Characteristic of Nasopharyngeal Carsinoma in Aceh 2016-2017

Abstract

Introduction
 Nasopharyngeal carcinoma is among five major malignancies in Indonesia and the primary malignant tumor in men. Among all head and neck (H&N) cancers, nasopharyngeal carcinoma (NPC) is endemic in certain regions of the world, especially in Southeast Asia, and has a poor prognosis. In Indonesia, the recorded mean prevalence is 13 000 yearly new NPC cases, but otherwise little is documented on NPC in Indonesia.
 Objectives
 We collected all cases of nasopharyngeal carcinoma diagnosed by histopathological examination during the period of 2016-2017 from archives of the registry in the Ear, Nose, and Throat department and Patologi Anatomy laboratory Dr. Zainoel Abidin General Hospital. We did this research to presenting the basic data of NPC in Aceh according to gender, age, geographic site and WHO histopathology criteria.
 Method
 All the data we counted by using Microsoft Excel 2016 by grouping it according to the variable that we want to grade. We made it into a table and graphic presentation to explain each item of the variable.
 Result
 Here, in Aceh, we reported 46 cases in the year 2016 and 26 cases in the year 2017, a total of 72 patients during 2 years. We studied NPC incidence in Aceh among all H&N cancer cases focusing on age, gender, the ethnic background, and the disease histopathology. In this study population, from a total of 72 patient we found 44 male (61.1%) and 28 female (38.9%), with a male to female ratio is 1.57:1. According to the geographic site, NPC in Aceh was the most endemic in the Banda Aceh population (15.3%) followed by Southwest Aceh (12.5%) as a second one. From the age range, NPC most frequent to affect patients at the age range 41-60 years (44.44%), besides that we found 8 (11.11%) cases NPC in Aceh at the age 0- 20 years with 13 years old patient was the younger one. Here, we found that Undifferentiated NPC is the most frequent histological type (44.4%). We continued the study by analyzed NPC patient according to WHO criteria, type I WHO most frequent from the Great Aceh. Type II and Type III WHO we found most frequent from Banda Aceh.
 Conclusion: Our data NPC incidence did not differ significantly among the literature. Mostly NPC patients over the world at the old adult age, even all of the age range can be affected by NPC. There are similar histopathological features results here compare to the Southeast Asian country.

Relationship between Primary Tumors of Nasopharyngeal Carcinoma with the Degree of Conductive Hearing Loss in Dr. Mohammad Hoesin Hospital Palembang

“…This explains slightly that NPC is influenced by gender. 4,5,6 Based on this study subjects with WHO histopathology type 1 are least found, which is 2.4%. (33.6%) followed by T4 in 36 patients (25.2%).…”

“…This may be due to ignorance of the presence of a mass in the nasopharynx area so that resulting the mass has occurred on both sides. 5,6,7,8 The most widely chief complaint clinical symptoms that make patients come for treatment such as a lump in the neck, hearing loss, nose bleeds, double vision and others. Based on clinical symptoms in NPC patients in this study the most chief complaints were lumped in the neck, which is 61.9%, followed by double vision and nose bleeds in 9.5%, tinnitus, headaches and nasal obstruction with a proportion of 4.8% each.…”