cells or vice versa.…”

Section: Plos Onesupporting

confidence: 74%

Antihypertensive, cardio- and neuro-protective effects of Tenebrio molitor (Coleoptera: Tenebrionidae) defatted larvae in spontaneously hypertensive rats

et al. 2020

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In pre-hypertension, moderate control of blood pressure (BP) can be obtained by a nutritional approach. The effects of a diet enriched with defatted larvae of the mealworm Tenebrio molitor (Coleoptera: Tenebrionidae) (TM) endowed with ACE inhibitory activity was studied in both spontaneously hypertensive rats (SHR) and in the age-matched normotensive Wistar Kyoto strain. These were fed for 4 weeks with standard laboratory rodent chow supplemented with or without TM or captopril. In SHR, the TM diet caused a significant reduction in BP, heart rate and coronary perfusion pressure, as well as an increase in red blood cell glutathione/glutathione disulphide ratio. Rat brain slices of SHR were more resistant to oxidative stress and contained lower levels of inflammatory cytokines, while vascular and liver enzyme-activities were not affected. These results suggest that TM can be considered a new functional food that can lower BP in vivo and thus control cardiovascular-associated risk factors such as hypertension.

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Section: Plos Onesupporting

confidence: 74%