ChemInform Abstract: Synthesis and Biological Activities of Meribendan and Related Heterocyclic Benzimidazolo‐pyridazinones.

Abstract

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Evaluation of Biological Activity of a Diazocine Derivative against Heart Failure Using an Ischemia-Reperfusion Injury Model

“…For example, the synthesis of 4-(5H-Imidazo[4,5-c]pyridazin-6-yl)-3-methoxy-thiobenzoic acid S-methyl ester from Benzene-1,2-diamine with positive inotropic activity on isolated paced guinea pig papillary muscle 5 . In addition, a study showed the preparation of meribendan (5-methyl-6[2-(3-pyrazolyl)-5-benzimidazoyl]-2,3,4,5-tetrahydro-pyridazin-3-one) through reaction of pyrazole-3-carboxaldehyde with cyanuric chloride and their positive inotropic activity using a guinea pig heart model 6 . Other study display the reaction of (3-phenylpyridin-2-yl)methylamine with dichloroacetaldehyde to form the compound methyl 3-methyl-8-phenylimidazo[1,5-a]pyridine-1-carboxylate; it is noteworthy that this compound produce positive inotropic activity in a papillary cat muscle model 7 .…”

Efficient and Uncatalyzed Synthesis of Highly Functionalized New Symmetrical Indeno[1,2‐b]pyrroles via a One‐Pot Four‐Component Reaction

“…Furthermore, poly‐functionalized pyrroles as scaffolds show enormous significance in material science . Besides, they have been applied as anti‐inflammatory, antitumor, antioxidants, antibacterial and antifungal agents …”

Solvent‐free synthesis of pyrrole derivatives

“…In addition, polysubstituted pyrroles are molecular frameworks having immense importance in material science [5]. They have also been used as antioxidants, antibacterial, ionotropic, antitumor, anti‐inflammatory, and antifungal agents [6–11]. Moreover, they are a highly versatile class of intermediates in the synthesis of natural products and in heterocyclic chemistry [12].…”