Chemical constituents of Salacia elliptica (Celastraceae)

Duarte, Lucienir Pains; Figueiredo, Rute Cunha; Sousa, Grasiely Faria de; Soares, Débora Barbosa da Silva; Rodrigues, Salomão Bento Vasconcelos; Silva, Fernando César; Silva, Grácia Divina de Fátima; Filho, Sidney Augusto Vieira

doi:10.1590/s0100-40422010000400026

Cited by 16 publications

(14 citation statements)

References 23 publications

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“…This fact could be related to the higher liposolubility of this pentacyclic triterpene, leading to a higher ability of crossing the host cell membrane. The trypanocidal activity of triterpenes has previously been investigated (Abe et al 2002;Duarte et al 2002;Rosas et al 2007), and structure activity relationship studies revealed that the presence of the carboxyl group at C-17 is required for activity against T. cruzi (Cunha et al 2006;Leite et al 2006).…”

Section: Resultsmentioning

confidence: 99%

Croton cajucara crude extract and isolated terpenes: activity on Trypanosoma cruzi

et al. 2010

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Croton cajucara is a plant found in the Amazon region and is known for its medicinal properties. The effects of the methanolic extract of the stem bark of C. cajucara (MCC) and of the isolated terpenes, trans-dehydrocrotonin (t-DCTN) and acetyl aleuritolic acid (AAA), were investigated using four isolates of Trypanosoma cruzi. In assays with trypomastigotes, the extract was more active than the isolated compounds, presenting IC(50) in the range of 10 to 50 μg/mL. The trypanocidal effect of MCC, AAA and benznidazole was significantly higher in the GLT291 and C45 strains, which were recently isolated from wild animals. MCC and AAA caused a dose-dependent inhibition of epimastigote proliferation. In assays using intracellular amastigotes, AAA and MCC reduced the percent of infection and the endocytic index after 96 h of treatment, at concentrations that were non-toxic to the host cells. MCC inhibited the trypanothione reductase pathway in both epimastigotes and trypomastigotes of all the subpopulations. The absence of AAA activity on the trypanothione reductase pathway in epimastigotes of Dm28c suggests heterogeneity of the biochemical profile between this clone and the three strains. Epimastigotes and trypomastigotes (GLT291) were treated for 24 h with MCC or AAA, and both induced alterations of the plasma membrane, while AAA-treated epimastigotes also displayed mitochondrial damage.

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Section: Resultsmentioning

confidence: 99%

Croton cajucara crude extract and isolated terpenes: activity on Trypanosoma cruzi

et al. 2010

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“…The spectral data of all these compounds ( Figure 1) were in agreement with the previously published data, thereby allowing for identification of 16β-hydroxylupane-1,20(29)-dien-3-one (1) (Wei et al 2008), (3β)-3-hydroxyolean-12-en-28-oic acid (2) (Xiao-Qiang et al 2008;Geraldo et al 2008), 3β-hydroxy-olean-5,12-dien-28-oic acid (3) (Choudhary et al 2007;Zhang et al 1993), daucosterol (4) (Duarte et al 2010;Sultana et al 2010;Bayoumi et al 2010), 3-O-β-d-glucopyranosyl-stigmasta-5,11(12)-diene (5) and chlorogenic acid (6) (Kusaura et al 2010 3 OD, showed characteristic signals of two methyl groups at 1.15 ppm (3H, t, J = 7.0 Hz) and 2.57 ppm (3H, br s). Two methoxy groups were observed at 3.21 ppm (6H, br s) and one at 3.70 ppm (3H, br s).…”

Section: Discussionmentioning

confidence: 99%

In vitroantileishmanial, antiplasmodial and cytotoxic activities of a new ventiloquinone and five known triterpenes fromParinari excelsa

Attioua¹,

Yeo

Lagnika

et al. 2012

Pharmaceutical Biology

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“…In Amazon, there are several plant species bearing medicinal properties (OSAKADA, 2009), including the species belonging to the Celastraceae family, composed by 98 genera and roughly 1264 species (FONSECA ET AL., 2007;LORENZI & MATOS, 2008;OLIVEIRA et al, 2012), distributed all over the world, particularly in the tropical and subtropical regions, including the north of Africa, South America and Asia (SPIVEY et al, 2002;DUARTE et al, 2010;HURTADO, 2013;MOHAMED & PERWEZ, 2014).…”

Section: Introductionmentioning

confidence: 99%

Microbiological evaluation of isolated compounds from the bark of Maytenus guianensis Klotzsch ex Reissek (Celastraceae)

Lima

Hurtado

Meneguetti

et al. 2016

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Maytenus guianensis Klotzsch ex Reissek is a brazilian Amazon plant widely used in tradicional medicine to treat malaria, leishmaniasis and cancer. Due to the increasing number of resistant strains of microorganisms to known antimicrobial substances, various extracts of medicinal plants are being assayed with the purpose of developing new compounds with antimicrobial activities. Thus, the present work aimed to evaluate the biological potential of isolated substances of the bark of M. guianensis on bacteria. The barks were collected at the Reserva Florestal Adolpho Ducke, in Manaus-AM. After, they were dried and grinded, being subjected to Soxhlet extraction with different solvants according to their polarity degree. The isolated substances were diluted with DMSO 2 %, and for the evaluation of the antibacterial potential, the agar well diffusion technique was used. The design was totally randomized with two replicas per treatment. The evaluation consisted on measuring bacteria colonial growth after 24 hours of the beginning of the experiment. The results obtained from the isolated substances of M. guianensis presented inhibitory effect against at least four out of the five bacteria tested, where satisfactory inhibition halos were noted. The results highlight the antimicrobial potential of this plant, which may be promising for the development of new drugs.

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Chemical constituents of Salacia elliptica (Celastraceae)

Cited by 16 publications

References 23 publications

Croton cajucara crude extract and isolated terpenes: activity on Trypanosoma cruzi

Croton cajucara crude extract and isolated terpenes: activity on Trypanosoma cruzi

In vitroantileishmanial, antiplasmodial and cytotoxic activities of a new ventiloquinone and five known triterpenes fromParinari excelsa

Microbiological evaluation of isolated compounds from the bark of Maytenus guianensis Klotzsch ex Reissek (Celastraceae)

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