Choline-containing phospholipids and treatment of adult-onset dementia disorders

Amenta, Francesco; Battineni, Gopi; Traini, Enea; Pallotta, Graziano

doi:10.1016/b978-0-12-815854-8.00030-6

Cited by 4 publications

(10 citation statements)

References 31 publications

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“…Other choline-containing PLs include sphingomyelin (SM) which is abundant in the myelin sheath and maintains the integrity of the axonal covering [ 35 ]. SM is also reported to take part in cellular processes, signal transduction and the inflammatory cascade [ 36 ].…”

Section: Importance Of Choline-containing Phospholipids In Brainmentioning

confidence: 99%

“…A study conducted on rats fed with lecithin derived from soybeans or eggs found that forms of lecithin increased brain choline, blood choline and Ach synthesis in the brain [ 122 ]. Lecithin, alone and in combination, has been tested for the potential to regress the progression of dementia and AD in 21 studies and 12 randomized trials [ 35 ]. Clear evidence supporting its role in the amelioration of dementia and AD is not established.…”

Section: Choline-specific Therapeutic Strategies For the Amelioration Of Tbi And Coexisting Neurological Diseasesmentioning

confidence: 99%

“…After administration, it is converted into the metabolic active form of choline, phosphorylcholine. Phosphoryl choline reaches the cholinergic nerve terminals and stimulates Ach synthesis [ 35 ]. α-GPC has shown improved cognitive health by increasing the hippocampal Ach levels; its efficacy in ameliorating dementia and AD is proved [ 133 ].…”

Section: Choline-specific Therapeutic Strategies For the Amelioration Of Tbi And Coexisting Neurological Diseasesmentioning

confidence: 99%

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Dynamics of Choline-Containing Phospholipids in Traumatic Brain Injury and Associated Comorbidities

Javaid

Farooq

Rehman

et al. 2021

IJMS

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The incidences of traumatic brain injuries (TBIs) are increasing globally because of expanding population and increased dependencies on motorized vehicles and machines. This has resulted in increased socio-economic burden on the healthcare system, as TBIs are often associated with mental and physical morbidities with lifelong dependencies, and have severely limited therapeutic options. There is an emerging need to identify the molecular mechanisms orchestrating these injuries to life-long neurodegenerative disease and a therapeutic strategy to counter them. This review highlights the dynamics and role of choline-containing phospholipids during TBIs and how they can be used to evaluate the severity of injuries and later targeted to mitigate neuro-degradation, based on clinical and preclinical studies. Choline-based phospholipids are involved in maintaining the structural integrity of the neuronal/glial cell membranes and are simultaneously the essential component of various biochemical pathways, such as cholinergic neuronal transmission in the brain. Choline or its metabolite levels increase during acute and chronic phases of TBI because of excitotoxicity, ischemia and oxidative stress; this can serve as useful biomarker to predict the severity and prognosis of TBIs. Moreover, the effect of choline-replenishing agents as a post-TBI management strategy has been reviewed in clinical and preclinical studies. Overall, this review determines the theranostic potential of choline phospholipids and provides new insights in the management of TBI.

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Section: Importance Of Choline-containing Phospholipids In Brainmentioning

confidence: 99%

Section: Choline-specific Therapeutic Strategies For the Amelioration Of Tbi And Coexisting Neurological Diseasesmentioning

confidence: 99%

Section: Choline-specific Therapeutic Strategies For the Amelioration Of Tbi And Coexisting Neurological Diseasesmentioning

confidence: 99%

See 1 more Smart Citation

Dynamics of Choline-Containing Phospholipids in Traumatic Brain Injury and Associated Comorbidities

Javaid

Farooq

Rehman

et al. 2021

IJMS

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“…The precursors are first used as a substrate for acetylcholine synthesis, which can improve cholinergic neurotransmission (Hurtado et al, 2011). ACh precursors have been shown to prolong the favorable effects of acetylcholinesterase inhibitors on cognitive and behavioral improvements in patients with Alzheimer's disease (AD) and mild to moderate vascular dementia Amenta et al, 2020). They may have significant neuroprotective benefits in addition to serving as precursors by maintaining and supplying the membrane structure of neurons (Rao et al, 2000).…”

mentioning

confidence: 99%

“…CCPLs and the acetylcholinesterase inhibitors were the treatments more largely studied in clinical trials for the AD consistent with the hypothesis that a replacement/enhancement of the cholinergic function may be useful in the treatment of AD patients. Based on the available results, it has been hypothesized that CCPLs could still have a place in the pharmacotherapy of adult-onset dementia disorders (Amenta et al, 2020).…”

mentioning

confidence: 99%

Effects of choline containing phospholipids on the neurovascular unit: A review

Roy

Tomassoni

Nittari

et al. 2022

Front. Cell. Neurosci.

Self Cite

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The roles of choline and of choline-containing phospholipids (CCPLs) on the maintenance and progress of neurovascular unit (NVU) integrity are analyzed. NVU is composed of neurons, glial and vascular cells ensuring the correct homeostasis of the blood-brain barrier (BBB) and indirectly the function of the central nervous system. The CCPLs phosphatidylcholine (lecithin), cytidine 5′-diphosphocholine (CDP-choline), choline alphoscerate or α-glyceryl-phosphorylcholine (α-GPC) contribute to the modulation of the physiology of the NVU cells. A loss of CCPLs contributes to the development of neurodegenerative diseases such as Alzheimer’s disease, multiple sclerosis, Parkinson’s disease. Our study has characterized the cellular components of the NVU and has reviewed the effect of lecithin, of CDP-choline and α-GPC documented in preclinical studies and in limited clinical trials on these compounds. The interesting results obtained with some CCPLs, in particular with α-GPC, probably would justify reconsideration of the most promising molecules in larger attentively controlled studies. This can also contribute to better define the role of the NVU in the pathophysiology of brain disorders characterized by vascular impairment.

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A comprehensive review on pleiotropic effects and therapeutic potential of soy lecithin

Mangrulkar,

Kulkarni,

Nanepag

et al. 2024

ADV TRADIT MED (ADTM)

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Choline-containing phospholipids and treatment of adult-onset dementia disorders

Cited by 4 publications

References 31 publications

Dynamics of Choline-Containing Phospholipids in Traumatic Brain Injury and Associated Comorbidities

Dynamics of Choline-Containing Phospholipids in Traumatic Brain Injury and Associated Comorbidities

Effects of choline containing phospholipids on the neurovascular unit: A review

A comprehensive review on pleiotropic effects and therapeutic potential of soy lecithin

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