Choline and DHA in Maternal and Infant Nutrition: Synergistic Implications in Brain and Eye Health

Mun, Jonathan G.; Legette, LeeCole L.; Ikonte, Chioma J.; Mitmesser, Susan Hazels

doi:10.3390/nu11051125

Cited by 59 publications

(45 citation statements)

References 134 publications

(162 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the increase in obesity during pregnancy and breastfeeding as well as gestational diabetes, among other pathologies observed during the last decade, could alter the transport of LCPUFA to the placenta leading to a decrease in LCPUFA (mainly DHA) availability [ 72 , 74 , 75 ]. Currently, the potential impact in brain development of the transport of LCPUFA to the fetus or to the infant in maternal obesity and/or gestational diabetes, is a main study objective [ 71 , 75 ], findings that justify LCPUFA intake recommendations during pregnancy and lactation [ 71 , 75 , 76 ].…”

Section: Dha and Aa During Pregnancy And Breast Milk Periodmentioning

confidence: 99%

“…AA levels showed a strong inverted U function in response to increased DHA supplementation when neural development was evaluated, i.e., at the highest DHA containing formula (0.96%) (DHA:AA ratio 1.5:1.0); it was observed that AA decreased in the blood, as compared to the two low and intermediate formulas (0.32% and 0.64% DHA) [ 92 ]. Today is a standard procedure the fortification of infant formulas with DHA and EPA, which are added as triglycerides, phospholipids, or fatty acid concentrates [ 76 ].…”

Section: Dha and Aa In Brain Developmentmentioning

confidence: 99%

See 1 more Smart Citation

Docosahexaenoic and Arachidonic Acids as Neuroprotective Nutrients throughout the Life Cycle

et al. 2021

View full text Add to dashboard Cite

The role of docosahexaenoic acid (DHA) and arachidonic acid (AA) in neurogenesis and brain development throughout the life cycle is fundamental. DHA and AA are long-chain polyunsaturated fatty acids (LCPUFA) vital for many human physiological processes, such as signaling pathways, gene expression, structure and function of membranes, among others. DHA and AA are deposited into the lipids of cell membranes that form the gray matter representing approximately 25% of the total content of brain fatty acids. Both fatty acids have effects on neuronal growth and differentiation through the modulation of the physical properties of neuronal membranes, signal transduction associated with G proteins, and gene expression. DHA and AA have a relevant role in neuroprotection against neurodegenerative pathologies such as Alzheimer’s disease and Parkinson’s disease, which are associated with characteristic pathological expressions as mitochondrial dysfunction, neuroinflammation, and oxidative stress. The present review analyzes the neuroprotective role of DHA and AA in the extreme stages of life, emphasizing the importance of these LCPUFA during the first year of life and in the developing/prevention of neurodegenerative diseases associated with aging.

show abstract

Section: Dha and Aa During Pregnancy And Breast Milk Periodmentioning

confidence: 99%

Section: Dha and Aa In Brain Developmentmentioning

confidence: 99%

Docosahexaenoic and Arachidonic Acids as Neuroprotective Nutrients throughout the Life Cycle

et al. 2021

View full text Add to dashboard Cite

show abstract

“…For this reason, choline has been recognized as an essential nutrient, because a supplementary intake by foods is necessary. Modern diet does not seem to provide a sufficient intake of choline (RDA: 550 and 425 mg/day for men and women, respectively) [87,88]. In analogy with other methyl donors, also choline deficiency results in HHcy and epigenetic dysregulation of genes controlled through methylation.…”

Section: Cholinementioning

confidence: 99%

Vitamin B Supplementation and Nutritional Intake of Methyl Donors in Patients with Chronic Kidney Disease: A Critical Review of the Impact on Epigenetic Machinery

Cappuccilli

Bergamini²,

Giacomelli³

et al. 2020

Nutrients

View full text Add to dashboard Cite

Cardiovascular morbidity and mortality are several-fold higher in patients with advanced chronic kidney disease (CKD) and end-stage renal disease (ESRD) than in the general population. Hyperhomocysteinemia has undoubtedly a central role in such a prominent cardiovascular burden. The levels of homocysteine are regulated by methyl donors (folate, methionine, choline, betaine), and cofactors (vitamin B6, vitamin B12,). Uremia-induced hyperhomocysteinemia has as its main targets DNA methyltransferases, and this leads to an altered epigenetic control of genes regulated through methylation. In renal patients, the epigenetic landscape is strictly correlated with the uremic phenotype and dependent on dietary intake of micronutrients, inflammation, gut microbiome, inflammatory status, oxidative stress, and lifestyle habits. All these factors are key contributors in methylome maintenance and in the modulation of gene transcription through DNA hypo- or hypermethylation in CKD. This is an overview of the epigenetic changes related to DNA methylation in patients with advanced CKD and ESRD. We explored the currently available data on the molecular dysregulations resulting from altered gene expression in uremia. Special attention was paid to the efficacy of B-vitamins supplementation and dietary intake of methyl donors on homocysteine lowering and cardiovascular protection.

show abstract

“…Infants received enough choline and LC-PUFAs from breast milk, which are very important for the brain, retinal and neurovisional development. In another study, it was emphasized that formula foods containing choline and LC-PUFAs were required for growth and development in non-breastfed infants [64].…”

Section: Breastfeeding and Retinal Diseasementioning

confidence: 99%

Relationship between Ocular Morbidity and Infant Nutrition

Bozkurt¹,

Bozkurt²

2020

Infant Feeding - Breast Versus Formula

View full text Add to dashboard Cite

The nutrition of the constantly growing and developing infant even after birth has an undeniable contribution to the development of eyes, which can be considered as the extension of the brain. Therefore, the elucidation of these physiological developments is valuable in terms of preventing pathological conditions. During the first six months of an infant’s life, nutrition is provided through breast milk or infant formula, and after the sixth month, there is a transition to additional food. Breast milk is, thus, considered as ‘miracle food’, with a growing body of research being undertaken to investigate its relationship with orbital diseases and reporting that breast milk reduces ocular morbidity. Breast milk is an accessible, economical and important nutrition source for eye development and infant health. The developments in recent years have resulted in the content of formula being closer to that of breast milk, which can positively affect the neurovisional development of babies that cannot be fed with breast milk.

show abstract

Choline and DHA in Maternal and Infant Nutrition: Synergistic Implications in Brain and Eye Health

Cited by 59 publications

References 134 publications

Docosahexaenoic and Arachidonic Acids as Neuroprotective Nutrients throughout the Life Cycle

Docosahexaenoic and Arachidonic Acids as Neuroprotective Nutrients throughout the Life Cycle

Vitamin B Supplementation and Nutritional Intake of Methyl Donors in Patients with Chronic Kidney Disease: A Critical Review of the Impact on Epigenetic Machinery

Relationship between Ocular Morbidity and Infant Nutrition

Contact Info

Product

Resources

About