Chinese herbal medicine for premature ovarian insufficiency

Abstract

Background: Premature ovarian insufficiency (POI) is the loss of function of the ovaries before age 40. Chinese herbal medicine (CHM) has been treating POI for long time. Therefore, we conduct this study to assess the efficacy and safety of CHM for POI. Methods: Seven databases will be searched from inception to December 31, 2018: PubMed, Embase, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI), China Biology Medicine disc (CBM), WanFang Database, and Chongqing Chinese Scientific Journal Database (CQVIP). Randomized controlled trials that used CHM will be included. Two reviewers will independently complete the study selection, data extraction, and study quality assessment according to Cochrane Collaboration. All the data will be analyzed using Review Manage 5.3 software. Results: This study will generate a comprehensive summary on effectiveness and safety of CHM for POI. Conclusion: This study may be beneficial to health policymakers, clinicians, and patients with regard to the use of CHM in POI treatment. Trial registration number: PROSPERO CRD 42019144629.

Female germline stem cells: aging and anti-aging

“…As a result, numerous patients are switching to complementary and alternate medicine (CAM). As one major branch of CAM, traditional Chinese medicine (TCM), regarded as having less side effects, has been extensively used in China and in other countries to treat ovarian aging [106][107][108]. According TCM theory, ovarian aging diseases i are related to kidney, liver, spleen, heart, lung and other zang-organs' mulfunction(we need to declare specifically that in the TCM theory, "kidney, liver, spleen, heart, lung"are not as same as the cencepts of morden medicine), espectially uterus mulfunction; dysregulation of thorough fare and conception vessels is the key link of ovarian aging pathogenesis.The etiology and pathogenesis concludes cold evil invasion, qi and blood deficiency, liver stagnation and qi stagnation, phlegm and blood stasis block, which eventually lead to meridian block, stagnation of qi and blood activities, zang-fu dysfunction.…”

The Treatment of Complementary and Alternative Medicine on Premature Ovarian Failure

“…Herbal medicine is one of the most common forms of traditional Chinese medicine (TCM) and has always been considered the best among the treatment methods in Chinese medicine. Studies have shown that CHM is effective in treating POF [ 28 ]. There are numerous reports in the Chinese literature about the treatment of POF with herbal remedies, but only abstracts are available in English.…”

“…Herbal medicine is one of the most common forms of traditional Chinese medicine (TCM) and has always been considered the best among the treatment methods in Chinese medicine. Studies have shown that CHM is effective in treating POF [28].…”