2021
DOI: 10.1155/2021/8817581
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Chromatin Regulation in Development: Current Understanding and Approaches

Abstract: The regulation of mammalian stem cell fate during differentiation is complex and can be delineated across many levels. At the chromatin level, the replacement of histone variants by chromatin-modifying proteins, enrichment of specific active and repressive histone modifications, long-range gene interactions, and topological changes all play crucial roles in the determination of cell fate. These processes control regulatory elements of critical transcriptional factors, thereby establishing the networks unique t… Show more

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Cited by 5 publications
(5 citation statements)
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“…Over the past two decades, remarkable progresses have been made in the characterization of histone modifications in both mouse and human PSCs. 14 , 16 , 61 , 62 , 63 , 64 H3K4me3, catalyzed by TrxG complex, was mapped to the stemness and fundamental gene promoters in PSCs. 14 , 15 However, less has been known regarding how H3K4me3 is recognized in PSCs.…”
Section: Discussionmentioning
confidence: 99%
“…Over the past two decades, remarkable progresses have been made in the characterization of histone modifications in both mouse and human PSCs. 14 , 16 , 61 , 62 , 63 , 64 H3K4me3, catalyzed by TrxG complex, was mapped to the stemness and fundamental gene promoters in PSCs. 14 , 15 However, less has been known regarding how H3K4me3 is recognized in PSCs.…”
Section: Discussionmentioning
confidence: 99%
“…1 ). The optimal genome-wide histone modification technology uses chromatin immunoprecipitation procedures [ 29 ]. ncRNA molecules can act as epigenetic factors [ 30 , 31 ].…”
Section: Molecular Epigenetic Mechanismsmentioning
confidence: 99%
“…The best example is the compacted chromatin structure of heterochromatin that represses gene expression and that is promoted by hypermethylation of DNA versus the less compacted euchromatin that is associated with active gene expression and hypomethylation of DNA [ 24 ]. The optimal genome-wide technology for chromatin structure analysis also uses chromatin immunoprecipitation procedures [ 29 ].…”
Section: Molecular Epigenetic Mechanismsmentioning
confidence: 99%
“…Epigenetic modifications, such as DNA methylation and histone modifications, affect the chromatin structure, altering its accessibility to transcription factors (TFs) and other gene regulators ( 19 , 20 ). EZH2 is a component of the polycomb repressive complex 2 responsible for the trimethylation of H3K27.…”
Section: Introductionmentioning
confidence: 99%