Changes in the Antibacterial Activity of Benzylpenicillin Exposed to a Pulsed High-Intensity Magnetic Field

Glushchenkov, V. A.; Vasilyeva, T. I.; Purigin, P. P.; Belyaeva, I. А.; Rodenko, Natalia A.; Madyarova, A. K.; Jusupov, R.J.

doi:10.1134/s0006350919020088

Cited by 5 publications

(3 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ref. [16] suggests that pulsed magnetic field can cause conformational changes in the hydration shell of antibiotic molecules, which results in the changes of its activity. We believe that in the interaction between laser radiation and protein water solutions (which includes blood plasma), it is equally important to consider the role of the macromolecule hydration shell as well as the ability of the macromolecules themselves to make associates [17], which affects its functional activity.…”

Section: Discussionmentioning

confidence: 99%

Study into Dynamics of Structural Changes Occurring in Blood Plasma under Laser Radiation

Neupokoeva

Gavrilov

Yakutin

2021

J-BPE

View full text Add to dashboard Cite

This paper focuses on studying the impact of laser irradiation ( = 532 nm, power 15 mW) on human blood plasma. The structural changes in plasma were controlled by the crystallographic method with the mean crystallogram segment size as a numerical evaluation. In addition, the structural changes were explored by processing the speckle patterns obtained during laser radiation passes through plasma. Exposure to laser radiation of  = 532 nm for 20 min resulted in the 30% reduced the crystallogram characteristic size with the dynamics of the structural changes coinciding with the dynamics discovered by speckle patterns processing. The crystallographic method revealed that laser induced structural changes in plasma remain for 24–36 h after exposure.

show abstract

Section: Discussionmentioning

confidence: 99%

Study into Dynamics of Structural Changes Occurring in Blood Plasma under Laser Radiation

Neupokoeva

Gavrilov

Yakutin

2021

J-BPE

View full text Add to dashboard Cite

show abstract

“…In our previous work [8], we found a 12-24% increase in the antibacterial effect of benzylpenicillin sodium salt processed by a pulsed magnetic field with the field intensity ranging from 0.09 × 10 6 A/m to 1.23 × 10 6 А/m at the frequency f = 40 kHz (single-turn inductor) and a number of pulses n = 1. The pulsed magnetic field action was carried out on a powdered pharmaceutical preparation.…”

Section: Introductionmentioning

confidence: 91%

Changes in the Structure of the Benzylpenicillin Sodium Salt Molecule under the Pulsed Magnetic Field

Rodenko

Zhukova

Vasilieva

et al. 2021

J-BPE

View full text Add to dashboard Cite

The study aims at the Fourier spectra of an antibiotic exposed to a high-intensity pulsed magnetic field. The applied frequency was f = 40 kHz, with a number of pulses n = 1, at intensities of the pulsed magnetic field H = 0.09 × 106 А/m, Н = 0.50 × 106 А/m, Н = 0.82 × 106 А/m. It was assumed that under the conditions of the pulsed magnetic field there might be a change in the structure of the drug molecule. The research has revealed that an increase in the pulsed magnetic field power leads first to a decrease in the intensity of the band in the Fourier spectrum, and then to its increase. In addition, changes were recorded in the amide group of benzylpenicillin sodium salt molecules depending on the intensity of the pulsed magnetic field applied to the antibiotic.

show abstract

“…Herein, we propose benzylpenicillin sodium salt (b-PEN) for use in TENG devices as an energy-harvesting biomaterial. We demonstrate that b-PEN is a tribopositive material owing to its excellent electron-donating capability, which is attributed to the existence of lone electron pairs on its sulfur atom, carbonyl, and amide functional groups (-NH-CO-) in the lactam ring [50,51]. The proposed TENG device was assembled using the b-PEN as the tribopositive layer and PTFE as the tribonegative layer.…”

Section: Introductionmentioning

confidence: 97%

Antibiotic-Powered Energy Harvesting: Introducing Benzylpenicillin as an Efficient Tribopositive Material for Triboelectric Nanogenerators

Nauman,

Ameen,

Kim

2023

Nanomaterials

View full text Add to dashboard Cite

The pursuit of enhancing the performance of triboelectric nanogenerators (TENGs) has led to the exploration of new materials with efficient charge-generating capabilities. Herein, we propose benzylpenicillin sodium salt (b-PEN) as a candidate biomaterial for the tribopositive layer owing to its superior electron-donating capability via the lone pairs of electrons on its sulfur atom, carbonyl, and amino functional groups. The proposed b-PEN TENG device exhibits promising electrical performance with an open-circuit voltage of 185 V, a short-circuit current of 4.52 µA, and a maximum power density of 72 µW/cm2 under force applied by a pneumatic air cylinder at 5 Hz. The biomechanical energy-harvesting capabilities of the b-PEN TENG device are demonstrated by actuating it with finger, hand, and foot movements. Moreover, the proposed TENG device is utilized to charge capacitors and power light-emitting diodes by scavenging the externally applied mechanical energy. This outstanding electrical performance makes b-PEN a promising tribopositive material.

show abstract

Changes in the Antibacterial Activity of Benzylpenicillin Exposed to a Pulsed High-Intensity Magnetic Field

Cited by 5 publications

References 5 publications

Study into Dynamics of Structural Changes Occurring in Blood Plasma under Laser Radiation

Study into Dynamics of Structural Changes Occurring in Blood Plasma under Laser Radiation

Changes in the Structure of the Benzylpenicillin Sodium Salt Molecule under the Pulsed Magnetic Field

Antibiotic-Powered Energy Harvesting: Introducing Benzylpenicillin as an Efficient Tribopositive Material for Triboelectric Nanogenerators

Contact Info

Product

Resources

About