Changes in Serum Biochemical Parameters and Lipid Profile in Normal and STZ Induced Diabetic Rats With the Administration of Ethanolic Extract of Polyalthia Cerasoides Stem Bark

Abstract

The present study was conducted to determine the changes in serum biochemical parameters and lipid profile by oral administration of ethanolic extract of Polyalthia cerasoides stem bark (PcEE 400 mg/kg b. wt) in streptozotocin (45 mg/kg b. wt) induced diabetic rats. Albino rats of weighing between 200-230 g were induced with single dose of streptozotocin (dissolved in 0.1 M ice cold citrate buffer (pH = 4.5) at a dose 45 mg/kg b. wt). Diabetes was confirmed after 48 h in streptozotocin induced rats showing fasting blood glucose levels ≥ 250 mg/dl. The rats were randomly divided into five groups (n = 6). Group I and II (normal and diabetic controls), Group III (normal rats fed with 400 mg of PcEE), Group IV (diabetic rats fed with 400 mg of PcEE), Group V (diabetic rats fed with 20 mg of Glibinclamide). After 21 days animals were sacrificed and blood samples were collected for biochemical analysis. The results showed that the extract significantly (p < 0.05) reduced serum ALT, AST and ALP levels when compared to the diabetic control. The urea and creatinine levels are also controlled significantly (P <0.05). Similarly TC, LDL, VLDL-cholesterol, TG and total lipids of serum were significantly (P <0.05) decreased in streptozotocin induced diabetic rats but HDL-cholesterol levels remained unchanged when compared to the diabetic control animals. The results clearly suggested that the extract has the ability to retain the altered biochemical parameters as normal in diabetic animals and tt was effective as glibinclamide treated animals. Hence the study reveals the therapeutic use of PcEE on diabetes and its complications

&lt;i&gt;Brillantasia patula&lt;/i&gt; Aqueous Leaf Extract Averts Hyperglycermia, Lipid Peroxidation, and Alterations in Hematological Parameters in Alloxan-Induced Diabetic Rats

“…The reduction in urea concentration observed in all the treated groups may probably be as a result of improvement of renal function by the administration of the aqueous extract of the leaf. A similar observation has been reported [32]. The decrease in creatinine concentration observed in some treated groups could be attributed to the effectiveness of the restoration of the impaired renal function by the presence of bioactive compounds extract [33,34].…”

Antioxidant properties of polyphenol glycoside catalyzed by transglycosylation reaction of cyclodextrin glucanotransferase derived fromTrichoderma viride

“…One‐way ANOVA test was used and the results of the analysis were expressed as a mean ± standard deviation followed by Tukey B test. p Value < .05 was considered as significant (Bhargavi, Josthna, & Naidu, ).…”

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“…This may be due to the cellular damage to liver caused by STZ which leads to leakage of enzymes from cytosol into the bloodstream. [37] In a similar study, Sangeetha et al had reported an increase in the activity of serum AST, ALT, and ALP after the administration of STZ to the rats. [38] The activity of serum AST, ALT and ALP was found to be significantly decreased in rats when compared with diabetic rats.…”