Chemical constituents and pharmacology of Aristolochi species

Wu, Tong; Amooru, G Damu; Su, Chung‐Ren; Kuo, Ping Chung

doi:10.1016/s1572-5995(05)80071-7

Cited by 9 publications

(2 citation statements)

References 245 publications

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“…Compounds 1 and 2 are benzyltetrahydroisoquinoline alkaloids, which did not demonstrate antituberculosis activity in this study ( Table 1 ). Other alkaloids of this type also have been isolated in Aristolochia constricita , and these demonstrated a significant decrease in the electrically induced contraction, with acetylcholine and guinea pig ileum-isolated histamine [ 14 ], while compounds 3 and 4 are 5-nitro-2 H -benzo[h]chromenones (presumably derived from aristolochic acid) [ 15 ], popularly known as “tariacuripironas”. To our knowledge, there are no reports in the literature on biological evaluations of this type of compounds; we only found the description of strong mutagenic activity for 9-methoxy-tariacuripyrone ( 4 ) against TA98, TA100, and YG of Salmonella typhimurium strains [ 16 ].…”

Section: Resultsmentioning

confidence: 99%

Antibacterial Activity of Aristolochia brevipes against Multidrug-Resistant Mycobacterium tuberculosis

Navarro-García¹,

Luna-Herrera²,

Rojas-Bribiesca³

et al. 2011

Molecules

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The increased incidence of Multidrug-Resistant Mycobacterium tuberculosis (MDR-MT) requires the search for alternative antimycobacterial drugs. The main aim of this study was to evaluate the dichloromethane extract from Aristolochia brevipes (Rhizoma) and the compounds isolated from this extract against several mycobacterial strains, sensitive, resistant (monoresistant), and clinical isolates (multidrug-resistant), using the alamarBlue™ microassay. The extract was fractionated by column chromatography, yielding the following eight major compounds: (1) 6α-7-dehydro-N-formylnornantenine; (2) E/Z-N-formylnornantenine; (3) 7,9-dimethoxytariacuripyrone; (4) 9-methoxy-tariacuripyrone; (5) aristololactam I; (6) β-sitosterol; (7) stigmasterol; and (8) 3-hydroxy-α-terpineol. The structures of these compounds were elucidated by 1H- and 13C- (1D and 2D) Nuclear Magnetic Resonance (NMR) spectroscopy. This study demonstrates that the dichloromethane extract (rhizome) of A. brevipes possesses strong in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv (Minimum Inhibitory Concentration value [MIC], 12.5 µg/mL). The most active compound against all mycobacterial strains tested was the compound aristolactam I (5), with MIC values ranging between 12.5 and 25 µg/mL. To our knowledge, this the first report of antimycobacterial activity in this plant.

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Section: Resultsmentioning

confidence: 99%

Antibacterial Activity of Aristolochia brevipes against Multidrug-Resistant Mycobacterium tuberculosis

Navarro-García¹,

Luna-Herrera²,

Rojas-Bribiesca³

et al. 2011

Molecules

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“…The whole plant was used as a purgative, antipyretic, and antiinflammatory. It also possesses a potent antiallergic activity (Tian-Shung et al 2005).…”

Section: Introductionmentioning

confidence: 99%

PHYTOCHEMICALS: EXTRACTION, ISOLATION & IDENTIFICATION OF BIOACTIVE COMPOUNDS FROM ARISTOLOCHIA BRACTEOLATE

Nasser

2020

IJALSR

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Objective:To isolate, analyze and identify the phytochemical compositions from Aristolochia bracteolate leaves. Methods: Preliminary phytochemical analysis for four active constituents, extracted from powdered leaves with different solvents by using Soxhlet apparatus and carried out by different chromatographic techniques. The phytochemical characterizations were evaluated by NMR & MS. Results: This species exhibited & Identified four compounds representing 2.0 % of the total phytochemical composition. The Preliminary phytochemical analysis confirmed the presence of Hydroxystigmast-5-en-7-one, Oleanonic acid, 5,7,4ʹ-trihydroxy-3,8-dimethoxyflavone & 7,9-dimethoxytariacuripyrone. All of them are report for first time from this Spp. Conclusions: From this study, can be concluded that report for the first time from Aristolochia bracteolate leaves, identified 4 pure chemical compounds, by analysis using various physical & spectral techniques.

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Cytotoxic effect of Myrtus communis, Aristolochia longa, and Calycotome spinosa on human erythrocyte cells

Gadouche

Zidane

Zerrouki

et al. 2021

Foods and Raw Materials

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Introduction. Myrtus communis, Aristolochia longa, and Calycotome spinosa are medicinal plants frequently used in Algeria. Some plants can cause a fragility of the erythrocyte membrane and lead to hemolysis. Therefore, we aimed to study the cytotoxicity of aqueous extracts from the aerial part of these species against red blood cells. Study objects and methods. The hemolytic effect was determined spectrophotometrically by incubating an erythrocyte solution with different concentrations of the aqueous extracts (25, 50, 100, and 200 mg/mL) at 37°C during one hour. In addition, we performed phytochemical screening and measured the contents of polyphenols and flavonoids. Results and discussion. After one hour of incubation of human red blood cells with the aqueous extracts at different concentrations, the hemolysis percentage showed a significant leak of hemoglobin with A. longa (68.75 ± 6.11%; 200 mg/mL), the most toxic extract followed by C. spinosa (34.86 ± 5.06%; 200 mg/mL). In contrast, M. communis showed very low cytotoxicity (20.13 ± 3.11%; 200 mg/mL). Conclusion. These plants are sources of a wide range of bioactive compounds but their use in traditional medicine must be adapted to avoid any toxic effect.

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Chemical constituents and pharmacology of Aristolochi species

Cited by 9 publications

References 245 publications

Antibacterial Activity of Aristolochia brevipes against Multidrug-Resistant Mycobacterium tuberculosis

Antibacterial Activity of Aristolochia brevipes against Multidrug-Resistant Mycobacterium tuberculosis

PHYTOCHEMICALS: EXTRACTION, ISOLATION & IDENTIFICATION OF BIOACTIVE COMPOUNDS FROM ARISTOLOCHIA BRACTEOLATE

Cytotoxic effect of Myrtus communis, Aristolochia longa, and Calycotome spinosa on human erythrocyte cells

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