China Must Reduce Its Antibiotic Use

Ying, Guang‐Guo; He, Liang-Ying; Ying, Andrew; Zhang, Qianqian; Liu, You-Sheng; Zhao, Jian‐Liang

doi:10.1021/acs.est.6b06424

Cited by 152 publications

(55 citation statements)

References 5 publications

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“…The high prevalence of gentamicin resistance in Campylobacter found in this study is consistent with previous findings in China. According to the antimicrobial usage data collected in 2013, the total consumption of antibiotics was 162,000 tons in China, of which 83,200 tons was used in animals (20,21). Additionally, antimicrobial usage records suggested that aminoglycoside agents, such as amikacin and neomycin, were commonly used to prevent and control bacterial diseases in food-producing animals in China (3).…”

Section: Resultsmentioning

confidence: 99%

High Prevalence and Predominance of the aph(2″)-If Gene Conferring Aminoglycoside Resistance in Campylobacter

Yao

Liu

Wang

et al. 2017

Antimicrob Agents Chemother

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Campylobacter is a major foodborne pathogen, and previous studies revealed that Campylobacter isolates from food-producing animals are increasingly resistant to gentamicin in China. The molecular epidemiology and genetic mechanisms responsible for gentamicin resistance in China have not been well understood. In this study, 607 Campylobacter isolates of chicken and swine origins collected in 2014 were analyzed, revealing that 15.6% (25/160) of the Campylobacter jejuni isolates and 79.9% (357/447) of the Campylobacter coli isolates were resistant to gentamicin. PCR detection of the gentamicin resistance genes indicated that aph(2Љ)-If was more prevalent than the previously identified aacA/aphD gene and has become the dominant gentamicin resistance determinant in Campylobacter. Transformation and wholegenome sequencing as well as long-range PCR discovered that aph(2Љ)-If was located on a chromosomal segment inserted between two conserved genes, Cj0299 and panB. Cloning of aph(2Љ)-If into gentamicin-susceptible C. jejuni NCTC 11168 confirmed its function in conferring high-level resistance to gentamicin and kanamycin. Molecular typing by pulsed-field gel electrophoresis suggested that both regional expansion of a particular clone and horizontal transmission were involved in the dissemination of the aph(2Љ)-If gene in Campylobacter. To our knowledge, this is the first report describing the high prevalence of a chromosomally encoded aph(2Љ)-If gene in Campylobacter. The high prevalence and predominance of this gene might be driven by the use of aminoglycoside antibiotics in food animal production in China and potentially compromise the usefulness of gentamicin as a therapeutic agent for Campylobacter-associated systemic infection.

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Section: Resultsmentioning

confidence: 99%

High Prevalence and Predominance of the aph(2″)-If Gene Conferring Aminoglycoside Resistance in Campylobacter

Yao

Liu

Wang

et al. 2017

Antimicrob Agents Chemother

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“…Second, antimicrobial drugs are widely used in hog production in China (Krishnasamy, Otte, and Silbergeld 2015). While China has issued a series of regulations for antimicrobial use in the livestock industry since 2001, enforcement of these is not strict (Ying et al 2017). Lin et al (2010) sampled 485 pork products from supermarkets and restaurants in Guangzhou and found that only 76% met the standard for antibiotic residues.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial use and farm size in China’s Shandong province

Li¹,

Liu²,

Hoffmann³

et al. 2020

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“…It has been reported that the usage of antibiotics in China approximately reached 162000 tons in 2013. 1,2 Sulfonamides, one of the widely applied groups of antibiotics, are used in anti-inflammatory, antiviral and antibacterial medicines. [3][4][5] As known to us, p-amino benzenesulfonamides can inhibit infections, but its chronicity and difficult degradation leads to toxicity.…”

Section: Introductionmentioning

confidence: 99%

Optical Recognition of Sulfamethoxazole by a Colored Chiral Nematic Imprinted Film

et al. 2019

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In this article, an alterable structural color in the reflected light of a chiral nematic imprinted film was fabricated. Biotemplate nanocrystalline celluloses were applied as structural oriented templates. Selectivity of the sensor was endowed by the molecular imprinting process which applied sulfamethoxazoles (SMXs) as template molecules, urea and phenol as double functional monomers, and formaldehyde as cross-linkers. The sensor exhibited a chiral nematic blue mesoporous structure, which could selectively recognize SMXs on account of the abundant predetermined rebinding sites. Once SMXs were detected, the sensor showed a visible color variance from blue to yellow and the sensitive concentration range was from 3.9 × 10-3 to 3.9 mmol L-1. Both quantitative analyses, selective testing and recycling performance of the sensor were demonstrated. This optical response to SMXs can provide a portable, low-cost and easy-to-use strategy for the convenient detection of SMXs.

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China Must Reduce Its Antibiotic Use

Cited by 152 publications

References 5 publications

High Prevalence and Predominance of the aph(2″)-If Gene Conferring Aminoglycoside Resistance in Campylobacter

High Prevalence and Predominance of the aph(2″)-If Gene Conferring Aminoglycoside Resistance in Campylobacter

Antimicrobial use and farm size in China’s Shandong province

Optical Recognition of Sulfamethoxazole by a Colored Chiral Nematic Imprinted Film

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