Chromatin regulation in drug addiction and depression

Renthal, William; Nestler, Eric J.

doi:10.31887/dcns.2009.11.3/wrenthal

Cited by 68 publications

(9 citation statements)

References 50 publications

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“…Based on the results of past studies on PD, MAPK can play some roles in degeneration of dopaminergic neurons. The MAPK pathway is thus induced by cocaine that phosphorylates serine 10 of histone H3 via MSK1 (Renthal & Nestler, 2009). In addition, DNA methylation triggers aurora-B kinase and phosphorylates serine 10 of histone H3 (Latham & Dent, 2007).…”

Section: Micrornasmentioning

confidence: 99%

Involvement of aberrant regulation of epigenetic mechanisms in the pathogenesis of Parkinson's disease and epigenetic‐based therapies

Renani

Taheri

Rostami

et al. 2019

Journal Cellular Physiology

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Parkinson's disease (PD) is known as a progressive neurodegenerative disorder associated with the reduction of dopamine-secreting neurons and the formation of Lewy bodies in the substantia nigra and basal ganglia routes. Aging, as well as environmental and genetic factors, are considered as disease risk factors that can make PD as a complex one. Epigenetics means studying heritable changes in gene expression or function, without altering the underlying DNA sequence. Multiple studies have shown the association of epigenetic variations with onset or progression of various types of diseases. DNA methylation, posttranslational modifications of histones and presence of microRNA (miRNA) are among epigenetic processes involved in regulating pathways related to the development of PD. Unlike genetic mutations, most epigenetic variations may be reversible or preventable. Therefore, the return of aberrant epigenetic events in different cells is a growing therapeutic approach to treatment or prevention. Currently, there are several methods for treating PD patients, the most important of which are drug therapies. However, detection of genes and epigenetic mechanisms involved in the disease can develop appropriate diagnosis and treatment of the disease before the onset of disabilities and resulting complications. The main purpose of this study was to review the most important epigenetic molecular mechanisms, epigenetic variations in PD, and epigenetic-based therapies.

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Section: Micrornasmentioning

confidence: 99%

Involvement of aberrant regulation of epigenetic mechanisms in the pathogenesis of Parkinson's disease and epigenetic‐based therapies

Renani

Taheri

Rostami

et al. 2019

Journal Cellular Physiology

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“…The DEA statement restated an often disputed allegation made by the agency in order to classify the chemicals as Schedule I that kratom has no between drug-treated groups and controls, or drug addiction and withdrawal periods, or different stages of treatment, investigators will be able to identify potential biomarkers that could later aid in clinical diagnosis or treatment [33]. The number and type of genes/proteins expressed in specific brain areas can alter due to frequent drug exposure [34,35]. This shift in expression governs the functioning of individual neurons as well as the brain circuits that link them, and it may be responsible for the behavioral abnormalities associated with addiction [36].…”

Section: Introductionmentioning

confidence: 99%

Application of Proteomics in Diagnosis of Kratom Addiction

Khudhair¹,

Murtadha²,

Harn³

2022

Current Trends Anal Bioanal Chem

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Kratom (Mitragyna speciosa) is a medicinal plant grown wildly in Southeast Asian. It has been used traditionally for its analgesic and relaxing effects after hard day of labors. The main alkaloid of kratom, mitragynine binds to opioid receptors to give opioid-like effects, therefore it has been widely utilized as opiate substitute. Long term usage of kratom lead to addiction and has been associated with death. Although rural folks of Southeast Asia are still consumed kratom for its beneficial values. Currently, abused of kratom is identified by the presence of mitragynine in the user's urine. Nevertheless, since kratom are still in used for its stimulating effect, the presence of mitragynine in urine cannot differentiate between chronic user for its opiate-like effect with occasional user for its medicinal effect. In view of the rise of addiction cases to kratom, a method able to detect kratom addiction is greatly needed. Given that drug addiction is a dynamic behavioral and physiological process, the current advancement of proteomic techniques will be able to use for analyzing the expression and alteration of proteins upon addiction to kratom, which concurrently will provide a more thorough knowledge of addiction pathophysiology.

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“…A schematic diagram Figure 2 , represents the epigenetic mechanisms of alcohol and cannabinoid activity and possible hypothetical overlaps between the two at the epigenetic level. Thus, drugs which can target these master regulators can serve as potential therapeutic targets to treat AUDs and other substance abuse [ 122 , 123 ].…”

Section: Introductionmentioning

confidence: 99%

Epigenetic Interactions between Alcohol and Cannabinergic Effects: Focus on Histone Modification and DNA Methylation

Parira

Laverde

Agudelo

2017

J Alcohol Drug Depend

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Epigenetic studies have led to a more profound understanding of the mechanisms involved in chronic conditions. In the case of alcohol addiction, according to the National Institute on Alcohol Abuse and Alcoholism, 16 million adults suffer from Alcohol Use Disorders (AUDs). Even though therapeutic interventions like behavioral therapy and medications to prevent relapse are currently available, no robust cure exists, which stems from the lack of understanding the mechanisms of action of alcohol and the lack of development of precision medicine approaches to treat AUDs. Another common group of addictive substance, cannabinoids, have been studied extensively to reveal they work through cannabinoid receptors. Therapeutic applications have been found for the cannabinoids and a deeper understanding of the endocannabinoid system has been gained over the years. Recent reports of cannabinergic mechanisms in AUDs has opened an exciting realm of research that seeks to elucidate the molecular mechanisms of alcohol-induced end organ diseases and hopefully provide insight into new therapeutic strategies for the treatment of AUDs. To date, several epigenetic mechanisms have been associated with alcohol and cannabinoids independently. Therefore, the scope of this review is to compile the most recent literature regarding alcohol and cannabinoids in terms of a possible epigenetic connection between the endocannabinoid system and alcohol effects. First, we will provide an overview of epigenetics, followed by an overview of alcohol and epigenetic mechanisms with an emphasis on histone modifications and DNA methylations. Then, we will provide an overview of cannabinoids and epigenetic mechanisms. Lastly, we will discuss evidence of interactions between alcohol and cannabinergic pathways and possible insights into the novel epigenetic mechanisms underlying alcohol-cannabinergic pathway activity. Finalizing the review will be a discussion of future directions and therapeutic applications.

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Chromatin regulation in drug addiction and depression

Cited by 68 publications

References 50 publications

Involvement of aberrant regulation of epigenetic mechanisms in the pathogenesis of Parkinson's disease and epigenetic‐based therapies

Involvement of aberrant regulation of epigenetic mechanisms in the pathogenesis of Parkinson's disease and epigenetic‐based therapies

Application of Proteomics in Diagnosis of Kratom Addiction

Epigenetic Interactions between Alcohol and Cannabinergic Effects: Focus on Histone Modification and DNA Methylation

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